2-Mercaptobenzoxazole
- CAS No.
- 2382-96-9
- Chemical Name:
- 2-Mercaptobenzoxazole
- Synonyms
- Mercaptobenzoxazole;BENZO[D]OXAZOLE-2-THIOL;benzo[d]oxazole-2(3H)-thione;2-BENZOXAZOLETHIOL;1,3-BENZOXAZOLE-2-THIOL;2QJBBWZ;benzoxazole-2-thiol;2-benzoxazolethione;2-benzoxazolylthiol;Benzoxazolinethione
- CBNumber:
- CB2188290
- Molecular Formula:
- C7H5NOS
- Molecular Weight:
- 151.19
- MDL Number:
- MFCD00005769
- MOL File:
- 2382-96-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Mercaptobenzoxazole 95% | M3507 | 10g | $36.6 |
| 2-Mercaptobenzoxazole >98.0%(GC)(T) | B0096 | 25g | $84 |
| 2-Mercaptobenzoxazole >98.0%(GC)(T) | B0096 | 500g | $694 |
| 2-Mercaptobenzoxazole Asreported | 281524 | 25g | $333 |
| 2-Mercaptobenzoxazole Asreported | 281524 | 50g | $468 |
| More product size | |||
| Melting point | 192-195 °C(lit.) |
|---|---|
| Boiling point | 360°C (rough estimate) |
| Density | 1.2170 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 11.03±0.20(Predicted) |
| form | Crystalline Powder |
| color | Beige |
| PH | 5 (5g/l, H2O, 20℃) |
| Water Solubility | SLIGHTLY SOLUBLE |
| BRN | 119483 |
| InChI | 1S/C7H5NOS/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H,(H,8,10) |
| InChIKey | FLFWJIBUZQARMD-UHFFFAOYSA-N |
| SMILES | Sc1nc2ccccc2o1 |
| CAS DataBase Reference | 2382-96-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 7PFU48RAFX |
| NIST Chemistry Reference | 2(3H)-Benzoxazolethione(2382-96-9) |
| EPA Substance Registry System | 2-Mercaptobenzoxazole (2382-96-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-25-24-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DM4882500 | |||||||||
| F | 13 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Toxicity | mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04482, | |||||||||
| NFPA 704 |
|
2-Mercaptobenzoxazole price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M3507 | 2-Mercaptobenzoxazole 95% | 2382-96-9 | 10g | $36.6 | 2026-04-30 | Buy |
| TCI Chemical | B0096 | 2-Mercaptobenzoxazole >98.0%(GC)(T) | 2382-96-9 | 25g | $84 | 2026-04-30 | Buy |
| TCI Chemical | B0096 | 2-Mercaptobenzoxazole >98.0%(GC)(T) | 2382-96-9 | 500g | $694 | 2026-04-30 | Buy |
| Usbiological | 281524 | 2-Mercaptobenzoxazole Asreported | 2382-96-9 | 25g | $333 | 2026-06-03 | Buy |
| Usbiological | 281524 | 2-Mercaptobenzoxazole Asreported | 2382-96-9 | 50g | $468 | 2026-06-03 | Buy |
2-Mercaptobenzoxazole Chemical Properties,Uses,Production
Chemical Properties
beige crystalline powder
Uses
2-Mercaptobenzoxazole is used in the surface treatment of materials. It is utilized for protection of metals from corrosion.
Preparation
2-Mercaptobenzoxazole has already been described in 1876 by Dunner (Ber. 9, (1876) page 465). 2-Mercaptobenzoxazole and its derivatives are prepared by processes which are based in principle on the reaction between o-aminophenol and alkali metal alkylxanthates. The alkali metal alkylxanthate here can either be employed as such, or it can be produced in the reaction mixture itself from an alkali, a lower alkanol and carbon disulphide.
https://patents.google.com/patent/US4677209A/en
Application
2-Mercaptobenzoxazole is a widely used organic scaffold in medicinal chemistry.
2-Mercaptobenzoxazole and their derivatives are known to posses several biological activities such as antibacterial, antifungal, antiinflammatory, insecticidal and herbicidal. 4-0xo-thiazolidines have also played an important activities as analgesic, anti-HIV, antitubercular, anthelmentic, dye-stuffs, fluorescent and as a photosensitizer. The incorporation of 4-oxothiazolidine and their 5-arylidene moieties in 2-mercaptobenzoxazole frame work has been found to enhance the activity.
Definition
ChEBI: 2-mercapto-1,3-benzoxazole is a benzoxazole.
Reactions
2-Mercaptobenzoxazole with ethyl chloroacetate and anhydrous K2C03 in the presence of dry acetone was refluxed on water bath to give ethyl-2-(mercaptobenzoxazolo)acetate.
Synthesis
75-15-0
95-55-6
2382-96-9
1. 15 mL of ethanol, 3 mL of water, 10 mmol of o-aminophenol, 10 mmol of carbon disulfide, and 10 mmol of potassium hydroxide were sequentially added to the reaction flask. 2. The reaction mixture was heated to 80 °C and stirred at reflux for 3 hours at this temperature. 3. Upon completion of the reaction, a small amount of zeolite was added to the mixture and filtered while hot. 4. Warm the filtrate to 70 °C and slowly pour it into a beaker containing 10 mL of warm water (preheated to 60-70 °C). 5. cool the beaker in an ice-water bath to induce precipitation of the product. 6. The precipitated white transparent needle-like crystals were collected by filtration and dried to give 1.23 g of 2-mercaptobenzoxazole in 81% yield.
References
[1] Patent: CN108794421, 2018, A. Location in patent: Paragraph 0024; 0025; 0027
[2] Heteroatom Chemistry, 2001, vol. 12, # 3, p. 151 - 155
[3] Letters in Organic Chemistry, 2010, vol. 7, # 7, p. 519 - 527
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5374 - 5379
[5] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 913 - 923
2-Mercaptobenzoxazole Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8898 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14035 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2984 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3961 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
View Lastest Price from 2-Mercaptobenzoxazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-29 | 2-Mercaptobenzoxazole
2382-96-9
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-28 | 2-Mercaptobenzoxazole
2382-96-9
|
$119.00 | 1kg | 0.98 | 100kg | Shanghai UCHEM Inc. | |
 |
2026-06-30 | 2-Mercaptobenzoxazole
2382-96-9
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Mercaptobenzoxazole
2382-96-9
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Mercaptobenzoxazole
2382-96-9
- $119.00
- 0.98
- Shanghai UCHEM Inc.
-
- 2-Mercaptobenzoxazole
2382-96-9
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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