N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
![N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Structure](CAS/20180629/GIF/118290-26-9.gif)
- CAS No.
- 118290-26-9
- Chemical Name:
- N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
- Synonyms
- AF-DX-384; AF-DX384;AF-DX 384 Free Base;N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-
- CBNumber:
- CB22751069
- Molecular Formula:
- C27H38N6O2
- Molecular Weight:
- 478.63
- MDL Number:
- MFCD00884624
- MOL File:
- 118290-26-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Properties
| Boiling point | 618.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.144±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble10mg/mL, clear (warmed) |
| form | powder |
| pka | 11.55±0.20(Predicted) |
| color | white to beige |
| InChIKey | MZDYABXXPZNUCT-UHFFFAOYSA-N |
| SMILES | N4(C(CCCC4)CN(CCC)CCC)CCNC(=O)[n]1c2ncccc2[nH][c](c3c1cccc3)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0620 | AF-DX 384 Free Base ≥98% (HPLC) | 118290-26-9 | 5mg | $98.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0620 | AF-DX 384 Free Base ≥98% (HPLC) | 118290-26-9 | 25mg | $365 | 2022-05-15 | Buy |
| Cayman Chemical | 25638 | AF-DX 384 ≥95% | 118290-26-9 | 1mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 25638 | AF-DX 384 ≥95% | 118290-26-9 | 5mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 25638 | AF-DX 384 ≥95% | 118290-26-9 | 10mg | $142 | 2026-04-30 | Buy |
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Chemical Properties, Uses, Production
Description
AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively). It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 μM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg. It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine .
Uses
AF-DX 384 is a potent mAChR M2/mAChR M4selective antagonist.
Definition
ChEBI: N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide is a benzodiazepine.
storage
Store at RT
References
[1] F DRJE. Antagonist binding profiles of five cloned human muscarinic receptor subtypes.[J]. Journal of Pharmacology and Experimental Therapeutics, 1991, 256 2: 727-733.
[2] M.G VANNUCCHI. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats[J]. Neuroscience, 1997, 79 3: Pages 837-846. DOI: 10.1016/s0306-4522(97)00091-2
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Absin Bioscience Inc. | 13761418683 | fengmj@univ-bio.com | China | 12045 | 58 |
View Latest Price from N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-14 | AF-DX 384 free base
118290-26-9
|
$68.00 | 98.01% | 10g | TargetMol Chemicals Inc. |
-
- AF-DX 384 free base
118290-26-9
- $68.00
- 98.01%
- TargetMol Chemicals Inc.
