Chloromethyl phenyl sulfone
- CAS No.
- 7205-98-3
- Chemical Name:
- Chloromethyl phenyl sulfone
- Synonyms
- Ai3-09778;Einecs 230-581-8;CHLOROMETHYL PHENYL;PHENYL CHLOROMETHYL SULFONE;2-ChloroMethylphenylsulfone;Chloromethyl phenyl sulfone;chloromethyl phenyl sulphone;Phenylsulfonylmethyl chloride;(Phenylsulfonyl)chloromethane;1-(Chloromethylsulfonyl)benzene
- CBNumber:
- CB2210252
- Molecular Formula:
- C7H7ClO2S
- Molecular Weight:
- 190.65
- MDL Number:
- MFCD00007551
- MOL File:
- 7205-98-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 51-53 °C (lit.) |
|---|---|
| Boiling point | 130 °C / 1mmHg |
| Density | 1.336±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 2046644 |
| InChI | 1S/C7H7ClO2S/c8-6-11(9,10)7-4-2-1-3-5-7/h1-5H,6H2 |
| InChIKey | NXAIQSVCXQZNRY-UHFFFAOYSA-N |
| SMILES | ClCS(=O)(=O)c1ccccc1 |
| CAS DataBase Reference | 7205-98-3(CAS DataBase Reference) |
| FDA UNII | QB5SR7NM49 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 21 | |||||||||
| HS Code | 29049095 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
Chloromethyl phenyl sulfone price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 324604 | Chloromethyl phenyl sulfone ≥97% | 7205-98-3 | 5g | $61.1 | 2023-06-20 | Buy |
| TCI Chemical | C1571 | Chloromethyl Phenyl Sulfone >98.0%(GC) | 7205-98-3 | 5g | $122 | 2026-04-30 | Buy |
| TCI Chemical | C1571 | Chloromethyl Phenyl Sulfone >98.0%(GC) | 7205-98-3 | 25g | $400 | 2026-04-30 | Buy |
| Apolloscientific | OR322095 | 1-(Chloromethylsulfonyl)benzene >98% | 7205-98-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR322095 | 1-(Chloromethylsulfonyl)benzene >98% | 7205-98-3 | 5g | $52 | 2026-06-04 | Buy |
Chloromethyl phenyl sulfone Chemical Properties, Uses, Production
Uses
Chloromethyl Phenyl Sulfone is used to synthesis of α,β-epoxy sulfones and aziridines; reacts with electrophilic arenes, heterocyclic arenes, and alkenes; source of the α-phenylsulfonylmethyl radical.
Preparation
Preparative Methods of Chloromethyl Phenyl Sulfone: several methods are available. The most convenient is the reaction of Sodium Benzenesulfinate dihydrate with bromochloromethane in dimethyl sulfoxide.
Synthesis
100-68-5
3112-85-4
7205-98-3
The general procedure for the synthesis of phenylmethyl sulfone and chloromethyl phenyl sulfone from methyl phenyl sulfide was as follows: 0.25 g (2 mmol) of methyl phenyl sulfide was used as a substrate and added to a 50 mL three-necked flask along with 10 mL of acetonitrile and 2 mL of water. The internal temperature of the flask was maintained at 23 °C. Subsequently, 0.09 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals were added in portions with continuous stirring. During the reaction, the internal temperature of the flask was increased to 28°C and then gradually decreased. GC analysis was performed 3 h after the start of the reaction and showed that 22% of the methyl phenyl sulfide was converted to methyl phenyl sulfoxide and 65% to methyl phenyl sulfone. By-products included 6% chloromethyl phenyl sulfoxide and 7% chloromethyl phenyl sulfone, and a total of 0.8% advanced chlorides. Addition of 0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was continued and stirring was continued for 1 hour. At this point, the methyl phenyl sulfide and methyl phenyl sulfoxide completely disappeared and the yield of methyl phenyl sulfone increased to 87%. Impurities included 11% chloromethyl phenyl sulfone, 0.5% dichloromethyl phenyl sulfone and 1.3% trichloromethyl phenyl sulfone.
Solubility in organics
Chloromethyl Phenyl Sulfone is soluble in THF, CHCl3, CH2Cl2, and most organic solvents.
References
[1] Patent: JP2017/52730, 2017, A. Location in patent: Paragraph 0046
Chloromethyl phenyl sulfone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
View Latest Price from Chloromethyl phenyl sulfone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | CHLOROMETHYL PHENYL SULFONE
7205-98-3
|
$6.60 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- CHLOROMETHYL PHENYL SULFONE
7205-98-3
- $6.60
- 97%-99%
- Career Henan Chemical Co
