Clomethiazole
- CAS No.
- 533-45-9
- Chemical Name:
- Clomethiazole
- Synonyms
- Distraneurin;CLOMETHIAZOLE;Clomethiazolum;Chlorethiazole;chlormethiazole;Clomethiazole 98%;ChlormethiazoleHCl;CLOMETHIAZOLE HCL;Clomethiazole in methanol;Clomethiazole, 10 mM in DMSO
- CBNumber:
- CB2286790
- Molecular Formula:
- C6H8ClNS
- Molecular Weight:
- 161.65
- MDL Number:
- MFCD00868012
- MOL File:
- 533-45-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 127-128 °C |
|---|---|
| Boiling point | bp7 92° |
| Density | d425 1.233 |
| refractive index | 1.6000 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | pKa 3.2 (Uncertain) |
| form | Oil |
| color | Pale Yellow |
| CAS DataBase Reference | 533-45-9(CAS DataBase Reference) |
| FDA UNII | 0C5DBZ19HV |
| ATC code | N05CM02,N05CX04 |
| NIST Chemistry Reference | Clomethiazole(533-45-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H302-H319-H412 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P273-P501 |
| HS Code | 2934100090 |
Clomethiazole price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 30040 | 5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE 97% | 533-45-9 | 1G | $89 | 2026-04-30 | Buy |
| AstaTech | 30040 | 5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE 97% | 533-45-9 | 5G | $257 | 2026-04-30 | Buy |
| Biosynth | FC16096 | Chlormethiazole | 533-45-9 | 0.025kg | $345.15 | 2026-06-04 | Buy |
| Biosynth | FC16096 | Chlormethiazole | 533-45-9 | 0.05kg | $493.08 | 2026-06-04 | Buy |
| Biosynth | FC16096 | Chlormethiazole | 533-45-9 | 1kg | $1972.31 | 2026-06-04 | Buy |
Clomethiazole Chemical Properties, Uses, Production
Uses
Hypnotic.
Uses
Clomethiazolum is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant.
Definition
ChEBI: 5-(2-chloroethyl)-4-methylthiazole is a member of thiazoles.
brand name
Clomiazin;Distraneurine;Emineurina;Gebriazol;Hemineurine;Heminevrin;Somnevrin.
World Health Organization (WHO)
Clomethiazole, which has sedative, anxiolytic and anticonvulsant activity, was introduced in 1960 for the treatment of acute alcohol withdrawal, delirium tremens, status epilepticus, eclamptic toxaemia, sleep disturbances in the elderly and agitation in psychogeriatic patients. It is also used as a sedative in certain anaesthetic procedures. There is little evidence of primary dependence in man but secondary dependence can occur in patients with a history of abuse of other substances, particularly alcohol. Dependence of this type has been reported as a result of inappropriate, long-term prescribing to outpatient alcoholics. Clomethiazole should not be prescribed to alcoholics who continue to drink. Adverse interactions with alcohol have been fatal. Although not controlled under the 1971 Convention on Psychotropic Substances, clomethiazole is subject to analogous controls in some countries.
Biological Activity
Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
Synthesis
137-00-8
533-45-9
The general procedure for the synthesis of 5-(2-chloroethyl)-4-methylthiazole from 4-methyl-5-hydroxyethylthiazole was as follows: referring to Example 18, 2-(4-methylthiazol-5-yl)ethanol (500 mg, 3.49 mmol) was dissolved in thionyl chloride (4 mL). The reaction mixture was stirred under reflux conditions for 3 hours. After completion of the reaction, the mixture was concentrated to dryness to give a light yellow solid product (680 mg, yield: 98%). The product was analyzed by ESI-MS and showed m/z: 162.0 [M + H]+.
References
[1] Patent: US2017/158680, 2017, A1. Location in patent: Paragraph 0385
[2] Journal of the American Chemical Society, 2001, vol. 123, # 6, p. 1017 - 1022
[3] Pharmaceutical Chemistry Journal, 1999, vol. 33, # 12, p. 658 - 660
[4] Journal of the American Chemical Society, 1982, vol. 104, # 18, p. 4934 - 4943
[5] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5988 - 6003
Clomethiazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-4000505016 13380397412 | 3001272453@qq.com | China | 5000 | 50 |
| Baiyin Chengze Chemical Technology Co., Ltd. | +86 943-8535351 13389336721 | sales@chengzechem.com | China | 300 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3769 | 55 |
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