6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
- CAS No.
- 91523-50-1
- Chemical Name:
- 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
- Synonyms
- 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carbox;6-Hydroxy-1,2,3,4-tetrahydro-sioquinoline-1-carboxylicacid;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-caeboxylic acid;6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID;1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6-hydroxy-;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxcarboxylicacid;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid, CAS 91523-50-1;6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-16-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid-carboxylic acid
- CBNumber:
- CB2353663
- Molecular Formula:
- C10H11NO3
- Molecular Weight:
- 193.2
- MDL Number:
- MFCD04114842
- MOL File:
- 91523-50-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 62452 | 6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID 97% | 91523-50-1 | 0.25G | $99 | 2026-04-30 | Buy |
| AstaTech | 62452 | 6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID 97% | 91523-50-1 | 1G | $188 | 2026-04-30 | Buy |
| AstaTech | 62452 | 6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID 97% | 91523-50-1 | 5G | $678 | 2026-04-30 | Buy |
| Synthonix | H52597 | 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 97% | 91523-50-1 | 250mg | $60 | 2026-05-06 | Buy |
| Synthonix | H52597 | 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 97% | 91523-50-1 | 1g | $120 | 2026-05-06 | Buy |
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Chemical Properties,Uses,Production
Uses
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic Acid is useful chemical in the studying of proline containing peptides as caspase-2 inhibitors.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 27, p. 1321, 1984 DOI: 10.1021/jm00376a017
Synthesis
588-05-6
298-12-4
91523-50-1
GENERAL PROCEDURE: A solution of 2-oxoacetic acid monohydrate (2.0 g, 22 mmol) in ethanol (10 mL) was added slowly and dropwise to a denatured ethanol (70 mL) solution of 3-hydroxyphenylethylamine hydrochloride (3.08 g, 22.5 mmol) at 4 °C. Immediately after the dropwise addition, a white precipitate was observed to be generated. The ice bath was removed and the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the white solid product 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (3.1 g, 73% yield) was collected by filtration. The product was analyzed by LC/MS (electrospray, positive ion mode) and showed m/z 194 ([M+H]+).
References
[1] Journal of Medicinal Chemistry, 1984, vol. 27, # 10, p. 1321 - 1325
[2] Patent: US6649606, 2003, B1. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 47 - 50
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 7, p. 1799 - 1802
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | zwchem@163.com | China | 529 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4545 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| AN PharmaTech Co Ltd | 86(21)68097365 | sales@anpharma.net | China | 4875 | 55 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3698 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
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