N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide
- CAS No.
- 96605-66-2
- Chemical Name:
- N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide
- Synonyms
- Zaleplon Impurity 2;N-Ethyl-N-3-((3-dime;Zaleplon Impurity 12;Zaleplon related coMpound A;2-propenyl]phenyl]-N-ethyl-;N-Ethyl-N-3-[(3-Dimethylamine-;Zaleplon Related CoMpound A CIV;Zaleplon USP Related Compound A;Acetamide, N-[3-[3-(dimethylamino)-1-oxo-;N-Ethyl-N-3-[(3-diMethylaMine-1-oxo-2-propene)phen
- CBNumber:
- CB2256685
- Molecular Formula:
- C15H20N2O2
- Molecular Weight:
- 260.33
- MDL Number:
- MFCD04117958
- MOL File:
- 96605-66-2.mol
- MSDS File:
- SDS
| Melting point | 111.0 to 115.0 °C |
|---|---|
| Boiling point | 400.7±45.0 °C(Predicted) |
| Density | 1.087±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane |
| form | powder to crystal |
| pka | 6.40±0.70(Predicted) |
| color | Light orange to Yellow to Green |
| Major Application | pharmaceutical (small molecule) |
| CAS DataBase Reference | 96605-66-2(CAS DataBase Reference) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H314-H227 |
| Precautionary statements | P501-P260-P270-P262-P210-P271-P264-P280-P284-P370+P378-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405 |
| WGK Germany | WGK 3 |
| HS Code | 29242990 |
| Storage Class | 11 - Combustible Solids |
| REACH Registrations | Active |
N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1724361 | Zaleplon Related Compound A United States Pharmacopeia (USP) Reference Standard | 15mg | $1390 | 2026-04-30 | Buy | |
| TCI Chemical | D4259 | N-[3-[3-(Dimethylamino)acryloyl]phenyl]-N-ethylacetamide >98.0%(GC)(T) | 96605-66-2 | 1g | $23 | 2026-04-30 | Buy |
| TCI Chemical | D4259 | N-[3-[3-(Dimethylamino)acryloyl]phenyl]-N-ethylacetamide >98.0%(GC)(T) | 96605-66-2 | 5g | $38 | 2026-04-30 | Buy |
| Biosynth | FD70834 | N-[3-(3-Dimethylamino-1-oxo-2-propenyl)phenyl]-N-ethylacetamide | 96605-66-2 | 50g | $150 | 2026-06-04 | Buy |
| Biosynth | FD70834 | N-[3-(3-Dimethylamino-1-oxo-2-propenyl)phenyl]-N-ethylacetamide | 96605-66-2 | 25g | $150 | 2026-06-04 | Buy |
N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide Chemical Properties, Uses, Production
Uses
An impurity and intermediate of Zaleplon production.It is used as a reagent in the preparation of immunogens for immunodetection and quantification of pyrazolopyrimidine sedatives.
Synthesis
4637-24-5
200630-96-2
96605-66-2
1. Acetamidoacetophenone (0.2 g, 1.13 mmol) was dissolved in acetone (2 mL), potassium hydroxide (63 mg, 1.13 mmol) was added, followed by ethyl iodide (0.45 mL, 5.64 mmol). After stirring at room temperature overnight, the reaction mixture was concentrated to dryness. The residue was redissolved in ethyl acetate, washed sequentially with water and brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give N-(3-acetylphenyl)-N-ethylacetamide as an orange powder (0.23 g, 100%) with a melting point of 203-204 °C. 2. The above product (0.23 g, 1.13 mmol) was dissolved in acetonitrile (2 mL), N,N-dimethylformamide dimethyl acetal (150 μL, 0.12 mmol) was added, and the reaction was carried out in a microwave reactor at 180 °C for 10 min. After evaporation of the solvent, the residue was filtered and washed with ethyl acetate/petroleum ether (1:3) to afford N-[3-(3-dimethylaminopropenoyl)phenyl]-N-ethylacetamide as an orange solid (0.30 g, 100%). 3. The above substance (0.228 g, 0.88 mmol), 4-hydroxyphenylguanidine nitrate (0.188 g, 0.88 mmol) and sodium hydroxide (35 mg, 0.88 mmol) were mixed in acetonitrile (2 mL), and heated in a microwave reactor for 15 min at 190 °C. After evaporation of the solvent, the residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether, 1:1) to afford N-ethyl-N-3-[(3-dimethylamino-1-oxo-2-propenyl)phenyl]-acetamide as a yellow solid (117 mg, 38%).
References
[1] Patent: WO2005/12262, 2005, A1. Location in patent: Page/Page column 45-46
[2] Patent: CN105622615, 2016, A. Location in patent: Paragraph 0128; 0129; 0130; 0131
N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide
96605-66-2
|
$8.00 | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide
96605-66-2
- $8.00
- 98%
- Career Henan Chemical Co
