ChemicalBook >> CAS DataBase List >>N-(Trimethylsilyl)acetamide
N-(Trimethylsilyl)acetamide
- CAS No.
- 13435-12-6
- Chemical Name:
- N-(Trimethylsilyl)acetamide
- Synonyms
- TMSA;CMH3;DK063;CMD1Y;LVNC9;C15orf13;HEL-S-265;HTM-alpha;TMS ACETAMIDE;trimethylsilyl
- CBNumber:
- CB7667530
- Molecular Formula:
- C5H13NOSi
- Molecular Weight:
- 131.25
- MDL Number:
- MFCD00008671
- MOL File:
- 13435-12-6.mol
- MSDS File:
- SDS
Last updated:2026-01-13 11:25:41
| Product description | Number | Pack Size | Price |
| N-(Trimethylsilyl)acetamide 95% | 223298 | 25g | $136 |
| N-Trimethylsilylacetamide >98.0%(GC) | T0590 | 25g | $501 |
| N-Trimethylsilylacetamide | T796720 | 25g | $60 |
| Trimethylsilyl | 468234 | 10g | $319 |
| N-Trimethylsilylacetamide | 42527 | 50g | $640 |
| More product size | |||
| Melting point | 46-49 °C(lit.) |
|---|---|
| Boiling point | 84 °C18 mm Hg(lit.) |
| Density | 0.859±0.06 g/cm3(Predicted) |
| Flash point | 135 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform, DMSO, Methanol |
| pka | 18.23±0.46(Predicted) |
| form | Crystalline Mass |
| color | White to yellow |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 741928 |
| Stability | Moisture Sensitive |
| InChI | 1S/C5H13NOSi/c1-5(7)6-8(2,3)4/h1-4H3,(H,6,7) |
| InChIKey | LWFWUJCJKPUZLV-UHFFFAOYSA-N |
| SMILES | CC(=O)N[Si](C)(C)C |
| CAS DataBase Reference | 13435-12-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| EPA Substance Registry System | Acetamide, N-(trimethylsilyl)- (13435-12-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi-F,Xi,F | |||||||||
| Risk Statements | 36/37/38-11 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| RIDADR | 1325 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AD0250000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
N-(Trimethylsilyl)acetamide price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 223298 | N-(Trimethylsilyl)acetamide 95% | 13435-12-6 | 25g | $136 | 2026-03-19 | Buy |
| TCI Chemical | T0590 | N-Trimethylsilylacetamide >98.0%(GC) | 13435-12-6 | 25g | $501 | 2026-03-19 | Buy |
| TRC | T796720 | N-Trimethylsilylacetamide | 13435-12-6 | 25g | $60 | 2021-12-16 | Buy |
| Usbiological | 468234 | Trimethylsilyl | 13435-12-6 | 10g | $319 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 42527 | N-Trimethylsilylacetamide | 13435-12-6 | 50g | $640 | 2021-12-16 | Buy |
N-(Trimethylsilyl)acetamide Chemical Properties,Uses,Production
Chemical Properties
WHITE TO YELLOWISH CRYSTALLINE MASS
Uses
N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).
General Description
The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.
Purification Methods
Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]
N-(Trimethylsilyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 203)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Changfu Chemical Co., Ltd. | +86-02784396550 +86-17721064038 | sales@cfsilanes.com | China | 479 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Hubei Co-Formula Material Tech Co., Ltd. | +86-27-84459282 | sales@cfmats.com | CHINA | 882 | 58 |
View Lastest Price from N-(Trimethylsilyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | N-Trimethylsilylacetamide
13435-12-6
|
US $0.00 / kg | 1kg | 97% | 20t | Hubei Changfu Chemical Co., Ltd. | |
 |
2026-04-17 | N-(Trimethylsilyl)acetamide
13435-12-6
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-12-01 | N-(Trimethylsilyl)acetamide
13435-12-6
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- N-Trimethylsilylacetamide
13435-12-6
- US $0.00 / kg
- 97%
- Hubei Changfu Chemical Co., Ltd.
-
- N-(Trimethylsilyl)acetamide
13435-12-6
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- N-(Trimethylsilyl)acetamide
13435-12-6
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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N-(TRIMETHYLSILYL)ACETAMIDE FOR SYNTHESI
N-(Trimethylsilyl)acetamide,97%
N-(Trimethylsilyl)
(acetylamino)trimethylsilane
n-(trimethylsilyl)-acetamid
N-TRIMETHYLSILYLACETAMIDE
TRIMETHYLSILYLACETAMIDE
TMSA
TMS ACETAMIDE
N-TrimethylsilylacetamideA.R.
trimethylsilyl
N-TRIMETHYLSILYL ACETAMIDE(TMSA)
N-TMS-acetamide
Acetamide, N-(trimethylsilyl)-
N-Trimethylsilylacetamide >
13435-12-6 N-(Trimethylsilyl)acetamide
DK063
N-(Trimethylsilyl)acetamide
C15orf13
CMD1Y
CMH3
HEL-S-265
HTM-alpha
LVNC9
13435-12-6
C5H13NOSi
CH3CONHSiCH33
Derivatization Reagents
Fluka Reagents
Organic Building Blocks
Si (Classes of Silicon Compounds)
Silylation (GC Derivatizing Reagents)
Silylacetamides
Acyclic
Alkenes
Analytical Chromatography Product Catalog
Building Blocks
Trimethylsilylation (GC Derivatizing Reagents)
Si-N Compounds
GC Derivatizing Reagents
Silicon Compounds (for Synthesis)
Aliphatics
Miscellaneous Reagents
Analytical Chemistry
GC Derivatizing Reagents
Si (Classes of Silicon Compounds)
Silicon Compounds (for Synthesis)
Silylacetamides
Silylation (GC Derivatizing Reagents)
Si-N Compounds
Synthetic Organic Chemistry
Trimethylsilylation (GC Derivatizing Reagents)
