6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- CAS No.
- 179248-59-0
- Chemical Name:
- 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- Synonyms
- Edr;HHAT;Mar2;HB-1;MART2;SKI-1;MEF3L;Src I1;Src-l1;Src Inhibitor-1
- CBNumber:
- CB22508388
- Molecular Formula:
- C22H19N3O3
- Molecular Weight:
- 373.41
- MDL Number:
- MFCD01815300
- MOL File:
- 179248-59-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 528.151±50.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.267±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| form | white powder |
| pka | 6.753±0.30(predicted) |
| color | White or off-white |
| biological source | rabbit |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| InChI | 1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25) |
| InChIKey | DMWVGXGXHPOEPT-UHFFFAOYSA-N |
| SMILES | COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H413 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P405-P501a-P280-P301+P312+P330-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
6,7-Dimethoxy-N-(4-phenoxyphenyl)- price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S2075 | Src Inhibitor-1 ≥98% (HPLC) | 179248-59-0 | 5mg | $201 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB1303011 | ANTI-HHAT (N-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 400μL | $496 | 2025-07-31 | Buy | |
| Sigma-Aldrich | SAB5300036 | Monoclonal Anti-PEG10 antibody produced in mouse clone 4C10A7, ascites fluid | 179248-59-0 | 100μL | $503 | 2023-01-07 | Buy |
| Sigma-Aldrich | SAB5300035 | Monoclonal Anti-PEG10 antibody produced in mouse clone 1B1C4, ascites fluid | 179248-59-0 | 100μL | $503 | 2023-01-07 | Buy |
| Cayman Chemical | 14592 | Src Kinase Inhibitor I ≥98% | 179248-59-0 | 1mg | $36 | 2026-04-30 | Buy |
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Chemical Properties,Uses,Production
Description
Src-I1 (179248-59-0) is a potent and competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50‘s = 44 nM for Src and 88 nM for Lck). Src-I1 also inhibits VEGFR2 (IC50 = 320 nM).
Uses
Src Kinase inhibitor 1 lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy
Uses
Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.
Definition
ChEBI: Src Inhibitor-1 is a member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of quinazolines, a secondary amino compound, an aromatic ether and a polyether.
General Description
A potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 μM, respectively).
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
[1] GAOCHAO TIAN. Structural Determinants for Potent, Selective Dual Site Inhibition of Human pp60c-src by 4-Anilinoquinazolines[J]. Biochemistry Biochemistry, 2001, 40 24: 7084-7091. DOI:10.1021/bi0100586
[2] JENNY BAIN. The selectivity of protein kinase inhibitors: a further update.[J]. Biochemical Journal, 2007: 297-315. DOI:10.1042/bj20070797
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
View Lastest Price from 6,7-Dimethoxy-N-(4-phenoxyphenyl)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Src Inhibitor 1
179248-59-0
|
$34.00-91.00 | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-26 | 46,7-Dimethoxy-N-(4-phenoxyphenyl)-
179248-59-0
|
$1.00 | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- Src Inhibitor 1
179248-59-0
- $34.00-91.00
- 99.68%
- TargetMol Chemicals Inc.
-
- 46,7-Dimethoxy-N-(4-phenoxyphenyl)-
179248-59-0
- $1.00
- 97%-99.9%
- Career Henan Chemical Co
