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PAROMOMYCIN SULFATE

PAROMOMYCIN SULFATE Structure
PAROMOMYCIN SULFATE structure
CAS No.
1263-89-4
Chemical Name:
PAROMOMYCIN SULFATE
Synonyms
PAROMOMYCIN SULPHATE;sulf;humatin;NEOMYCIN E;PAROMOMYCIN SULFATE SALT;Neomycin Sulfate EP Impurity E;O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate;fi5853;D00868;Humagel
CBNumber:
CB2278832
Molecular Formula:
C23H47N5O18S
Molecular Weight:
713.71
MDL Number:
MFCD00079278
MOL File:
1263-89-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-22 15:57:46
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PAROMOMYCIN SULFATE Properties

Melting point 145 °C (decomp)
alpha D25 +50.5° (c = 1.5 in water pH 6)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.
form powder
color White to Off-White
Water Solubility Soluble in water
Merck 14,7041
BRN 5715182
Stability Hygroscopic
InChIKey LJRDOKAZOAKLDU-UDXJMMFXSA-N
CAS DataBase Reference 1263-89-4
FDA UNII 845NU6GJPS
NCI Drug Dictionary Humatin
EPA Substance Registry System Paromomycin sulfate (1263-89-4)
UNSPSC Code 12352200
NACRES NA.72

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  23/24/25-36/38-39/23/24/25-61-36/37/38
Safety Statements  26-36/37-45-38-36
WGK Germany  2
RTECS  WK2320000
HS Code  2941901010
Storage Class 11 - Combustible Solids
Toxicity LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)

PAROMOMYCIN SULFATE price More Price(83)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P5057 Paromomycin sulfate salt powder, BioReagent, suitable for cell culture, ≥98% 1263-89-4 1g $71 2026-04-30 Buy
Sigma-Aldrich 512731 Paromomycin Sulfate - CAS 1263-89-4 - Calbiochem An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. 1263-89-4 5G $148 2022-05-15 Buy
TCI Chemical P2092 Paromomycin Sulfate >94.0%(HPLC) 1263-89-4 1g $47 2026-04-30 Buy
TCI Chemical P2092 Paromomycin Sulfate >94.0%(HPLC) 1263-89-4 5g $140 2026-04-30 Buy
Cayman Chemical 23634 Paromomycin (sulfate) ≥98% 1263-89-4 5g $69 2026-04-30 Buy
Product number Packaging Price Buy
P5057 1g $71 Buy
512731 5G $148 Buy
P2092 1g $47 Buy
P2092 5g $140 Buy
23634 5g $69 Buy

PAROMOMYCIN SULFATE Chemical Properties, Uses, Production

Description

Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.

Chemical Properties

PAROMOMYCIN SULFATE is White to Off-White Solid

Uses

antibacterial, antiamebic

Uses

polymeric nonionic detergent

Uses

PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.

Definition

ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.

brand name

Humatin (King); Humatin (Parke- Davis).

General Description

Chemical structure: aminoglycoside

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Clinical Use

The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.
Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.

Safety Profile

Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.

Purification Methods

Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]

PAROMOMYCIN SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

PAROMOMYCIN SULFATE Suppliers

Global Suppliers ( 396)
Supplier Tel Email Country ProdList Advantage
Hubei Weideli Chemical Reagent Co.，Ltd. 181-6332-1995 18062128043 18163321995@163.com China 4810 58
Hubei Hongyun long biological technology Co. Ltd. 13554337556 13554337556 342063746@qq.com China 2229 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Supplier Advantage
Hubei Weideli Chemical Reagent Co.，Ltd. 58
Hubei Hongyun long biological technology Co. Ltd. 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Adamas Reagent, Ltd. 59
Chemsky（shanghai）International Co.,Ltd. 50
Sinopharm Chemical Reagent Co,Ltd. 79

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View Latest Price from PAROMOMYCIN SULFATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Paromomycin Sulfate pictures 2026-09-18 Paromomycin Sulfate
1263-89-4
 1KG ≥675μg/mg; USP 500kg WUHAN FORTUNA CHEMICAL CO., LTD
Paromomycin Sulfate pictures 2026-09-18 Paromomycin Sulfate
1263-89-4
 1g More Than 99% 50kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
PAROMOMYCIN SULFATE pictures 2026-08-12 PAROMOMYCIN SULFATE
1263-89-4
 $610.00 1KG 98% 1-10mt Baoji Guokang Healthchem Co., Ltd.

PAROMOMYCIN SULFATE Spectrum

PAROMOMYCIN SULFATE(1263-89-4)1HNMR

1263-89-4 (PAROMOMYCIN SULFATE) Related Search:

Spectinomycin dihydrochloride Nitazoxanide Spiramycin Rimonabant Ribostamycin sulfate
(R)-2-Aminocyclohenanol PAROMOMYCIN SULFATE paromomycin 5-Deoxy-D-ribose C-(Tetrahydro-pyran-2-yl)-methylamine hydrochloride
trans-2-Aminocyclohexanol hydrochloride D-Glucosamine 6-sulfate sodium chloride Methyl beta-D-ribofuranoside 3-Butoxy-propionaldehyde diethyl acetal 3-Amino-cyclohexanol
{PAROMOMYCIN SULFATE--N/H PAROMOMYCIN SULFATE USP(CRM STANDARD) PAROMOMYCIN SULFATE WHO(CRM STANDARD)

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PAROMOMYCIN SULFATE PAROMOMYCIN SULFATE SALT NEOMYCIN E aminosidinesulfate aminosidinesulphate aminosidinsulfate fi5853 gabbroral D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI) D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI) Farmiglucin Farminosidin Humagel Paramicina Pargonyl Paricina Sinosid Paromomycin Sufate D00868 Humatin (tn) Paromomycin sulfate (jan/usp) Paromomycin sulfate ,98% Paromomycin Sulfate (125 mg) PayoMoMycin Sulfate O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate humatin humycinsulfate streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof paromomycin sulfate cell culture tested paromomycin sulfate plant cell*culture tested paromomycin sulphates D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1) Barone sulfate kanamycin Solution, 100ppm PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+% PAROMOMYCIN SULFATE USP 97+% Paramomycinsulfate 1600 Antibiotic Aminosidin sulphate Aminoxidin O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate Paromomycin sulphate solution,1000ppm solution Paromomycin sulphate solution,100ppm Neomycin Sulfate EP Impurity E Paromomycin Sulfate - CAS 1263-89-4 - Calbiochem Framycetin EP Impurity E Paromomycin Sulfate > PAROMOMYCIN SULFATE USP/EP/BP Paromomycin Sulfater Framycetin sulfate EP Impurity E (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate(1:x) Paromomycin Sulfate (PRM) Paromomycin Sulfate (1500003) Paromomycine sulphate Baromycin sulfate Paromomycin Sulfate, ≥ 94.0% Sparsentan Impurity 29 Paromomycin sulfate, aminoglycoside antibiotic