Roxatidine acetate hydrochloride
- CAS No.
- 93793-83-0
- Chemical Name:
- Roxatidine acetate hydrochloride
- Synonyms
- RXTA;Altat;Roxit;Xarcin;Neo H2;tzu0460;tzu-0460;PIFEATIDINE;Roxatidine acetate h;ROXATIDINE ACETATE HCL
- CBNumber:
- CB2179214
- Molecular Formula:
- C19H29ClN2O4
- Molecular Weight:
- 384.89756
- MDL Number:
- MFCD00941429
- MOL File:
- 93793-83-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 145-146° |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO: 78 mg/ml; Ethanol: 12 mg/ml; Water: 77 mg/ml |
| form | powder to crystal |
| color | White to Almost white |
| Merck | 14,8274 |
| InChI | InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H |
| InChIKey | FEWCTJHCXOHWNL-UHFFFAOYSA-N |
| SMILES | [H]Cl.C(OCC(=O)NCCCOC1=CC=CC(CN2CCCCC2)=C1)(=O)C |
| FDA UNII | 60426GOR1E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| RTECS | AC3855000 | |||||||||
| HS Code | 2933.39.9200 | |||||||||
| NFPA 704 |
|
Roxatidine acetate hydrochloride price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | R0178 | Roxatidine Acetate Hydrochloride >98.0%(HPLC)(T) | 93793-83-0 | 200mg | $25 | 2026-04-30 | Buy |
| TCI Chemical | R0178 | Roxatidine Acetate Hydrochloride >98.0%(HPLC)(T) | 93793-83-0 | 1g | $88 | 2026-04-30 | Buy |
| Cayman Chemical | 21248 | Roxatidine Acetate (hydrochloride) ≥98% | 93793-83-0 | 250mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 21248 | Roxatidine Acetate (hydrochloride) ≥98% | 93793-83-0 | 500mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 21248 | Roxatidine Acetate (hydrochloride) ≥98% | 93793-83-0 | 1g | $103 | 2026-04-30 | Buy |
Roxatidine acetate hydrochloride Chemical Properties, Uses, Production
Description
Roxatidine acetate hydrochloride is an H2 antagonist, differing considerably in structure from other marketed agents(cimetidine, ranitidine and famotidine) in this category. It is useful in the treatment of gastric, duodenal and anastomotic ulcers, Zollinger-Ellison syndrome and peptic esophagitis.
Description
Roxatidine acetate is a competitive histamine H2 receptor antagonist that upon oral absorption is rapidly converted to its active metabolite roxatidine. By inhibiting the binding of histamine to H2 receptors, roxatidine reduces both intracellular cAMP concentrations and gastric acid secretion by parietal cells.
Chemical Properties
White Solid
Originator
Teikoku Hormone (Japan)
Uses
antibacterial
Uses
A histamine H2-receptor antagonist. It is used to inhibit gastric acid secretion; an antiulcer agent.
Definition
ChEBI: Roxatidine acetate hydrochloride is a member of piperidines. It contains a Roxane.
brand name
ALTAT
Synthesis
108-24-7
78273-80-0
93793-83-0
1. 58 g (0.930 mol, 90% purity) of potassium hydroxide was dissolved in 1160 g of water and cooled to 20-25 °C. Subsequently 300 g (0.854 mol) of roxartan oxalate (compound 9, prepared in Example 7) was added and mixed with stirring. 2. Ethyl acetate (600 g + 450 g) was added to the reaction system, the organic phases were separated, combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give 251 g of Roxaidine (compound 8). 3. 251g of Roxaidine was dissolved in 500g of glacial acetic acid and 170g of acetic anhydride was added. Heat and reflux for 2 h. After confirming that the reaction is complete, concentrate under reduced pressure to remove the acetic acid and cool to 15-20 °C. 4. 600 g of water was added followed by 600 g of ethyl acetate. The pH was adjusted to 9-10 with an aqueous solution containing 300 g of potassium carbonate under stirring. extracted with ethyl acetate (400 g + 300 g), the organic phases were combined, dried with anhydrous sodium sulfate, and the filtrate was concentrated by filtration to give 280 g of ropibutyl acetate (Compound 10). 5. 280 g (0.804 mol) of ropivo butyl acetate was dissolved in 1400 g of acetone and cooled to 0-5 °C. The solution was added dropwise to a mixture containing 32 g of hydrogen chloride. A solution of ethyl acetate containing 32 g of hydrogen chloride was added dropwise and a solid was precipitated. Crystallized at 0-5 °C for 35 h, filtered and dried to give 295 g of rozatidine acetate hydrochloride (theoretical yield: 328.58 g, calculated based on 300 g of compound 9; yield: 89.8%).
References
[1] Patent: CN107698538, 2018, A. Location in patent: Paragraph 0074-0077
Roxatidine acetate hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Chenxin Pharmaceutical Co., Ltd. | 17362916295 | w17362916295@163.com | China | 2995 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4183 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6739 | 52 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
View Latest Price from Roxatidine acetate hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-20 | Roxatidine acetate hydrochloride
93793-83-0
|
1g | 99% | 10kgs/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-15 | Roxatidine Acetate hydrochloride
93793-83-0
|
$29.00 | 99.61% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Roxatidine Acetate hydrochloride
93793-83-0
|
$29.00 | 99.61% | 10g | TargetMol Chemicals Inc. |
-
- Roxatidine acetate hydrochloride
93793-83-0
- $0.00
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Roxatidine Acetate hydrochloride
93793-83-0
- $29.00
- 99.61%
- TargetMol Chemicals Inc.
-
- Roxatidine Acetate hydrochloride
93793-83-0
- $29.00
- 99.61%
- TargetMol Chemicals Inc.
