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Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid structure

CAS No.: 166108-71-0

Chemical Name:: Fmoc-8-amino-3,6-dioxaoctanoic acid

Synonyms: FMOC-AEEA-OH;FMOC-AEEA;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMOC-AEEAC-OH;FMoc-NH-PEG2-CH2COOH;Fmoc-Ado-OH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID

CBNumber:: CB2169923

Molecular Formula:: C21H23NO6

Molecular Weight:: 385.41

MDL Number:: MFCD01321015

MOL File:: 166108-71-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-29 21:06:38

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Fmoc-8-amino-3,6-dioxaoctanoic acid Properties

Melting point	90-92℃
Boiling point	631.4±45.0 °C(Predicted)
Density	1.265±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	3.40±0.10(Predicted)
form	Crystalline Powder
color	White
InChI	InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey	XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES	C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference	166108-71-0(CAS DataBase Reference)
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P271-P261-P280

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

29189900

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

Fmoc-8-amino-3,6-dioxaoctanoic acid price More Price(129)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	95003	{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid ≥95.0% (HPLC)	166108-71-0	500mg	$257	2026-04-30	Buy
Sigma-Aldrich	8.51037	Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem?	166108-71-0	1g	$495	2026-04-30	Buy
TCI Chemical	F0719	8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	166108-71-0	1g	$225	2026-04-30	Buy
TCI Chemical	F0719	8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	166108-71-0	200mg	$76	2026-04-30	Buy
Usbiological	276699	{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid Asreported	166108-71-0	500mg	$360	2026-06-03	Buy

Product number	Packaging	Price	Buy
95003	500mg	$257	Buy
8.51037	1g	$495	Buy
F0719	1g	$225	Buy
F0719	200mg	$76	Buy
276699	500mg	$360	Buy

Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties, Uses, Production

Preparation

Nitrogen atom protection is achieved by reacting benzaldehyde with diethylene glycolamine to form an imine, which then reacts with tert-butyl bromoacetate to form an ether. Subsequent deaminoprotection and ester hydrolysis are accomplished through a one-pot reaction in acidic water with stirring overnight. Finally, Fmoc is added to the amino group to yield Fmoc-8-amino-3,6-dioxaoctanoic acid.

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

Hydrophillic spacer group.

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

reaction suitability

reagent type: cross-linking reagent

Fmoc-8-amino-3,6-dioxaoctanoic acid synthesis

Synthesis of Fmoc-8-amino-3,6-dioxaoctanoic acid from 9-Fluorenylmethyl chloroformate and 2-(2-(2-Aminoethoxy)ethoxy)acetic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials

Raw materials

Phthalimide Triethylene glycol Hydrazinium hydroxide solution N,N-Dimethylformamide Potassium carbonate

Chromium(VI) oxide Triethylamine Tosyl chloride DBU 9-Fluorenylmethyl chloroformate

Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide Fmoc-OSu

Sulfuric acid

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Preparation Products

Fmoc-8-amino-3,6-dioxaoctanoic acid Suppliers

Global Suppliers ( 519)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	473	75
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58
CAS Aldone(Dalian) Pharmaceutical Science and Technology Co, Ltd.	86-13062552990 13062552990	sales@casaldone.com	China	279	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
Jiangsu Jitai Peptide Technology Co., Ltd.	051580855066 13770132022	sales05@gtaipeptide.com	China	2675	58
Binhai gill polypeptide co. LTD	021-61263389 13524856427	Joetang@glschina.com	China	9927	58
Shandong Juntai Pharmaceutical Co. LTD	18615688519; 18963498209	juntai@h2opharm.com	China	294	58
Chengdu Tachem Co., Ltd	028-61682518; 19983060238	sales@tachem.cn	China	102	58
CHENGDU YINGNUOLING PHARMACEUTICAL TECHNOLOGY CO.,LTD	17882285575	1276966012@qq.com	China	399	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Suzhou Highfine Biotech Co., Ltd	75
Hangzhou Peptidego Biotech Co.,Ltd.	58
CAS Aldone(Dalian) Pharmaceutical Science and Technology Co, Ltd.	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
Jiangsu Jitai Peptide Technology Co., Ltd.	58
Binhai gill polypeptide co. LTD	58
Shandong Juntai Pharmaceutical Co. LTD	58
Chengdu Tachem Co., Ltd	58
CHENGDU YINGNUOLING PHARMACEUTICAL TECHNOLOGY CO.,LTD	58
J & K SCIENTIFIC LTD.	76

View Latest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	Fmoc-AEEA-OH 166108-71-0			98%;99%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-08-25	[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 166108-71-0	$60.00-600.00	1KG	0.99	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2026-07-24	8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid 166108-71-0		1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.

Fmoc-AEEA-OH
166108-71-0
98%;99%
Sichuan HongRi Pharma-Tech Co.,Ltd

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
166108-71-0
$60.00-600.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid
166108-71-0
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

Fmoc-8-amino-3,6-dioxaoctanoic acid Spectrum

Fmoc-8-amino-3,6-dioxaoctanoic acid(166108-71-0)¹HNMR Fmoc-8-amino-3,6-dioxaoctanoic acid(166108-71-0)FT-IR

166108-71-0 (Fmoc-8-amino-3,6-dioxaoctanoic acid) Related Search:

6-Aminocaproic acid 2-Aminothiazole-4-acetic acid 4-Aminophenylacetic acid Nitrilotriacetic acid Ethoxyethyne

Iminodiacetic acid Ethoxyquin Fmoc-Phe-OH Ethyl 2-(Chlorosulfonyl)acetate 9-Fluorenylmethyl chloroformate

Ethoxyamine hydrochloride Fmoc-Lys(Boc)-OH Fmoc-OSu Glycine Diethoxymethane

Methoxycarbonylsulfenyl chloride Fmoc-Thr(tBu)-ol 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid

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Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA Fmoc-PEG2-acetic acid {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC) Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID 8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID 8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID FMOC-O2OC-OH FMOC-MINI-PEG(TM) FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren 8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID Fmoc-PEG2- CH2COOH (Fmoc-AEEA) 6-dioxaoctanoic acid Fmoc-8-amino-3 Fmoc-NH-(PEG)-COOH (9 atoms) MOC-AEEAC-OH [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0% 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA 2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid {2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5% {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid RARECHEM EM WB 0032 Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA 1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid (2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID (2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid> 3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo- Fmoc-AEEA/Fmoc-Mini-PEG N-formylglycine t-butylester 2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP Fmoc-N-Amido-PEG2-CH2COOH Fmoc-N-amido-PEG2-acetic acid Fluorene methoxycarbonyl dipolyethylene glycol acetic acid Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) Fmoc-N-Me-Val/D-Val Fmoc-mini-PEG? Fmoc-8-Amino-3,6-Dioxaoctanoic Acid 8-(Fmoc-amino)-3,6-dioxaoctanoic acid 98% moc-8-amino-3,6-dioxaoctanoic acid FmocNH-PEG2-AA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid FMOC-AEEA FMOC-AEEAC-OH FMOC-AEEA-OH FMOC-AEEAC