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5-Dibenzosuberenone

5-Dibenzosuberenone structure

CAS No.: 2222-33-5

Chemical Name:: 5-Dibenzosuberenone

Synonyms: DIBENZOSUBERENONE;Dibenzo[a,d]cyclohepten-5-one;5H-DIBENZO[A,D]CYCLOHEPTEN-5-ONE;NSC 86151;Dibenzosberenone;5-DIBENZOSUBERENONE;DIBENZOSUBERENONE-5;Dibenzosuberenone>Dibenzosuberenone,97%;2,3,6,7-Dibenzotropone

CBNumber:: CB2706074

Molecular Formula:: C15H10O

Molecular Weight:: 206.24

MDL Number:: MFCD00003588

MOL File:: 2222-33-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:41:27

Product description	Number	Pack Size	Price
5-Dibenzosuberenone 97%	D31737	25g	$204
5-Dibenzosuberenone 97%	D31737	100g	$210
Dibenzosuberenone >98.0%(GC)	D1791	25g	$64
5-Dibenzosuberenone	FD21530	1kg	$900
5-Dibenzosuberenone	FD21530	0.5kg	$900
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5-Dibenzosuberenone Properties

Melting point	87-88 °C (lit.)
Boiling point	210 °C / 3mmHg
Density	1.0701 (rough estimate)
vapor pressure	0.006Pa at 25℃
refractive index	1.6324 (estimate)
Flash point	>110℃
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Crystalline Powder
Specific Gravity	1.156
color	White to pale yellow or beige
Water Solubility	Soluble in chloroform, ethyl acetate. Insoluble in water.
BRN	743171
InChI	1S/C15H10O/c16-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)15/h1-10H
InChIKey	SNVTZAIYUGUKNI-UHFFFAOYSA-N
SMILES	O=C1c2ccccc2C=Cc3ccccc13
LogP	3.508 at 25℃
CAS DataBase Reference	2222-33-5(CAS DataBase Reference)
FDA UNII	XQJHQ6T1YB
NIST Chemistry Reference	5H-Dibenzo[a,d]cyclohepten-5-one(2222-33-5)
EPA Substance Registry System	5H-Dibenzo[a,d]cyclohepten-5-one (2222-33-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS09

Signal word

Warning

Hazard statements

H410

Precautionary statements

P273-P391-P501

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25-36-26

RIDADR

3077

WGK Germany

RTECS

HP1147500

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29143990

Storage Class

11 - Combustible Solids

Toxicity

mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02244,

REACH Registrations

Active

NFPA 704

	1
2		0

5-Dibenzosuberenone price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D31737	5-Dibenzosuberenone 97%	2222-33-5	25g	$204	2026-04-30	Buy
Sigma-Aldrich	D31737	5-Dibenzosuberenone 97%	2222-33-5	100g	$210	2026-04-30	Buy
TCI Chemical	D1791	Dibenzosuberenone >98.0%(GC)	2222-33-5	25g	$64	2026-04-30	Buy
Biosynth	FD21530	5-Dibenzosuberenone	2222-33-5	1kg	$900	2026-06-04	Buy
Biosynth	FD21530	5-Dibenzosuberenone	2222-33-5	0.5kg	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
D31737	25g	$204	Buy
D31737	100g	$210	Buy
D1791	25g	$64	Buy
FD21530	1kg	$900	Buy
FD21530	0.5kg	$900	Buy

5-Dibenzosuberenone Chemical Properties,Uses,Production

Chemical Properties

5-Dibenzosuberenone is white to pale yellow or beige crystalline powder

Uses

5-Dibenzosuberenone Can be used in the synthesis of a series of potent antidepressants.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 8, p. 886, 1965 DOI: 10.1021/jm00330a044

Synthesis

Method 1: Dibenzo[a,d]cycloheptan-5-one was used as the starting material, and the target product was prepared by bromine bromination reflux reaction in CCl4 for 18h, followed by addition of triethylamine and then continued reflux for another 16h, and then after post-treatment. This method uses more toxic raw materials and the preparation reaction period is also longer.

Method 2: Using trans-dibromo-substitute as the substrate, the target product was prepared by reacting under light radiation via a Schlenk tube device under the action of argon protection and -selenothiophene and tetramethylethylenediamine. The preparation of the target product of this method is in milligram scale and requires column chromatography for purification, which is difficult for mass production.

Method 3: The target product 5-dibenzocycloheptenone was prepared by intramolecular decarboxylation coupling of 3-(2-benzoylphenyl)acrylic acid as starting material under the effect of silver catalyst and oxidizing agent.

