2',4',6'-Trihydroxyacetophenone monohydrate
- CAS No.
- 480-66-0
- Chemical Name:
- 2',4',6'-Trihydroxyacetophenone monohydrate
- Synonyms
- THAP;Phloracetophenone;PHLOROACETOPHENONE;1-(2,4,6-trihydroxyphenyl)ethan-1-one;Phloracetophene;Monoacetylphloroglucinol;2-Acetylphloroglucinol hydrate;2,4,6-trihydroxylacetophenone monohydrate;NSC 54927;Acetophloroglucine
- CBNumber:
- CB2333652
- Molecular Formula:
- C8H8O4
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD00002287
- MOL File:
- 480-66-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 219-221 °C(lit.) |
|---|---|
| Boiling point | 257.07°C (rough estimate) |
| Density | 1.3037 (rough estimate) |
| refractive index | 1.5090 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly), Water (Very Slightly, |
| pka | 7.76±0.23(Predicted) |
| form | Powder |
| color | light yellow |
| Water Solubility | Soluble in water. |
| BRN | 1911197 |
| Stability | Stable under recommended storage conditions., Stable Under Recommended Storage C |
| InChI | 1S/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3 |
| InChIKey | XLEYFDVVXLMULC-UHFFFAOYSA-N |
| LogP | 1.472 (est) |
| CAS DataBase Reference | 480-66-0(CAS DataBase Reference) |
| FDA UNII | 8L7XD8830T |
| NIST Chemistry Reference | Ethanone, 1-(2,4,6-trihydroxyphenyl)-(480-66-0) |
| EPA Substance Registry System | Ethanone, 1-(2,4,6-trihydroxyphenyl)- (480-66-0) |
| UNSPSC Code | 12352115 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AN0528000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29145000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2',4',6'-Trihydroxyacetophenone monohydrate price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T1888 | 2',4',6'-Trihydroxyacetophenone Monohydrate >98.0%(GC) | 480-66-0 | 5g | $134 | 2026-04-30 | Buy |
| TCI Chemical | T1888 | 2',4',6'-Trihydroxyacetophenone Monohydrate >98.0%(GC) | 480-66-0 | 25g | $415 | 2026-04-30 | Buy |
| Cayman Chemical | 19451 | Monoacetylphloroglucinol ≥98% | 480-66-0 | 5g | $29 | 2021-12-16 | Buy |
| Cayman Chemical | 19451 | Monoacetylphloroglucinol ≥98% | 480-66-0 | 10g | $49 | 2021-12-16 | Buy |
| Usbiological | 289787 | 2',4',6'-Trihydroxyacetophenone hydrate Asreported | 480-66-0 | 5g | $320 | 2026-06-03 | Buy |
2',4',6'-Trihydroxyacetophenone monohydrate Chemical Properties, Uses, Production
Chemical Properties
Light Brown Solid
Uses
Monoacetylphloroglucinol (MAPG) is small molecular weight phenolic metabolite belonging to the phloroglucinol (1,3,5-trihydroxybenzene) family, produced by bacteria including Pseudomonas strains. MAPG exhibits a broad range of biological activity albeit with mostly low potency. In the search for novel actives, MAPG and related metabolites are important metabolites for dereplication to eliminate leads due to high amounts of weakly potent actives. Although weakly active, this family appears to be important in the biocontrol of plant diseases by some Pseudomonas strains.
Uses
Induced choleresis in rats is mediated through multidrug resistance protein-2 (Mrp2). It enhances bile secretion.
Definition
ChEBI: A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acid c glycans and glycopeptides.
Preparation
Preparation by reaction of acetic anhydride on phloroglucinol,
with concentrated sulfuric acid at 130° (70%)
with boron trifluoride at 10° (62.5–68%)
with zinc chloride at 145–150° (50%)
with Amberlite IR-120 or Zeokarb 225 (cation exchange resins, sulfonic acid type) at 160° (39%).
Biological Activity
monoacetylphloroglucinol (mapg), small molecular weight phenolic metabolite, is produced via bacteria including pseudomonas strains. mapg is acetylated to form the broad-spectrum antibiotic, 2,4-diacetylphloroglucinol (dapg) by mapg acetyltransferase. in addition, mapg exerts fairly weak potency when exhibiting a broad range of antibiotic activity. even though weakly active, it seems that mapg is essential in the biocontrol of plant diseases by some pseudomonas strains [1].
target
HMG-CoA Reductase
Purification Methods
Crystallise the ketone from hot H2O (35mL/g). [Beilstein 8 IV 2729.]
References
[1]. hayashi, a., saitou, h., mori, t., matano, i., sugisaki, h., & maruyama, k. molecular and catalytic properties of monoacetylphloroglucinol acetyltransferase frompseudomonassp. ygj3. bioscience, biotechnology, and biochemistry. 2012; 76(3): 559-566.
2',4',6'-Trihydroxyacetophenone monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Haifang Biotechnology Co., Ltd. | 17661093587 | 3917957412@qq.com | China | 44 | 58 |
| Weifang Siyuan Chemical Co., Ltd. | 0536-8888106 17663601818 | 2354379876@qq.com | China | 244 | 58 |
| XUZHOU RUISAI BIOCHEMICAL TECHNOLOGY CO.,LTD. | -- | 2246953955@qq.com | China | 12 | 58 |
| Shandong RuiYue Biotechnology Co., Ltd. | 0531-88581623 18805314509 | 1456922171@126.com | China | 63 | 50 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 2',4',6'-Trihydroxyacetophenone monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 2-Acetylphloroglucinol hydrate
480-66-0
|
$1.00-100.00 | 1KG | 95% | 300KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-07-14 | Phloracetophenone
480-66-0
|
$29.00 | 99.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | 2',4',6'-Trihydroxyacetophenone monohydrate
480-66-0
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-Acetylphloroglucinol hydrate
480-66-0
- $1.00-100.00
- 95%
- Shaanxi Dideu Medichem Co. Ltd
-
- Phloracetophenone
480-66-0
- $29.00
- 99.57%
- TargetMol Chemicals Inc.
-
- 2',4',6'-Trihydroxyacetophenone monohydrate
480-66-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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