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1,1,1-Trifluoroacetone

1,1,1-Trifluoroacetone Structure
1,1,1-Trifluoroacetone structure
CAS No.
421-50-1
Chemical Name:
1,1,1-Trifluoroacetone
Synonyms
TRIFLUOROACETONE;1,1,1-TRIFLUORO-2-PROPANONE;CH3COCF3;1,1,1-trifluoro-propan-2-one;2-Propanone, 1,1,1-trifluoro-;Methyl trifluoromethyl ketone;1,1,1-TrifL;uoroacetone;Trilfuoroacetone;1,1,1-Trifluoroaceto
CBNumber:
CB4123453
Molecular Formula:
C3H3F3O
Molecular Weight:
112.05
MDL Number:
MFCD00000423
MOL File:
421-50-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:47:54
Product description Number Pack Size Price
1,1,1-Trifluoroacetone 97% T62804 5g $39.5
1,1,1-Trifluoroacetone 97% T62804 25g $121
1,1,1-Trifluoroacetone (in cylinder without valve) [To use this product charged in cylinder, a valve is required which is sold separately (Product Code:V0030)] T2921 100G $385
1,1,1-Trifluoroacetone Asreported 290738 2g $336
1,1,1-Trifluoroacetone Asreported 290738 5g $463
More product size
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1,1,1-Trifluoroacetone Properties

Melting point -78 °C
Boiling point 22 °C(lit.)
Density 1.252 g/mL at 25 °C(lit.)
vapor pressure 13.62 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Flash point −23 °F
storage temp. 2-8°C
solubility Chloroform, Methanol
form Liquid
color Clear colorless
Water Solubility Miscible
Sensitive Lachrymatory
BRN 1748614
Henry's Law Constant 1.4×100 mol/(m3Pa) at 25℃, Burkholder et al. (2019)
Stability Volatile
InChI 1S/C3H3F3O/c1-2(7)3(4,5)6/h1H3
InChIKey FHUDAMLDXFJHJE-UHFFFAOYSA-N
SMILES CC(=O)C(F)(F)F
CAS DataBase Reference 421-50-1(CAS DataBase Reference)
FDA UNII K987U5C2CX
NIST Chemistry Reference 2-Propanone, 1,1,1-trifluoro-(421-50-1)
EPA Substance Registry System 2-Propanone, 1,1,1-trifluoro- (421-50-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Corrosion (GHS05)
GHS02,GHS05
Signal word  Danger
Hazard statements  H224-H314-H318-H412
Precautionary statements  P210-P233-P240-P241-P242-P243-P280-P260-P264-P273-P303+P361+P353-P370+P378-P301+P330+P331-P363-P304+P340-P310-P305+P351+P338-P403+P235-P405-P501
PPE Eyeshields, Faceshields, Gloves
Hazard Codes  F+,Xi,F
Risk Statements  12-36/37/38
Safety Statements  16-26-29-33-36-7/9-9-37/39-39
RIDADR  UN 1993 3/PG 1
WGK Germany  3
F  19
Hazard Note  Flammable/Lachrymatory
TSCA  TSCA listed
HazardClass  3
PackingGroup  I
HS Code  29147090
Storage Class 3 - Flammable liquids
Hazard Classifications Aquatic Chronic 3
Eye Dam. 1
Flam. Liq. 1
Skin Corr. 1B
REACH Registrations Active
Limited Quantities 0.5 L (0.1 gallon)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (300g or 300ml)
NFPA 704
4
3 1

1,1,1-Trifluoroacetone price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T62804 1,1,1-Trifluoroacetone 97% 421-50-1 5g $39.5 2026-04-30 Buy
Sigma-Aldrich T62804 1,1,1-Trifluoroacetone 97% 421-50-1 25g $121 2026-04-30 Buy
TCI Chemical T2921 1,1,1-Trifluoroacetone (in cylinder without valve) [To use this product charged in cylinder, a valve is required which is sold separately (Product Code:V0030)] 421-50-1 100G $385 2021-12-16 Buy
Usbiological 290738 1,1,1-Trifluoroacetone Asreported 421-50-1 2g $336 2026-06-03 Buy
Usbiological 290738 1,1,1-Trifluoroacetone Asreported 421-50-1 5g $463 2026-06-03 Buy
Product number Packaging Price Buy
T62804 5g $39.5 Buy
T62804 25g $121 Buy
T2921 100G $385 Buy
290738 2g $336 Buy
290738 5g $463 Buy

1,1,1-Trifluoroacetone Chemical Properties,Uses,Production

Chemical Properties

1,1,1-Trifluoroacetone is CLEAR COLOURLESS LIQUID

Uses

1,1,1-Trifluoroacetone is used as intermediate of bioactive substance and antihypertensive drug, and as effective synthetic building block and trifluoromethyl reaction reagent.

Uses

1,1,1-Trifluoroacetone is a general chemical reagent used in the synthesis of glucokinase-glucokinase regulatory protein) GK-GKRP disruptors which may act as potential targets for type II diabetics. Reactant for enantioselective cycloadditions.

