4-Methoxy-2-methylphenylboronic acid
- CAS No.
- 208399-66-0
- Chemical Name:
- 4-Methoxy-2-methylphenylboronic acid
- Synonyms
- 2-methyl-4-methoxyphenylboronic acid;AKOS BRN-0221;4-Methoxy-2-methyL;4-Methoxy-2-Methylphenylboroni;4-Methoxy-2-methylphebylboronic acid;(4-methoxy-2-methylphenyl)boronicaci;4-Methoxy-2-methylphenylboronic acid;4-METHOXY-2-METHYLBENZENEBORONIC ACID;2-Methyl-4-methoxybenzeneboronic acid;B-(4-Methoxy-2-methylphenyl)boronic acid
- CBNumber:
- CB2344430
- Molecular Formula:
- C8H11BO3
- Molecular Weight:
- 165.98
- MDL Number:
- MFCD02684315
- MOL File:
- 208399-66-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 169-174 °C (lit.) |
|---|---|
| Boiling point | 327.1±52.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 9.03±0.58(Predicted) |
| form | Crystalline Solid |
| color | White |
| Water Solubility | Insoluble in water. |
| BRN | 8111222 |
| InChI | InChI=1S/C8H11BO3/c1-6-5-7(12-2)3-4-8(6)9(10)11/h3-5,10-11H,1-2H3 |
| InChIKey | AMSQNQJCBXQYEX-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(OC)C=C1C)(O)O |
| CAS DataBase Reference | 208399-66-0(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Methoxy-2-methylphenylboronic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 639370 | 4-Methoxy-2-methylphenylboronic acid | 208399-66-0 | 1g | $29.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 639370 | 4-Methoxy-2-methylphenylboronic acid | 208399-66-0 | 5g | $72.3 | 2023-06-20 | Buy |
| TCI Chemical | M2255 | 4-Methoxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride) | 208399-66-0 | 1g | $48 | 2026-04-30 | Buy |
| TCI Chemical | M2255 | 4-Methoxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride) | 208399-66-0 | 5g | $144 | 2026-04-30 | Buy |
| Apolloscientific | OR10527 | 4-Methoxy-2-methylbenzeneboronic acid >98% | 208399-66-0 | 5g | $21 | 2026-06-04 | Buy |
4-Methoxy-2-methylphenylboronic acid Chemical Properties, Uses, Production
Uses
4-Methoxy-2-Methylphenylboronic Acid is a useful research chemical.
Chemical Properties
White solid
Uses
suzuki reaction
Uses
Reactant for preparation of biologically active molecule preparation of hydroxyphenylnaphthols as 17-hydroxysteroid dehydrogenase Type 2 inhibitors
Synthesis
5419-55-6
27060-75-9
208399-66-0
4-Methoxy-2-methylphenylboronic acid was synthesized as follows: 4-bromo-3-methylanisole (10 g, 0.050 mol) was used as starting material, and reacted with n-butyllithium (24 mL of 2.5 M hexane solution, 0.055 mol) under anhydrous and anaerobic conditions at a low temperature (-78°C) to generate the corresponding aryl lithium intermediate. Subsequently, triisopropyl borate (57.7 mL, 47.02 g, 0.25 mol) was added to the reaction system, slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the crude product was obtained by acidic hydrolysis treatment and purified to give 5.7 g of 4-methoxy-2-methylphenylboronic acid white solid in 69% yield. The product was characterized by mass spectrometry (ESI), m/z 313 (2M-H2O-H)-.
References
[1] Organic Letters, 2001, vol. 3, # 26, p. 4263 - 4265
[2] Patent: US2003/181519, 2003, A1
4-Methoxy-2-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD | 19963477321; 19963477321 | 2041275825@qq.com | China | 1541 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Latest Price from 4-Methoxy-2-methylphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 4-METHOXY-2-METHYLPHENYLBORONIC ACID
208399-66-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | 4-METHOXY-2-METHYLPHENYLBORONIC ACID
208399-66-0
|
$1.00 | 1KG | 97%-99% | 1kg;5kg;100kg | Career Henan Chemical Co |
-
- 4-METHOXY-2-METHYLPHENYLBORONIC ACID
208399-66-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-METHOXY-2-METHYLPHENYLBORONIC ACID
208399-66-0
- $1.00
- 97%-99%
- Career Henan Chemical Co
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