Hexafluoroacetone trihydrate
- CAS No.
- 34202-69-2
- Chemical Name:
- Hexafluoroacetone trihydrate
- Synonyms
- HEXAFLUOROACETONE HYDRATE;gc7787;HFA·3H2O;Hexafluoroacet;uoroacetone trihydrate;Protirelin Impurity 12;Perfluoroacetone hydrate;PERFLUOROACETONE TRIHYDRATE;hexafluoro-acetontrihydrate;Hexafluoracetone trihydrate
- CBNumber:
- CB2264341
- Molecular Formula:
- C3H6F6O4
- Molecular Weight:
- 220.07
- MDL Number:
- MFCD00149061
- MOL File:
- 34202-69-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 18-21 °C(lit.) |
|---|---|
| Boiling point | 106-108 °C |
| Density | 1.579 g/mL at 25 °C(lit.) |
| vapor pressure | 87.5 psi ( 21 °C) |
| refractive index |
n |
| Flash point | 105-106°C |
| storage temp. | Store at room temperature |
| Water Solubility | Completely soluble in water |
| form | liquid |
| Specific Gravity | 1.579 |
| color | colorless |
| Merck | 14,4685 |
| BRN | 607236 |
| InChI | InChI=1S/C3F6O.3H2O/c4-2(5,6)1(10)3(7,8)9;;;/h;3*1H2 |
| InChIKey | SNZAEUWCEHDROX-UHFFFAOYSA-N |
| SMILES | C(F)(F)(F)C(=O)C(F)(F)F.O.O.O |
| CAS DataBase Reference | 34202-69-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H331-H310-H314-H361 | |||||||||
| Precautionary statements | P202-P261-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25-34-63 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2552 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UC2700000 | |||||||||
| Hazard Note | Highly Toxic | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2914790090 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Eye Dam. 1 Repr. 2 Skin Corr. 1B |
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| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Hexafluoroacetone trihydrate price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 139238 | Hexafluoroacetone trihydrate 98% | 34202-69-2 | 5g | $29.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 139238 | Hexafluoroacetone trihydrate 98% | 34202-69-2 | 25g | $112 | 2026-04-30 | Buy |
| TCI Chemical | H0425 | Hexafluoroacetone Hydrate >97.0%(T) | 34202-69-2 | 5g | $23 | 2025-07-31 | Buy |
| TCI Chemical | H0425 | Hexafluoroacetone Hydrate >97.0%(T) | 34202-69-2 | 25g | $47 | 2025-07-31 | Buy |
| Strem Chemicals | 09-4571 | Hexafluoroacetone trihydrate, min. 97% min.97% | 34202-69-2 | 5g | $46 | 2026-04-30 | Buy |
Hexafluoroacetone trihydrate Chemical Properties, Uses, Production
Description
Hexafluoroacetone trihydrate, also known as gem diol, hexafluoropropan-2,2- diol, is a covalent hydrate of the ketone. It could used as a structure stabilizer for peptides. It was a metabolite of aerosol propellant HFA-227 and is present in the urine. It was shown to undergo an efficient carbonyl-ene reaction with a variety of alkenes in the presence of molecular sieves under microwave heating and conventional heating producing hexafluoroisopropanol functionalized derivatives in high yields[1-2].
Uses
Hexafluoroacetone trihydrate was used to study the kinetics and thermodynamics of linkage isomerization of (acetone)pentaammineruthenium (III) and-ruthenium (II) complexes. It was used in a study to reconstitute the α-and β-polypeptides of both Rhodobacter sphaeroides and Rhodospirillum rubrum with bacteriochlorophyll a.
Uses
Hexafluoroacetone trihydrate (HFA3H2O) is used to produce Sevoflurane,a high quality anesthetic and Bisphenol AF, a crosslinker for fluoroelastomers. It can also be used to produce various high-end fluorinated products such as fluorinated polyimide, etc.
General Description
Hexafluoroacetone trihydrate forms crystalline 1:1 complexes with imidazole 3-oxides.
Synthesis
A spherical fluorinated alumina catalyst (30 g) (particle diameter: 2 to 4 mm) was charged into a reaction tube made of SUS316 (inner diameter: 16 mm, length: 460 mm). The reaction tube was heated to 140° C, and hexafluoro-1,2-epoxypropane (purity: 95%, impurity content: 5% hexafluoropropene) was fed into the reaction tube under the conditions of a feed rate of 50 Nml/min and a total pressure of 3 atmospheres. After 1 hour, the exit gas was analyzed by gas chromatography, with the result that the conversion of hexafluoro-1,2-epoxypropane was 100%. The exit gas was passed into the water, producing crude hexafluoroacetone trihydrate.
References
[1] Sridhar M, et al. A facile method for the preparation of hexafluoroisopropanol functionalized derivatives using hexafluoroacetone trihydrate via a carbonyl-ene reaction. Tetrahedron Letters, 2009; 50: 1777-1779.
[2] Kster U, et al. Biotransformation of the aerosol propellant 1,1,1,2,3,3,3-heptafluoropropane (HFA-227): lack of protein binding of the metabolite hexafluoroacetone. Drug Metabolism and Disposition , 1996.
Hexafluoroacetone trihydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Qicheng Chemical Co. , Ltd. | 0531-15628998092 15628998092 | 418597063@QQ.com | China | 245 | 58 |
| West fluorine technology co., ltd | 0531-85906692 15588812394 | 325912682@qq.com | China | 370 | 58 |
| SHANG FLUORO | 021-65170832 15601903708 | qinba_1@163.com | China | 401 | 60 |
| Shandong Dexin Fine Chemical Co., Ltd. | 18553366272 | 3091507995@qq.com | China | 278 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from Hexafluoroacetone trihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Hexafluoroacetone trihydrate
34202-69-2
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | Hexafluoroacetone trihydrate
34202-69-2
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-12-25 | Hexafluoroacetone trihydrate
34202-69-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Hexafluoroacetone trihydrate
34202-69-2
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- Hexafluoroacetone trihydrate
34202-69-2
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Hexafluoroacetone trihydrate
34202-69-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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