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Boc-NH-PEG2-CH2COOH

Boc-NH-PEG2-CH2COOH structure

CAS No.: 108466-89-3

Chemical Name:: Boc-NH-PEG2-CH2COOH

Synonyms: Boc-AEEA-OH;2,2-DiMethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid;Boc-N-amido-PEG2-CH2CO2H;2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylaMino]ethoxy]ethoxy]acetic acid;Boc-O 2 Oc-OH;2-diMethyl-4-oxo-;BocNH-PEG2-CH2COOH;NHBoc-PEG2-CH2COOH;t-Boc-N-amido-PEG2-CH2CO2H;t-Boc-N-Amido-PEG2-CH2COOH

CBNumber:: CB02639228

Molecular Formula:: C11H21NO6

Molecular Weight:: 263.29

MDL Number:: MFCD17019374

MOL File:: 108466-89-3.mol

MSDS File:: SDS

Last updated:2026-05-27 17:37:32

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Boc-NH-PEG2-CH2COOH Properties

Boiling point	425.7±30.0 °C(Predicted)
Density	1.145±0.06 g/cm3(Predicted)
storage temp.	-20°C
pka	3.40±0.10(Predicted)
form	liquid
color	Yellow
InChI	InChI=1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)
InChIKey	OMBVJVWVXRNDSL-UHFFFAOYSA-N
SMILES	C(O)(=O)COCCOCCNC(=O)OC(C)(C)C
UNSPSC Code	51171641
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	WGK 3
HS Code	2918999090
Storage Class	10 - Combustible liquids

Boc-NH-PEG2-CH2COOH price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	901577	t-Boc-N-amido-PEG2-CH2CO2H ≥95%	108466-89-3	50MG	$39.3	2026-04-30	Buy
Biosynth	FN161445	N-(tert-Butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid	108466-89-3	5g	$900	2026-06-04	Buy
Biosynth	FN161445	N-(tert-Butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid	108466-89-3	50g	$900	2026-06-04	Buy
Biosynth	FN161445	N-(tert-Butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid	108466-89-3	2g	$900	2026-06-04	Buy
Biosynth	FN161445	N-(tert-Butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid	108466-89-3	25g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
901577	50MG	$39.3	Buy
FN161445	5g	$900	Buy
FN161445	50g	$900	Buy
FN161445	2g	$900	Buy
FN161445	25g	$900	Buy

Boc-NH-PEG2-CH2COOH Chemical Properties, Uses, Production

Description

t-Boc-N-amido-PEG2-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

t-Boc-N-amido-PEG₂-CH₂CO₂H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG₂-CH₂CO₂H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation.

reaction suitability

reagent type: linker

Synthesis

To a stirred solution of 2-(2-(2-Aminoethoxy)ethoxy)acetic acid (5.0 g, 30.6 mmol) in 1,4-Dioxane (50 mL), Sodium carbonate (8.12 g, 76.5 mmol, dissolved in 10 mL water) and (Boc)2O (9.98 mL, 45.7 mmol) were added and stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. The reaction mass was partitioned between diethyl ether and water. Then, the aqueous layer was made acidic (pH = 3) by 3N HC1 solution and was extracted with DCM (2 x 200 mL). The organic layer was washed with water, and brine, dried over Na2504 and evaporated under reduced pressure to yield 50 g of pure Boc-NH-PEG2-CH2COOH (Yield:62.1 per cent).

IC 50

PEGs; Alkyl/ether

References

[1] Organic and Biomolecular Chemistry, 2008, vol. 6, # 17, p. 3065 - 3078
[2] Patent: US2015/73042, 2015, A1. Location in patent: Paragraph 0150; 0151
[3] Patent: WO2015/33303, 2015, A1. Location in patent: Page/Page column 26; 27

Boc-NH-PEG2-CH2COOH synthesis

Synthesis of Boc-NH-PEG2-CH2COOH from Di-tert-butyl dicarbonate and Ethyl bromoacetate and 2-(2-Aminoethoxy)ethanol

Boc-NH-PEG2-CH2COOH Preparation Products And Raw materials

Raw materials

3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-, phenylmethyl ester 2-(2-(2-Aminoethoxy)ethoxy)acetic acid hydrochloride 2-(2-Boc-aminoethoxy)ethanol Bromoacetic acid Boc-8-amino-3,6-dioxaoctanoic acid dcha

2-(2-Aminoethoxy)ethanol Di-tert-butyl dicarbonate 2-(2-(2-Aminoethoxy)ethoxy)acetic acid Ethyl bromoacetate Iodoacetic acid sodium salt

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Preparation Products

Boc-NH-PEG2-CH2COOH Suppliers

Global Suppliers ( 217)

