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Semaglutide intermediate

Semaglutide intermediate Structure
Semaglutide intermediate structure
CAS No.
1118767-15-9
Chemical Name:
Semaglutide intermediate
Synonyms
Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OSu;tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu;tBuO-C18-Glu(AEEA-AEEA-OSu)-OtBu;tBuO-Ste-rGlu(OtBu)-AEEA-AEEA-OSu;tBuO-C18-γ-Glu(AEEA-AEEA-OSu)-OtBu;21,39-di-tert-Butyl 1-(2,5-dioxopyrrolidin-1-yl) (S)-9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate;Carbaryl Impurity 1;tBuO-Ste-yGlu(OtBu)-;Somalutide side chain;Semaglutide Impurity 17
CBNumber:
CB23352999
Molecular Formula:
C47H82N4O15
Molecular Weight:
943.17
MDL Number:
MFCD32661370
MOL File:
1118767-15-9.mol
MSDS File:
SDS
Last updated:2026-07-14 10:47:14
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Semaglutide intermediate Properties

Density 1.15±0.1 g/cm3(Predicted)
pka 14.18±0.46(Predicted)
InChIKey ZYJILBKLUVJVKQ-QNGWXLTQSA-N
SMILES C(ON1C(=O)CCC1=O)(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](C(OC(C)(C)C)=O)NC(=O)CCCCCCCCCCCCCCCCC(OC(C)(C)C)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338

Semaglutide intermediate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 297874 (S)-21,39-Di-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate 1118767-15-9 250.00mg $89 2026-05-19 Buy
Iris Biotech GmbH OAA1010 21,39-di-t-butyl 1-(2,5-dioxopyrrolidin-1-yl) (S)-9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate 1118767-15-9 1g $456 2026-05-19 Buy
Matrix Scientific 297874 (S)-21,39-Di-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate 1118767-15-9 1.00g $226 2026-05-19 Buy
Iris Biotech GmbH OAA1010 21,39-di-t-butyl 1-(2,5-dioxopyrrolidin-1-yl) (S)-9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate 1118767-15-9 5g $1104 2026-05-19 Buy
Matrix Scientific 297874 (S)-21,39-Di-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate 1118767-15-9 5.00g $779 2026-05-19 Buy
Product number Packaging Price Buy
297874 250.00mg $89 Buy
OAA1010 1g $456 Buy
297874 1.00g $226 Buy
OAA1010 5g $1104 Buy
297874 5.00g $779 Buy

Semaglutide intermediate Chemical Properties, Uses, Production

Purity

98%

Description

Semaglutide intermediates play a crucial role in the synthesis and development of Semaglutide, a potent GLP-1 receptor agonist. ​

Uses

Semaglutide intermediate is an intermediate of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes.

General Description

High-purity (98%) semaglutide intermediate (CAS 1118767-15-9), also known as tBuO-Ste-Glu(OtBu)-AEEA-AEEA-OSU, (S)-21,39-tBuO-Ste-Glu(OtBu)-AEEA-AEEA-OSU and Semaglutide Impurity 17, is a white to off-white powder. It is a key intermediate in the solid-phase synthesis of semaglutide and is used in the drug modification of semaglutide. The AEEA-AEEA functional groups in its molecule help to improve the drug’s solubility and stability.

Synthesis

Somalutide side chain is synthesized from tetradecanedioic acid by condensation, reduction, ring-opening and Boc monoprotection of first synthesizing the intermediate mono-tert-butyl octadecanedioate, and then by further condensation reaction of the intermediate.