5-Dibenzosuberenone synthesis

Synthesis of 5-Dibenzosuberenone from DIBENZOSUBERENOL

5-Dibenzosuberenone Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide Ethanol AIBN N,N-Dimethylformamide Sodium sulfate

Carbon tetrachloride 1,5-Diazabicyclo[4.3.0]non-5-ene Benzene Ethyl acetate Hydrochloric acid

Dichloromethane Dibenzosuberone Pyridine Petroleum ether

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Preparation Products

DBCO-NHS Ester desmethylcyproheptadine

5-Dibenzosuberenone Suppliers

Global( 374)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5225	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21586	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Coresyn Pharmatech Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Anhui Ruihan Technology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Jinan Finer Chemical Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 5-Dibenzosuberenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	5-Dibenzosuberenone 2222-33-5	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	5-Dibenzosuberenone 2222-33-5	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	5-Dibenzosuberenone 2222-33-5		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

5-Dibenzosuberenone
2222-33-5
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

5-Dibenzosuberenone
2222-33-5
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Dibenzosuberenone
2222-33-5
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

5-Dibenzosuberenone Spectrum

5-Dibenzosuberenone(2222-33-5)MS 5-Dibenzosuberenone(2222-33-5)¹HNMR 5-Dibenzosuberenone(2222-33-5)¹³CNMR 5-Dibenzosuberenone(2222-33-5)IR1 5-Dibenzosuberenone(2222-33-5)IR2 5-Dibenzosuberenone(2222-33-5)Raman

2222-33-5(5-Dibenzosuberenone)Related Search:

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DIETHYLPROPION TROPONE CYCLOHEPTENE Cycloheptatriene Dibenzosuberone

DIBENZOSUBERYL CHLORIDE CIS-STILBENE 2-METHYLSTYRENE 5H-dibenzo[a,d]cycloheptene 1-ETHYL-2-VINYL-BENZENE

5-Dibenzosuberenone 2,3:6,7-DIBENZOSUBERENONE CYPROHEPTADINE HYDROCHLORIDE IMP. B (EP): 5H-DIBENZO[A,D]CYCLOHEPTEN-5-ONE (DIBENZOSUBERENONE)

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Cyproheptadine Impurity B Cyproheptadine impurity B (5h-dibenzo A, D cycloheptene-5-one) 5H-DIBENZO[A,D]CYCLOHEPTEN-5-ONE 5H-DIBENZO(A,D)CYCLOHEPTENE-5-OL 5-DIBENZOSUBERENONE Dibenzosuberenone,97% NSC 86151 Cyclobenzaprine Dibenzosuberenone IMpurity Cyproheptadine IMpurity B (Dibenzosuberenone) 5-Dibenzosuberenone, 98%+ 5-Dibenzosuberenone 97% dibenzo[1,2-a:1',2'-e][7]annulen-11-one 5-Dibenzosuberenone≥ 99% (GC) 5H-Dibenzo[α,δ]cyclohepten-5-one DIBENZOSUBERENONE-5 DIBENZO[A,D]-CYCLOHEPTENE-5-ONE DIBENZO[A,B] CYCLOHEPTEN-5-ONE 2,3,6,7-Dibenzotropone 2,3:6,7-Dibenzosuberen-4-on-1 2,3:6,7-Dibenzotropone 5H-Dibenzo[,d]cyclohepten-5-one 5H-Dibenzo[a,d]cycloheptenone Dibenzo[,d]cycloheptatrien-5-one H-Dibenzo(a,d)cyclohepten-5-one 5H-dibenzo[a,d][7]annulen-5-one dibenzo[b,f]cyclohepten-1-one 5H-DIBENZO[A,D]CYCLOHEPTENE-5-ONE Dibenzosberenone Cyproheptad impurity B (non-specific state) 5-dibenzocycloheptenone 5H-Dibenzo[a,d]cyclohepten-5-one (D Dibenzosuberenone> 5H-Dibenzo[a,d][7]annulen-5-one,>98% dibenzo[1,2-a:1',2'-e][7]annulen-1one ibenzo[1,2-a:1',2'-e][7]annulen-11-one Dibenzo[b,f]cyclohepten-1-on 5-Dibenzosuberenone (Polpharma customer) Cyproheptadine Impurity 6 Cyproheptadine Impurity 6 (Dibenzosuberenone) Dibenzo[a,d]cyclohepten-5-one DIBENZOSUBERENONE 2222-33-5 Organic Building Blocks Ketones Building Blocks C15 to C38 Carbonyl Compounds Others chemical reagents Aromatics Intermediates API intermediates intermediate of cyclobenzaprine, cyproheptadine, d Pharmaceutical Intermediates