2-Chloro-6-methoxynicotinaldehyde
- CAS No.
- 95652-80-5
- Chemical Name:
- 2-Chloro-6-methoxynicotinaldehyde
- Synonyms
- 2-Chloro-6-methoxynicotinaldehyde;2-CHLORO-6-METHOXYPYRIDINE-3-CARBALDEHYDE;2-chloro-6-methoxy-3-pyridine-carboxaldehyde;3-Pyridinecarboxaldehyde, 2-chloro-6-methoxy-
- CBNumber:
- CB22454427
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD10697549
- MOL File:
- 95652-80-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-Chloro-6-methoxynicotinaldehyde price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VDA65280 | 2-Chloro-6-methoxynicotinaldehyde | 95652-80-5 | 1g | $389.4 | 2026-06-05 | Buy |
| Biosynth | VDA65280 | 2-Chloro-6-methoxynicotinaldehyde | 95652-80-5 | 2g | $649 | 2026-06-05 | Buy |
| Biosynth | VDA65280 | 2-Chloro-6-methoxynicotinaldehyde | 95652-80-5 | 5g | $1168.2 | 2026-06-05 | Buy |
| Matrix Scientific | 306594 | 2-Chloro-6-methoxynicotinaldehyde | 95652-80-5 | 250.00mg | $58 | 2026-05-19 | Buy |
| Matrix Scientific | 306594 | 2-Chloro-6-methoxynicotinaldehyde | 95652-80-5 | 1.00g | $169 | 2026-05-19 | Buy |
2-Chloro-6-methoxynicotinaldehyde Chemical Properties, Uses, Production
Synthesis
17228-64-7
68-12-2
95652-80-5
Over 5 min at -78 °C, 2-chloro-6-methoxypyridine (4.14 mL, 34.8 mmol) was slowly added dropwise to a mixture of tert-butyllithium (1.7 M pentane solution, 22.5 mL, 38.3 mmol) and 69 mL THF. The reaction mixture was stirred continuously at -78 °C for 1 h. Subsequently, N,N-dimethylformamide (3.5 mL, 45.0 mmol) was added and stirring was continued at -78 °C for 1.5 h. The reaction was completed with the addition of N,N-dimethylformamide (3.5 mL, 45.0 mmol). Upon completion of the reaction, the reaction was quenched by the addition of glacial acetic acid (4.0 mL, 69.0 mmol) and slowly warmed to room temperature over 30 minutes. Ether (200 mL) was added to dilute the reaction mixture, and the organic phase was washed sequentially with saturated aqueous sodium bicarbonate (50 mL) and brine (50 mL) and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the crude product obtained was recrystallized from hexane to give 4.6 g (76% yield) of 2-chloro-6-methoxynicotinaldehyde as a light yellow solid, melting point: 67.0-68.0 °C. The product was analyzed by 1H NMR (1H NMR). The product was confirmed by 1H NMR (300 MHz, CDCl3): δ 10.29 (d, J = 0.8 Hz, 1H), 8.05 (d, J = 7.9 Hz, 1H), 7.02 (dd, J1 = 7.9 Hz, J2 = 0.8 Hz, 1H), 4.08 (s, 3H); 13C NMR (75 MHz, CDCl3): δ 188.0, 164.2, 154.6, 140.0, 117.6, 117.5, 54.8; IR (ATR, cm-1): 3103, 2869, 1683, 1567, 1468, 1378, 1273, 1005.
References
[1] Patent: WO2017/118762, 2017, A1. Location in patent: Page/Page column 40; 41
2-Chloro-6-methoxynicotinaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-Chloro-6-methoxynicotinaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Shanghai Aonan chemical technology co.,ltd. | info@aonanchem.com | China | 65 | 55 | |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
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| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
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| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6746 | 58 |