Semaglutide intermediate Preparation Products And Raw materials

Raw materials

Preparation Products

Semaglutide

Semaglutide intermediate Suppliers

Global Suppliers ( 129)
Supplier Tel Email Country ProdList Advantage
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 2223443625@qq.com China 7998 58
Zhejiang Bolang New Material Co., LTD 18967100450 jimmy@bolangchem.cn China 50 58
Ji'nan tengbang pharmaceutical science and Technology Co., Ltd. 0531-88763264 2685550793@qq.com China 124 58
HASWELL 13951186658 Haswellvip@gmail.com China 115 58
Suzhou Chukai PharmaTech 0512-88812066 wenlongfcb@qq.com China 470 58
Shanghai HongTide Biotechnology Co.,Ltd. 15318089928 alex@hanhonggroup.com China 4604 58
Shanghai Yanfen Biochemical Technology Co.,LTD 13611955358 15002190549 yanfen2023@126.com China 2573 58
Shanghai Baoda Biotechnology Co., Ltd. 15900974796 gjzhu@blpharm.net China 197 58
Alabiochem Tech.Co., Ltd. 512-58900862 400-0707518 sales@alabiochem.com China 988 59
Sichuan Tongsheng Amino acids Co.,Ltd. 0838-2274206 17340404235 sales@biots.cn China 300 66
Supplier Advantage
Hubei Kele Fine Chemical Co., Ltd 58
Zhejiang Bolang New Material Co., LTD 58
Ji'nan tengbang pharmaceutical science and Technology Co., Ltd. 58
HASWELL 58
Suzhou Chukai PharmaTech 58
Shanghai HongTide Biotechnology Co.,Ltd. 58
Shanghai Yanfen Biochemical Technology Co.,LTD 58
Shanghai Baoda Biotechnology Co., Ltd. 58
Alabiochem Tech.Co., Ltd. 59
Sichuan Tongsheng Amino acids Co.,Ltd. 66

View Latest Price from Semaglutide intermediate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Semaglutide intermediate pictures 2026-09-02 Semaglutide intermediate
1118767-15-9
 $1.00-2.00 1KG 99% Henan Fengda Chemical Co., Ltd
Semaglutide intermediate pictures 2026-08-25 Semaglutide intermediate
1118767-15-9
 $60.00 10kg 0.99 30tons Zibo Hangyu Biotechnology Development Co., Ltd
tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu pictures 2026-07-24 tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu
1118767-15-9
 1g 98% 1g/bottle , 10g/bottle, 100g/bottle XIAMEN SINOPEG BIOTECH CO., LTD.

1118767-15-9 (Semaglutide intermediate) Related Search:

Semaglutide tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Octadecanedioic acid 6-Chloro-3-indoxyl-beta-D-glucopyranoside trihydrate 6-Chloro-3-indoxyl-beta-D-glucopyranoside trihydrate
18-(tert-butoxy)-18-oxooctadecanoic acid L-Glutamic acid α-tert-butyl ester Boc-His(Trt)-Aib-OH Boc-NH-PEG2-CH2COOH Fmoc-8-amino-3,6-dioxaoctanoic acid

1of2

Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OSu 3,6,12,15-Tetraoxa-9,18,23-triazahentetracontanedioic acid, 22-[(1,1-dimethylethoxy)carbonyl]-10,19,24-trioxo-, 41-(1,1-dimethylethyl) 1-(2,5-dioxo-1-pyrrolidinyl) ester, (22S)- 17-((S)-1-tert-Butoxycarbonyl-3-{2-[2-({2-[2-(2,5-dioxopyrrolidin-1-yloxycarbonylmethoxy)ethoxy]ethylcarbamoyl}methoxy)ethoxy]-ethylcarbamoyl}propylcarbamoyl)heptadecanoic acid tert-butyl ester tBuO-Ste-γGlu(OtBu)-AEEA-AEEA-OSu tert-butyl 18-[[(2S)-5-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-[(2-methylpropan-2-yl)oxy]-1,5-dioxopentan-2-yl]amino]-18-oxooctadecanoate tBuO-Ste-yGlu(OtBu)- tBuO-Ste-E(AEEA-AEEA-OSu)-OtBu tBuO-C18-y-Glu(AEEA-AEEA-OSu)-OtBu Somalutide side chain tBuO-C18-γGlu(tBu)-AEEA-AEEA-OSU Octa(OtBu)-Glu(AEEA-AEEA-OSu)-OtBu Carbaryl Impurity 1 Semaglutide Impurity 17 Semaglutide Impurity 45 OtBu-C18-Glu(OtBu)-AEEA-AEEA-NHS、tBuO-Ste-Glu(OtBu)-AEEA-AEEA-OSU 21,39-di-tert-Butyl 1-(2,5-dioxopyrrolidin-1-yl) (S)-9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu tBuO-C18-Glu(AEEA-AEEA-OSu)-OtBu tBuO-Ste-rGlu(OtBu)-AEEA-AEEA-OSu tBuO-C18-γ-Glu(AEEA-AEEA-OSu)-OtBu tBuO-Ste-Glu(OtBu)-AEEA-AEEA-OSu Bis(2-methyl-2-propanyl)1-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,10,19,24-tetraoxo-3,6,12,15-triazatetracosane-22,40-dicarboxylate 1118767-15-9 118767-16-0 C47H82N4O15