Uses

Used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction.

1,1,1-Trifluoroacetone Preparation Products And Raw materials

Raw materials

Preparation Products

4-Amino-2-(trifluoromethyl)quinoline 2-METHYL-4-TRIFLUOROMETHYL-NICOTINIC ACID 3-Thiophenecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester 2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID trifluoromethylglyoxal-bis(guanylhydrazone)
2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBALDEHYDE Butanoic acid, 4,4,4-trifluoro-2,3-dihydroxy-3-methyl- HEXAFLUOROACETYLACETONE Ethyl 3-hydroxy-3-methyl-4,4,4-trifluorobutyrate 2-Butenoic acid, 4,4,4-trifluoro-3-methyl-, methyl ester
1,1,1-trifluoro-4-morpholin-4-yl-3-(morpholin-4-ylmethyl)butane-2,2-di ol 1,1,1,5,5,6,6,6-OCTAFLUORO-2,4-HEXANEDIONE

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1,1,1-Trifluoroacetone Suppliers

Global( 211)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhengzhou Lingzhiyue Technology Co., Ltd
+86-0371-55074660 +86-13523716970 Lingzhiyue@aliyun.com China 3137 58
Jinan Langhua Chemical Co.,ltd.
+8613220563796 sales@fluoro.com China 222 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 sales1@chuanghaibio.com China 5216 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14034 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1444 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8491 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2949 58
Supplier Advantage
Zhengzhou Lingzhiyue Technology Co., Ltd
58
Jinan Langhua Chemical Co.,ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Fluoropharm Co., Ltd. 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58

View Lastest Price from 1,1,1-Trifluoroacetone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,1,1-Trifluoroacetone pictures 2026-08-14 1,1,1-Trifluoroacetone
421-50-1
 $23.00 1kg 99% 200mt Jinan Finer Chemical Co., Ltd
Trifluoroacetone pictures 2026-05-28 Trifluoroacetone
421-50-1
 $3.60 1KG 99% 5000kg Hebei Chuanghai Biotechnology Co,.LTD
1,1,1-Trifluoroacetone pictures 2026-03-20 1,1,1-Trifluoroacetone
421-50-1
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd

1,1,1-Trifluoroacetone Spectrum

1,1,1-Trifluoroacetone(421-50-1)MS1,1,1-Trifluoroacetone(421-50-1)1HNMR1,1,1-Trifluoroacetone(421-50-1)IR1

421-50-1(1,1,1-Trifluoroacetone)Related Search:

Citric acid monohydrate Acetylacetone Pyruvic acid Trifluoroacetic acid Triacetonamine
1,1,3-Trichloroacetone Calcium pyruvate Thenoyltrifluoroacetone Trifluoroacetophenone 3-BROMO-1,1,1-TRIFLUOROACETONE,1-BROMO-3,3,3-TRIFLUOROACETONE 97%,1-BROMO-3,3,3-TRIFLUOROACETONE,3-Bromo-1,1,1-trifluoroacetone, min. 97%
Propiophenone Phenylacetone METHYL TRIFLUOROPYRUVATE Ethyl trifluoropyruvate PALLADIUM(II) HEXAFLUOROACETYLACETONATE
Ethyl 4,4,4-trifluoroacetoacetate ZIRCONIUM TRIFLUOROACETYLACETONATE 4,4,4-Trifluoro-1-phenyl-1,3-butanedione

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1,1,1-trifluoro-2-propanon 3,3,3-Trifluoroacetone Methyl trifluoromethyl ketone Trifluoromethyl methyl ketone 1,1,1-TRIFLUOROACETONE Trilfuoroacetone TFK,1,1,1-Trifluoroaceto 1,1,1-Trifluoroacetone,95% 1,1,1-Trifluoroacetone, 98+% 1,1,1-Trifluroacetone 2-Propanone, 1,1,1-trifluoro- 1,1,1,-Trifluoroacetone 98% 1,1,1-TRIFLUOROACETONE, 60% IN WATER 1,1,1-Trifluoroacetone (TFK) 1,1,three 1-fluorideacetone 1,1,1-Trifluoroacetone (in cylinder without valve) [To use this product charged in cylinder, a valve is required which is sold separately (Product Code:V0030)] 1,1,1-Trifluoroacetone ,99% 1,1,1-Trifluoroaceto 1,1,1-TRIFLUOROACETONE FOR SYNTHESIS 1,1,1-TrifL uoroacetone Three fluorine acetone 1,1,1-Trifluoroacetone,97% 1,1,1-trifluoro-propan-2-one 1,1,1-TRIFLUORO-2-PROPANONE CH3COCF3 TRIFLUOROACETONE 421-50-1 C3H3OF3 C3H3F3O CF3COCH3 KETONE Organic Building Blocks Ketones C3 to C6 Carbonyl Compounds Building Blocks C3 to C6 Carbonyl Compounds Ketones