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Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid structure

CAS No.: 166108-71-0

Chemical Name:: Fmoc-8-amino-3,6-dioxaoctanoic acid

Synonyms: FMOC-AEEA-OH;FMOC-AEEA;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMOC-AEEAC-OH;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;Fmoc-Ado-OH;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID

CBNumber:: CB2169923

Molecular Formula:: C21H23NO6

Molecular Weight:: 385.41

MDL Number:: MFCD01321015

MOL File:: 166108-71-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:12

Product description	Number	Pack Size	Price
{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid ≥95.0% (HPLC)	95003	500mg	$257
Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem?	8.51037	1g	$495
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	F0719	1g	$225
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	F0719	200mg	$76
Fmoc-NH-PEG2-CH2COOH 98%	bp-22044	250MG	$60
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Fmoc-8-amino-3,6-dioxaoctanoic acid Properties

Melting point	90-92℃
Boiling point	631.4±45.0 °C(Predicted)
Density	1.265±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	3.40±0.10(Predicted)
form	Crystalline Powder
color	White
InChI	InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey	XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES	C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference	166108-71-0(CAS DataBase Reference)
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P271-P261-P280

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

29189900

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

Fmoc-8-amino-3,6-dioxaoctanoic acid price More Price(95)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	95003	{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid ≥95.0% (HPLC)	166108-71-0	500mg	$257	2026-04-30	Buy
Sigma-Aldrich	8.51037	Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem?	166108-71-0	1g	$495	2026-04-30	Buy
TCI Chemical	F0719	8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	166108-71-0	1g	$225	2026-04-30	Buy
TCI Chemical	F0719	8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	166108-71-0	200mg	$76	2026-04-30	Buy
BroadPharm	bp-22044	Fmoc-NH-PEG2-CH2COOH 98%	166108-71-0	250MG	$60	2026-05-24	Buy

Product number	Packaging	Price	Buy
95003	500mg	$257	Buy
8.51037	1g	$495	Buy
F0719	1g	$225	Buy
F0719	200mg	$76	Buy
bp-22044	250MG	$60	Buy

Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Uses,Production

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

Hydrophillic spacer group.

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

reaction suitability

reagent type: cross-linking reagent

Fmoc-8-amino-3,6-dioxaoctanoic acid synthesis

Synthesis of Fmoc-8-amino-3,6-dioxaoctanoic acid from 9-Fluorenylmethyl chloroformate and 2-(2-(2-Aminoethoxy)ethoxy)acetic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials

Raw materials

Phthalimide Triethylene glycol Hydrazinium hydroxide solution N,N-Dimethylformamide Potassium carbonate

Chromium(VI) oxide Triethylamine Tosyl chloride DBU 9-Fluorenylmethyl chloroformate

Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide Fmoc-OSu

Sulfuric acid

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Preparation Products

Fmoc-8-amino-3,6-dioxaoctanoic acid Suppliers

Global( 504)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co.,Ltd.	+86-0512-68071238 +86-13771819922	june@highfine.com	China	489	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+8618382028708	ni@enlaibio.com	China	1100	58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	+8615065888978	admin@hsnordpharma.com	China	92	58
XIAMEN SINOPEG BIOTECH CO., LTD.	+86-0592-7761068 +8617350879715	changaiwei@sinopeg.com	China	1125	58
Ningxia LabsChem Co., Ltd.	0952-9294929 +8613895679378	48472788@qq.com	China	352	58
Suzhou Chukai Pharma Tech Co.,Ltd	+86-15151706780; +8615062531973	2279973922@qq.com	China	404	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Chengdu ZY Biochemical Technology Co., Ltd.	+86-86-2888626688 +8618980008884	xuehaiying@zybiochem.com	China	177	58
Shandong Juntai Pharmaceutical Co. , Ltd.	+8615106953682	sales@h2opharm.com	China	189	58
LAURENT	+8618100176782	sun@laurentpeg.com	China	365	58

Supplier	Advantage
Suzhou Highfine Biotech Co.,Ltd.	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	58
XIAMEN SINOPEG BIOTECH CO., LTD.	58
Ningxia LabsChem Co., Ltd.	58
Suzhou Chukai Pharma Tech Co.,Ltd	58
Aladdin Scientific	58
Chengdu ZY Biochemical Technology Co., Ltd.	58
Shandong Juntai Pharmaceutical Co. , Ltd.	58
LAURENT	58

View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-25	Fmoc-AEEA-OH 166108-71-0	US $0.00-0.00 / kg	0.10000000149011612kg	98%;99%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-05-05	[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 166108-71-0	US $60.00-600.00 / KG	1KG	0.99	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2026-02-05	8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid 166108-71-0	US $0.00-0.00 / g	1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.

Fmoc-AEEA-OH
166108-71-0
US $0.00-0.00 / kg
98%;99%
Sichuan HongRi Pharma-Tech Co.,Ltd

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
166108-71-0
US $60.00-600.00 / KG
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid
166108-71-0
US $0.00-0.00 / g
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

Fmoc-8-amino-3,6-dioxaoctanoic acid Spectrum

Fmoc-8-amino-3,6-dioxaoctanoic acid(166108-71-0)¹HNMR Fmoc-8-amino-3,6-dioxaoctanoic acid(166108-71-0)FT-IR

166108-71-0(Fmoc-8-amino-3,6-dioxaoctanoic acid)Related Search:

6-Aminocaproic acid 2-Aminothiazole-4-acetic acid 4-Aminophenylacetic acid Nitrilotriacetic acid DIETHOXYMETHANE

Ethoxyethyne Ethoxyquin Fmoc-Phe-OH METHOXYCARBONYLSULFENYL CHLORIDE Fmoc-Lys(Boc)-OH

Ethyl 2-(Chlorosulfonyl)acetate 9-Fluorenylmethyl chloroformate Iminodiacetic acid Ethoxyamine hydrochloride Fmoc-OSu

Glycine FMOC-THR(TBU)-OL 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid

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Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA Fmoc-PEG2-acetic acid {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC) Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID 8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID 8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID FMOC-O2OC-OH FMOC-MINI-PEG(TM) FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren 8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID Fmoc-PEG2- CH2COOH (Fmoc-AEEA) 6-dioxaoctanoic acid Fmoc-8-amino-3 Fmoc-NH-(PEG)-COOH (9 atoms) MOC-AEEAC-OH [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0% 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA 2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid {2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5% {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid RARECHEM EM WB 0032 Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA 1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid (2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID (2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid> 3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo- Fmoc-AEEA/Fmoc-Mini-PEG N-formylglycine t-butylester 2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP Fmoc-N-Amido-PEG2-CH2COOH Fmoc-N-amido-PEG2-acetic acid Fluorene methoxycarbonyl dipolyethylene glycol acetic acid Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) Fmoc-N-Me-Val/D-Val Fmoc-mini-PEG? Fmoc-8-Amino-3,6-Dioxaoctanoic Acid 8-(Fmoc-amino)-3,6-dioxaoctanoic acid 98% FMOC-AEEA FMOC-AEEAC-OH 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid FMOC-AEEA-OH FMoc-NH-PEG2-CH2COOH FMOC-AEEAC Fmoc-Ado-OH