NucPE1
- CAS No.
- 1404091-23-1
- Chemical Name:
- NucPE1
- Synonyms
- NucPE1;NUCPE1?, >98%;Nuclear Peroxy Emerald 1;Nuclear Peroxy Emerald 1, >98%;3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9'-xanthene]-1-one;Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB23339684
- Molecular Formula:
- C29H30BNO5
- Molecular Weight:
- 483.36
- MDL Number:
- MFCD31544335
- MOL File:
- 1404091-23-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
NucPE1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | EGC09123 | NucPE1 | 1404091-23-1 | 5mg | $1316.8 | 2026-06-04 | Buy |
| Biosynth | EGC09123 | NucPE1 | 1404091-23-1 | 10mg | $1832 | 2026-06-04 | Buy |
| Biosynth | EGC09123 | NucPE1 | 1404091-23-1 | 25mg | $3435.25 | 2026-06-04 | Buy |
| Biosynth | EGC09123 | NucPE1 | 1404091-23-1 | 50mg | $5496.5 | 2026-06-04 | Buy |
| ChemScene | CS-7002 | NucPE1 98.0% | 1404091-23-1 | 5mg | $585 | 2026-06-04 | Buy |
NucPE1 Chemical Properties, Uses, Production
Uses
NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.
in vivo
NucPE1 maintains the ability to selectively target nuclei in vivo. NucPE1 imaging reveals a reduction in nuclear H2O2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools[1].
References
[1] Stanicka J, et al. NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells. J Biol Chem. 2015 Apr 10;290(15):9348-61. DOI:10.1074/jbc.M113.510495
[2] Dickinson BC, et al. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. Chem Biol. 2011 Aug 26;18(8):943-8. DOI:10.1016/j.chembiol.2011.07.005
NucPE1 Preparation Products And Raw materials
Raw materials
Preparation Products
NucPE1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Shanghai kadel chemical technology co., LTD | 021-4007787-550 400-7787-550 | 2850202386@qq.com | China | 10569 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Henan Weitixi Chemical Technology Co., Ltd | 0371-53370800 18037197114 | 3807961510@qq.com | China | 9957 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
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