ChemicalBook >> CAS DataBase List >>5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE structure

CAS No.: 145915-60-2

Chemical Name:: 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Synonyms: DAPH-7;DAPH 2;CGP 53353;CGP-53353 solid;CGP 53353, 10 mM in DMSO;PKC_βII/EGFR Inhibitor;5,6-bis((4-fluorophenyl)amino)isoindoline-1,3-dione;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem;5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE;5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

CBNumber:: CB2299648

Molecular Formula:: C20H13F2N3O2

Molecular Weight:: 365.33

MDL Number:: MFCD00938569

MOL File:: 145915-60-2.mol

Last updated:2026-01-13 11:17:29

Product description	Number	Pack Size	Price
CGP-53353 The PKC	539652	2mg	$272
CGP-53353 solid	C7866	5mg	$313
CGP53353 ≥99%(HPLC)	2442	10	$265
CGP53353	C583575	2.5mg	$325
CGP 53353	254940	10mg	$531

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5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Properties

storage temp.	2-8°C
solubility	DMSO: >10mg/mL
form	solid
color	orange
InChI	1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)
InChIKey	RONQPWQYDRPRGG-UHFFFAOYSA-N
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

WGK Germany	3
Storage Class	11 - Combustible Solids

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	539652	CGP-53353 The PKC	145915-60-2	2mg	$272	2024-03-01	Buy
Sigma-Aldrich	C7866	CGP-53353 solid	145915-60-2	5mg	$313	2022-05-15	Buy
Tocris	2442	CGP53353 ≥99%(HPLC)	145915-60-2	10	$265	2021-12-16	Buy
TRC	C583575	CGP53353	145915-60-2	2.5mg	$325	2021-12-16	Buy
Usbiological	254940	CGP 53353	145915-60-2	10mg	$531	2021-12-16	Buy

Product number	Packaging	Price	Buy
539652	2mg	$272	Buy
C7866	5mg	$313	Buy
2442	10	$265	Buy
C583575	2.5mg	$325	Buy
254940	10mg	$531	Buy

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Chemical Properties,Uses,Production

Uses

CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines.

Definition

ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides.

Biological Activity

Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro .

IC 50

PKCβII: 0.41 mM (IC₅₀); PKCβI: 3.8 mM (IC₅₀)

storage

Store at RT

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Suppliers

Global( 43)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15838	69
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	71826	60
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2970	58
Changzhou Chenhong Biotechnology Co., Ltd.	+86-0519-85788828 +86-13775037613	sales@chemrenpharm.com	China	4023	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
BOC Sciences	65
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Rechem science Co., Ltd.	58
Changzhou Chenhong Biotechnology Co., Ltd.	58

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Spectrum

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE(145915-60-2)¹HNMR

145915-60-2(5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE)Related Search:

4-FLUORODIPHENYLAMINE 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE 4,5-DIANILINOPHTHALIMIDE 3,4-Dimethyldiphenylamine

CGP 53353 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE 5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2 DAPH 2 DAPH-7 PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]- CGP-53353 solid 5,6-bis((4-fluorophenyl)amino)isoindoline-1,3-dione CGP 53353, 10 mM in DMSO PKC_βII/EGFR Inhibitor 145915-60-2 C20H13F2N3O2 BioChemical Cell Signaling and Neuroscience Cell Biology Protein Kinase C (PKC) Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Protein Kinase