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D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE

D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE structure

CAS No.: 91224-37-2

Chemical Name:: D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE

Synonyms: SPANTIDE;SPANTIDE I;(D-Arg1,D-Trp7;SPANTIDE HYDROCHLORIDE;M.W. 1497.80 C75H108N20O13;1-Arg-7,9-Trp-11-Leu-substance p;(D-ARG1,D-TRP7,9,LEU11)-SUBSTANCE P;(D-Arg?,D-Trp?·?,Leu??)-Substance P;[D-Arg1,D-Trp7,9,L-Leu11]substance P;Substance p, Arg(1)-Trp(7,9)-Leu(11)-

CBNumber:: CB2230566

Molecular Formula:: C75H108N20O13

Molecular Weight:: 1497.79

MDL Number:: MFCD00076805

MOL File:: 91224-37-2.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:51

Product description	Number	Pack Size	Price
SpantideI	1784	1	$161
Spantide I	S5370	1mg	$389
(D-Arg1,D-Trp7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2	FA108555	5mg	$420
SPANTIDE I 95.00%	PEP0003817	1MG	$591.82
(D-Arg1,D-Trp7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2	FA108555	10mg	$730

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D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE Properties

Density	1.43±0.1 g/cm3(Predicted)
storage temp.	−20°C
pka	13.31±0.20(Predicted)
form	Powder
color	White to off-white
Water Solubility	Soluble to 1 mg/ml in water

SAFETY

Risk and Safety Statements

WGK Germany	3

D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	1784	SpantideI	91224-37-2	1	$161	2021-12-16	Buy
Usbiological	S5370	Spantide I	91224-37-2	1mg	$389	2021-12-16	Buy
Biosynth Carbosynth	FA108555	(D-Arg1,D-Trp7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2	91224-37-2	5mg	$420	2021-12-16	Buy
American Custom Chemicals Corporation	PEP0003817	SPANTIDE I 95.00%	91224-37-2	1MG	$591.82	2021-12-16	Buy
Biosynth Carbosynth	FA108555	(D-Arg1,D-Trp7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2	91224-37-2	10mg	$730	2021-12-16	Buy

Product number	Packaging	Price	Buy
1784	1	$161	Buy
S5370	1mg	$389	Buy
FA108555	5mg	$420	Buy
PEP0003817	1MG	$591.82	Buy
FA108555	10mg	$730	Buy

D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation[1][2][3].

in vivo

Spantide I (50 and 100 nM perfused through the cerebral ventricles) causes a complete respiratory arrest in all of the examined animals^[2].
Spantide I (36 μg/mouse, ip daily) significantly decreases the number of perforated corneas, bacterial counts, and PMNs. Spantide I also downregulates the mRNA levels for type I cytokines (e.g., IFN-γ) as well as MIP-2, IL-6, TNF-α, and IL-1β^[3].

Animal Model:	Female, 8-week-old C57BL/6 (B6) and BALB/c mice^[3].
Dosage:	36 μg/mouse.
Administration:	IP on days -1 and 0 (day of infection) and daily through 5 days pi (post infection).
Result:	At 3 and 5 days pi, compound-treated mice had significantly less severe ocular disease than did the PBS-treated mice. Contained significantly fewer PMNs than the corneas of PBS-treated mice at 3 and 5 days pi. Significantly reduced levels of corneal TNF-α mRNA at 3 and 5 days pi. Significantly reduced the level of IL-18 mRNA at 1 day pi.

IC 50

NK1: 230 nM (Ki); NK2: 8150 nM (Ki)

References

[1] J C Beaujouan, et al. Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br J Pharmacol. 1993 Mar;108(3):793-800. DOI:10.1111/j.1476-5381.1993.tb12880.x
[2] M Zubrzycka, et al. Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr Regul. 2000 Mar;34(1):13-8. PMID:10808247
[3] Linda D Hazlett, et al. Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):797-807. DOI:10.1167/iovs.06-0882

D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE Suppliers

Global( 84)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150	support@tgpeptide.com	China	3279	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5218	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hangzhou Go Top Peptide Biotech	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58
Aladdin Scientific	58
Changsha MOL Changes Biotechnology Co., Ltd.	58

91224-37-2(D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE)Related Search:

Bithionol 2'-Deoxyadenosine Octamethylcyclotetrasiloxane D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 3HCL 8H2O

GALANIN (1-13)-SPANTIDE I

1of2

[D-ARG1,D-TRP7,9,LEU11]-SUBSTANCE P HYDROCHLORIDE (D-ARG1,D-TRP7,9,LEU11)-SUBSTANCE P D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE H-D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 (D-arg1,D-trp7,9,leu11)-substance P*acetate D-ARG1,D-TRP7,9,LEU11]-SUBSTANCE P (SPANTIDE) M.W. 1497.80 C75H108N20O13 [D-Arg1,D-Trp7,9,L-Leu11]substance P D-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2 D-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2 1-Arg-7,9-Trp-11-Leu-substance p L-Leucinamide, D-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl- Substance p, 1-D-arginine-7-D-tryptophan-9-D-tryptophan-11-D-leucine- Substance p, Arg(1)-Trp(7,9)-Leu(11)- Substance p, arginyl(1)-tryptophyl(7,9)-leucine(11)- (D-Arg1,D-Trp7 (D-Arg1,D-Trp7·9,Leu11)-Substance P, Spantide I SUBSTANCE P, [D-ARG1, D-TRP7,9, LEU11] SPANTIDE HYDROCHLORIDE SPANTIDE I SPANTIDE (D-Arg1,D-Trp7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 (D-Arg?,D-Trp?·?,Leu??)-Substance P 91224-37-2 C75H108N20O13 Antagonist Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Tachykinins Tachykinin receptor