(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester
- CAS No.
- 130721-78-7
- Chemical Name:
- (4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester
- Synonyms
- tert-Butyl (4-chloropyridin-2-yl)carbamate;2-BOC-AMINO-4-CHLOROPYRIDINE;ert-Butyl(4-chloropyridin-2-yl)carbamate;tert-butyl N-(4-chloro-2-pyridyl)carbamate;tert-butyl N-(4-chloropyridin-2-yl)carbamate;(4-Chloro-Pyridin-2-Yl)-Carbamic Acid Tert-Butyl Este;(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester;Carbamic acid, N-(4-chloro-2-pyridinyl)-, 1,1-dimethylethyl ester;(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH;tert-butyl 4-chloropyridin-2-ylcarbamate,(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester,tert-Butyl (4-chloropyridin-2-yl)carbamate,(4-Chloro-Pyridin-2-YL)-Carbamic Acid Tert-Butyl Ester,2-Boc-amino-4-chloropyridine
- CBNumber:
- CB2278180
- Molecular Formula:
- C10H13ClN2O2
- Molecular Weight:
- 228.68
- MDL Number:
- MFCD05663519
- MOL File:
- 130721-78-7.mol
- MSDS File:
- SDS
| Melting point | (dec) |
|---|---|
| Boiling point | 274℃ |
| Density | 1.245 |
| Flash point | 120℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 11.89±0.70(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H13ClN2O2/c1-10(2,3)15-9(14)13-8-6-7(11)4-5-12-8/h4-6H,1-3H3,(H,12,13,14) |
| InChIKey | ATOQLEMIFREXLS-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1=NC=CC(Cl)=C1 |
(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000275 | (4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester Aldrich | 130721-78-7 | 1g | $761 | 2023-06-20 | Buy |
| AstaTech | CL0027 | 2-BOC-AMINO-4-CHLOROPYRIDINE 97% | 130721-78-7 | 1G | $32 | 2026-04-30 | Buy |
| AstaTech | CL0027 | 2-BOC-AMINO-4-CHLOROPYRIDINE 97% | 130721-78-7 | 5G | $117 | 2026-04-30 | Buy |
| AstaTech | CL0027 | 2-BOC-AMINO-4-CHLOROPYRIDINE 97% | 130721-78-7 | 10G | $175 | 2026-04-30 | Buy |
| Biosynth | FFA72178 | 2-(Boc-amino)-4-chloropyridine | 130721-78-7 | 10g | $354 | 2026-06-04 | Buy |
(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester Chemical Properties, Uses, Production
Uses
tert-Butyl (4-chloropyridin-2-yl)carbamate is used as an organic synthesis intermediate and a pharmaceutical intermediate for laboratory research and development processes and in the synthesis of pharmaceutical chemicals.
Synthesis
19798-80-2
24424-99-5
130721-78-7
LHMDS (1 M tetrahydrofuran solution, 17.11 mL, 17.11 mmol) was dissolved in tetrahydrofuran (5 mL) at -5 °C and tetrahydrofuran solution (5 mL) of 4-chloropyridin-2-amine (1 g, 7.78 mmol) was slowly added and stirred for 5 min. Subsequently, tetrahydrofuran solution (5 mL) of di-tert-butyl dicarbonate (Boc2O, 1.898 mL, 8.18 mmol) was added to the reaction mixture. The reaction system was maintained at 0°C and stirring was continued for 2 h. Upon completion of the reaction, the reaction was quenched by the addition of aqueous ammonium chloride solution. The pH of the reaction solution was adjusted to 6 with 1.5 N hydrochloric acid, followed by extraction with ethyl acetate (3 x 15 mL). The organic phases were combined and washed sequentially with sodium bicarbonate solution (15 mL), water (15 mL) and brine (15 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (gradient elution with ethyl acetate/petroleum ether) to afford the target product tert-butyl (4-chloropyridin-2-yl)carbamate (1.435 g, 6.28 mmol, 81% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 10.10 (s, 1H), 8.23 (d, J = 5.20 Hz, 1H), 7.88 (d, J = 2.00 Hz, 1H), 7.15 (dd, J = 2.00, 5.20 Hz, 1H), 1.48 (s, 9H).
References
[1] Angewandte Chemie - International Edition, 2015, vol. 54, # 20, p. 6037 - 6040
[2] Angew. Chem., 2015, vol. 127, # 20, p. 6135 - 6138,4
[3] Patent: WO2015/116060, 2015, A1. Location in patent: Page/Page column 97
[4] Patent: JP2015/528018, 2015, A. Location in patent: Paragraph 0198
[5] Patent: WO2011/139891, 2011, A1. Location in patent: Page/Page column 54
(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiaxing Yat Tai Biotechnology Co. , Ltd. | 15824386662 | 416719813@qq.com | China | 112 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 659 | 62 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Tianjin Branch Chong pharmaceutical intermediates Co., Ltd. | 022-60116533 13207668525 | saleskc@scipharmacn.com | China | 360 | 58 |
View Latest Price from (4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
130721-78-7
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
130721-78-7
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
130721-78-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
130721-78-7
- $1.00
- 98%
- Career Henan Chemical Co
