Domoic acid
- CAS No.
- 14277-97-5
- Chemical Name:
- Domoic acid
- Synonyms
- C13732;Domoic;omoicaci;NSC 288031;Domoic acid;L-Domic acid;(-)-Domic acid;DoMoic Acid-d3;(-)-DoMoic Acid-d3;Domoic acid, 100ppm
- CBNumber:
- CB2359498
- Molecular Formula:
- C15H21NO6
- Molecular Weight:
- 311.33
- MDL Number:
- MFCD06795841
- MOL File:
- 14277-97-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 213-217℃ |
|---|---|
| Boiling point | 451.38°C (rough estimate) |
| Density | 1.1800 (rough estimate) |
| refractive index | 1.5130 (estimate) |
| storage temp. | -20°C |
| solubility | methanol: 0.6 mg/mL |
| form | solid |
| pka | 2.08±0.60(Predicted) |
| color | white |
| optical activity | -109.612 (H2O) |
| Water Solubility | Soluble in water at 8mg/ml. Soluble in methanol at 0.6mg/ml. |
| Merck | 13,3451 |
| BRN | 46376 |
| Stability | Light Sensitive |
| InChIKey | VZFRNCSOCOPNDB-AOKDLOFSSA-N |
| SMILES | OC([C@H](C)/C=C/C=C([C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1)/C)=O |
| FDA UNII | M02525818H |
| EPA Substance Registry System | Domoic acid (14277-97-5) |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H370 |
| Precautionary statements | P260-P264-P270-P301+P312-P308+P311-P405 |
| target organs | Central nervous system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
| RTECS | UX9665100 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Oral STOT SE 1 |
| Hazardous Substances Data | 14277-97-5(Hazardous Substances Data) |
| Toxicity | An excitory amino acid isolated from the red alga Chondria armata. A structural analog of kainic acid and domoic acid has been shown to be responsible for the shellfish poisoning associated with eating certain cultured blue mussels. |
Domoic acid price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D6152 | Domoic acid ≥90% (HPLC) | 14277-97-5 | 1mg | $234 | 2023-01-07 | Buy |
| Sigma-Aldrich | D6152 | Domoic acid ≥90% (HPLC) | 14277-97-5 | 5mg | $772 | 2023-01-07 | Buy |
| Cayman Chemical | 21433 | Domoic Acid ≥98% | 14277-97-5 | 50μg | $255 | 2026-04-30 | Buy |
| Cayman Chemical | 21433 | Domoic Acid ≥98% | 14277-97-5 | 500μg | $99 | 2021-12-16 | Buy |
| Cayman Chemical | 21433 | Domoic Acid ≥98% | 14277-97-5 | 1mg | $158 | 2021-12-16 | Buy |
Domoic acid Chemical Properties, Uses, Production
Chemical Properties
Off-White Solid
Uses
Labelled Domoic Acid. Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning ass ociated with ingestion of certain cultured blue mussels. Domoic Acid is a structural analog of Kainic acid (K135000).
Uses
Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning associated with ingestion of certain cultured blue mussels. Domoic acid is a structural analog of Kainic acid (K135000). DA. EU regulated marine toxin.
Uses
Domoic acid has been used:
- as an excitatory neurotoxin to determine brain transcriptional response
- to study its cytotoxic, genotoxic and immunotoxic effects on the marine mussel M. edulis
- to study its neurobehavioral effects on mouse fetuses
Definition
ChEBI: A L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is an analog of kainic acid and is the neurotoxin associated with the a nesic shellfish poisoning (ASP).
General Description
Domoic acid, a heterocyclic amino acid neurotoxin is synthesized by various marine algaes. It possess some structural similarity to kainic acid.
Biological Activity
More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.
Biochem/physiol Actions
Domoic acid is a potent agonist at receptors for excitatory amino acids glutamate and kainate. It has highest affinity for AMPA/kainate receptor of any kainate agonist. It can causes excessive excitation of neurons leading to depletion of energy stores.
Synthesis
A method using marine diatom symbiotic bacteria fermentation:
1) Strain activation.
2) Seed culture preparation: medium sterilization, inoculation, and aerobic cultivation.
3) Fermentation: inoculating the seed culture into fermentation medium under similar conditions for 48-52h.
4) Extraction: filtering the broth, extracting the biomass with methanol three times, combining and concentrating the extracts.
5) Purification: eluting the crude extract, collecting the target fraction, and evaporating to obtain a white powder.
Purification Methods
Domoic acid (~300 mg) is purifed on a Dowex1 column (3.5 x 40 mm, 200-400 mesh, acetate form), washed with H2O until neutral, then eluted with increasing concentrations of AcOH (8L) from 0 to 0.25M. The fraction containing domoic acid (in 50mL) is collected, evaporated to dryness under reduced pressure and recrystallised from aqueous EtOH. It is a glutamate and a Kainate receptor agonist. [Impellizzeri et al. Phytochemistry 14 1549 1975, Takemoto & Diago Arch Pharm 293 627 1960, Beilstein 22/4 V 371.]
Domoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
View Latest Price from Domoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | DOMOIC ACID
14277-97-5
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-11 | Domoic acid
14277-97-5
|
10g | TargetMol Chemicals Inc. |
-
- DOMOIC ACID
14277-97-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Domoic acid
14277-97-5
- $0.00
- TargetMol Chemicals Inc.