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Youbang Biomedical Technology Co., Ltd.	0913-7167565 13852786668	605375102@qq.com	China	212	58
CAS Aldone(Dalian) Pharmaceutical Science and Technology Co, Ltd.	86-13062552990 13062552990	sales@casaldone.com	China	279	58
CHENGDU YINGNUOLING PHARMACEUTICAL TECHNOLOGY CO.,LTD	17882285575	1276966012@qq.com	China	399	58
Shanghai Yanfen Biochemical Technology Co.,LTD	13611955358 15002190549	yanfen2023@126.com	China	2573	58
Hangzhou Xinjiayuan Biological Technology Co., LTD	18258867343; 15858275893	3275393843@qq.com	China	25	58
Changzhou Huanling Chemical Co., Ltd.	89803005 18206112582	info@huanlingchem.com	China	983	68
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Chembon Pharmaceutical Co., Ltd.	028-84252981 18583719936	sales@chembon.com.cn	China	854	64
Beijing Isomersyn Technology CO;LTD	010-82954736 13391601435	sales@isomersyn.com	China	3294	57

Supplier	Advantage
Shaanxi Youbang Biomedical Technology Co., Ltd.	58
CAS Aldone(Dalian) Pharmaceutical Science and Technology Co, Ltd.	58
CHENGDU YINGNUOLING PHARMACEUTICAL TECHNOLOGY CO.,LTD	58
Shanghai Yanfen Biochemical Technology Co.,LTD	58
Hangzhou Xinjiayuan Biological Technology Co., LTD	58
Changzhou Huanling Chemical Co., Ltd.	68
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Chembon Pharmaceutical Co., Ltd.	64
Beijing Isomersyn Technology CO;LTD	57

View Latest Price from Boc-NH-PEG2-CH2COOH manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-24	2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid 108466-89-3	1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.
2026-05-11	Boc-NH-PEG2-CH2COOH 108466-89-3			10g	TargetMol Chemicals Inc.
2026-01-28	BocNH-PEG2-CH2COOH 108466-89-3	1g	98%	100kg	LAURENT

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid
108466-89-3
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

Boc-NH-PEG2-CH2COOH
108466-89-3
$0.00
TargetMol Chemicals Inc.

BocNH-PEG2-CH2COOH
108466-89-3
98%
LAURENT

Boc-NH-PEG2-CH2COOH Spectrum

Boc-NH-PEG2-CH2COOH(108466-89-3)¹HNMR

108466-89-3 (Boc-NH-PEG2-CH2COOH) Related Search:

2,2-Dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-oic acid Boc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol O-(2-Aminoethyl)-O-(2-(Boc-amino)ethyl)octaethylene glycol O-(2-Aminoethyl)-O'-(2-(Boc-amino)ethyl)

N-Boc-PEG6-alcohol O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000 Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

15-(Boc-amino)-4,7,10,13-tetraoxapentadecanoic acid Z-8-aMino-3,6-dioxaoctanoic acid t-Boc-N-amido-PEG5-acid Boc-9-AMino-4,7-Dioxanonanoic acid 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester

t-Boc-N-amido-PEG2-acid t-Boc-N-amido-PEG1-acid Boc-NH-PEG2-CH2COOH

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t-boc-N-amido-PEG2-acetic acid 3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo- 8-tert-butyloxycarbonylaMino-3,6-dioxaoctanoic acid 2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylaMino]ethoxy]ethoxy]acetic acid t-Boc-N-amido-PEG2-CH2CO2H BocNH-PEG2-CH2COOH T-BOC-NH-AMIDO-PEG2-CH2CO2H 2-[2-[2-(Boc-amino)ethoxy]ethoxy]acetic Acid 2-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethoxy]acetic acid 3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo- 3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo- USP/EP/BP 11-Trioxa-5-azatridecan-13-oic acid 2-diMethyl-4-oxo- NHBoc-PEG2-CH2COOH t-Boc-N-Amido-PEG2-CH2COOH N-Boc-8-amino-3,6-dioxaoctanoic acid Boc-O 2 Oc-OH 2-[2-(2-([(tert-butoxy)carbonylaminoJethoxy)ethoxylacetic acid 2,2-dimethyl-4,13-dioxo-3,8,11-trioxa-5-azatetradecan-14-oic acid Boc-NH-PEG2-CH2COOH/Boc-AEEA-OH t-Boc-N-amido-PEG_2-CH₂CO₂H 2- [2- (tert butoxycarbonylamino) ethoxy] ethoxyacetic acid N-(tert-Butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid 2,2-DiMethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid Boc-AEEA-OH Boc-N-amido-PEG2-CH2CO2H 108466-89-3 137978-97-5 peg