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N-(Trimethylsilyl)acetamide

N-(Trimethylsilyl)acetamide Structure
N-(Trimethylsilyl)acetamide structure
CAS No.
13435-12-6
Chemical Name:
N-(Trimethylsilyl)acetamide
Synonyms
trimethylsilyl;N-TRIMETHYLSILYLACETAMIDE;TMSA;CMH3;DK063;CMD1Y;LVNC9;C15orf13;HEL-S-265;HTM-alpha
CBNumber:
CB7667530
Molecular Formula:
C5H13NOSi
Molecular Weight:
131.25
MDL Number:
MFCD00008671
MOL File:
13435-12-6.mol
MSDS File:
SDS
Last updated:2026-05-28 05:55:17
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N-(Trimethylsilyl)acetamide Properties

Melting point 46-49 °C(lit.)
Boiling point 84 °C18 mm Hg(lit.)
Density 0.859±0.06 g/cm3(Predicted)
Flash point 135 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform, DMSO, Methanol
pka 18.23±0.46(Predicted)
form Crystalline Mass
color White to yellow
Water Solubility reacts
Sensitive Moisture Sensitive
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
BRN 741928
Stability Moisture Sensitive
InChI 1S/C5H13NOSi/c1-5(7)6-8(2,3)4/h1-4H3,(H,6,7)
InChIKey LWFWUJCJKPUZLV-UHFFFAOYSA-N
SMILES CC(=O)N[Si](C)(C)C
CAS DataBase Reference 13435-12-6(CAS DataBase Reference)
EWG's Food Scores 1
EPA Substance Registry System Acetamide, N-(trimethylsilyl)- (13435-12-6)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P302+P352-P305+P351+P338
PPE Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  Xi-F,Xi,F
Risk Statements  36/37/38-11
Safety Statements  37/39-26
RIDADR  1325
WGK Germany  3
RTECS  AD0250000
F  10-21
TSCA  TSCA listed
HazardClass  4.1
PackingGroup  III
HS Code  29319090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
NFPA 704
2
1 0

N-(Trimethylsilyl)acetamide price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 223298 N-(Trimethylsilyl)acetamide 95% 13435-12-6 25g $136 2026-04-30 Buy
TCI Chemical T0590 N-Trimethylsilylacetamide >98.0%(GC) 13435-12-6 25g $501 2026-04-30 Buy
Usbiological 291761 N-Trimethylsilylacetamide Asreported 13435-12-6 25g $302 2026-06-03 Buy
Usbiological 291761 N-Trimethylsilylacetamide Asreported 13435-12-6 50g $410 2026-06-03 Buy
Usbiological 291761 N-Trimethylsilylacetamide Asreported 13435-12-6 100g $546 2026-06-03 Buy
Product number Packaging Price Buy
223298 25g $136 Buy
T0590 25g $501 Buy
291761 25g $302 Buy
291761 50g $410 Buy
291761 100g $546 Buy

N-(Trimethylsilyl)acetamide Chemical Properties, Uses, Production

Chemical Properties

WHITE TO YELLOWISH CRYSTALLINE MASS

Uses

N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).

General Description

The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.

Purification Methods

Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

N-(Trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

Cefdinir 2-Methyl-1-(trimethylsiloxy)-1-propene 1-(Trimethylsiloxy)cyclopentene Allylisopropylacetamide

N-(Trimethylsilyl)acetamide Suppliers

Global Suppliers ( 203)
Supplier Tel Email Country ProdList Advantage
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 info@qiaochem.com China 6065 65
Bengbu Chen Yixin Materials Technology Co., Ltd. 15655950695 15655950695 1608252589@qq.com China 498 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Shanghai Qiao Chemical Science Co., Ltd 65
Bengbu Chen Yixin Materials Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Jia Xing Isenchem Co.,Ltd 66
Adamas Reagent, Ltd. 59

View Latest Price from N-(Trimethylsilyl)acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Trimethylsilylacetamide pictures 2026-09-24 N-Trimethylsilylacetamide
13435-12-6
 1kg 97% 20t Hubei Changfu Chemical Co., Ltd.
N-(Trimethylsilyl)acetamide pictures 2026-08-25 N-(Trimethylsilyl)acetamide
13435-12-6
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
N-(Trimethylsilyl)acetamide pictures 2026-06-30 N-(Trimethylsilyl)acetamide
13435-12-6
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

N-(Trimethylsilyl)acetamide Spectrum

N-(Trimethylsilyl)acetamide(13435-12-6)1HNMRN-(Trimethylsilyl)acetamide(13435-12-6)IR1N-(Trimethylsilyl)acetamide(13435-12-6)IR2N-(Trimethylsilyl)acetamide(13435-12-6)Raman

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N-(TRIMETHYLSILYL)ACETAMIDE FOR SYNTHESI N-(Trimethylsilyl)acetamide,97% N-(Trimethylsilyl) (acetylamino)trimethylsilane n-(trimethylsilyl)-acetamid TRIMETHYLSILYLACETAMIDE TMSA TMS ACETAMIDE N-TrimethylsilylacetamideA.R. N-TRIMETHYLSILYL ACETAMIDE(TMSA) N-TMS-acetamide Acetamide, N-(trimethylsilyl)- N-Trimethylsilylacetamide > 13435-12-6 N-(Trimethylsilyl)acetamide DK063 N-(Trimethylsilyl)acetamide C15orf13 CMD1Y CMH3 HEL-S-265 HTM-alpha LVNC9 N-TRIMETHYLSILYLACETAMIDE trimethylsilyl 13435-12-6 C5H13NOSi CH3CONHSiCH33 Derivatization Reagents Fluka Reagents Organic Building Blocks Si (Classes of Silicon Compounds) Silylation (GC Derivatizing Reagents) Silylacetamides Acyclic Alkenes Analytical Chromatography Product Catalog Building Blocks Trimethylsilylation (GC Derivatizing Reagents) Si-N Compounds GC Derivatizing Reagents Silicon Compounds (for Synthesis) Aliphatics Miscellaneous Reagents Analytical Chemistry GC Derivatizing Reagents Si (Classes of Silicon Compounds) Silicon Compounds (for Synthesis) Silylacetamides Silylation (GC Derivatizing Reagents) Si-N Compounds Synthetic Organic Chemistry Trimethylsilylation (GC Derivatizing Reagents)