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H-Pro-nhet HCl

H-Pro-nhet HCl Structure
H-Pro-nhet HCl structure
CAS No.
58107-62-3
Chemical Name:
H-Pro-nhet HCl
Synonyms
H-Pro-NHEt;L-Pro-NHET.HCL;H-Pro-nhet HCl;H-L-Pro-NHEtHCl;PROLINE-NHET HCL;H-PRO-NHET HCL USP/EP/BP;H-Pro-NHEt hydrochloride;L-PROLINE ETHYLAMIDE HYDROCHLORIDE;L-Proline ethylamide hydrochloride98%;(S)-N-Ethyl-2-pyrrolidinecarboxamide HCl
CBNumber:
CB2359690
Molecular Formula:
C7H15ClN2O
Molecular Weight:
178.66
MDL Number:
MFCD00238159
MOL File:
58107-62-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:38
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H-Pro-nhet HCl Properties

storage temp. Inert atmosphere,Room Temperature
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

HS Code  2933998090

H-Pro-nhet HCl price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 287817 L-Proline ethylamide hydrochloride Asreported 58107-62-3 250mg $336 2026-06-03 Buy
Usbiological 287817 L-Proline ethylamide hydrochloride Asreported 58107-62-3 500mg $460 2026-06-03 Buy
Usbiological 287817 L-Proline ethylamide hydrochloride Asreported 58107-62-3 1g $705 2026-06-03 Buy
Usbiological 287817 L-Proline ethylamide hydrochloride Asreported 58107-62-3 2g $965 2026-06-03 Buy
Usbiological 287817 L-Proline ethylamide hydrochloride Asreported 58107-62-3 5g $1340 2026-06-03 Buy
Product number Packaging Price Buy
287817 250mg $336 Buy
287817 500mg $460 Buy
287817 1g $705 Buy
287817 2g $965 Buy
287817 5g $1340 Buy

H-Pro-nhet HCl Chemical Properties,Uses,Production

Synthesis

Ethylamine

75-04-7

L-Proline

147-85-3

H-PRO-NHET HCL

58107-62-3

Dimethyldichlorosilane (148.4 g, 1.15 mol) was slowly added dropwise to an anhydrous pyridine (500 ml) suspension of L-proline (115.1 g, 1.00 mol) at 0 °C and under argon protection. The reaction mixture was stirred at 0 °C for 2 h. After that, dry ethylamine (180.3 g, 4.00 mol) was added at the same temperature. Subsequently, the reaction mixture was transferred to room temperature and continued stirring for 1 hour. The precipitate was separated from the solution by filtration and the solvent was removed under reduced pressure. The resulting viscous residue was dissolved in 5% sodium carbonate solution (300 ml) and the aqueous layer was subsequently washed with ether-hexane (1:1, 400 ml). The aqueous phase was concentrated under reduced pressure and 17% hydrochloric acid (200 ml) was added to the crude product, L-proline acetamide, and again evaporated under reduced pressure. Methanol (400 ml) was added to the residue and the solvent was removed under reduced pressure after filtration to remove inorganic salts. After addition of ether (500 ml) and stirring for 1 hr, pure (S)-N-ethylpyrrolidine-2-carboxamide hydrochloride was isolated from the solution by filtration. The yield was 148.4 g (83.1% yield) as white crystals with a melting point of 98-100 °C (literature value 97 °C).HPLC purity 99.24%. Specific optical rotation [α]D27 -52.48 (c 0.3, water).IR spectrum (cm-1): 3509, 3453, 2971, 2927, 2593, 2471, 1686, 1577, 1471, 1396, 1290, 1259, 1147, 1055, 816, 565.1H NMR (δ, ppm, J/Hz ): 1.16 (3H, t, J=7.2, CH2CH3); 1.96-2.11 (3H, m, 3-CHA, 4-CH2); 2.50-2.64 (1H, m, 3-CHB); 3.19-3.35 (2H, m, 5-CH2); 3.43-3.52 (2H, m, CH2CH3); 4.62-4.71 (1H, m, 2-CH); 7.89 (1H, br.s, N+H); 10.46 (1H, br.s, N+H); 8.68 (1H, t, J=7.1, CONH).13C NMR (δ, ppm): 12.9; 23.3; 29.2; 34.3; 46.1; 59.4; 168.4.Mass spectra (m/z. Irel%): 143 [M-Cl]+ (100). Elemental analysis measured values (%): C 47.13; H 8.55; N 15.81. C7H15ClN2O calculated values (%): C 47.06; H 8.46; N 15.68.

References

[1] Chemistry of Heterocyclic Compounds, 2014, vol. 50, # 2, p. 287 - 289
[2] Khim. Geterotsikl. Soedin., 2014, vol. 50, # 2, p. 315 - 317,3

H-Pro-nhet HCl Preparation Products And Raw materials

Raw materials

Ethylamine L-Proline Hydrochloric acid

Preparation Products

H-Pro-nhet HCl Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
Shanghai Synteam Biochem CO.,ltd +86-021-58380978 13482386415 info@systeambc.com China 897 50
Shanghai GL Peptide Ltd. +86-21-61263310 13764994101 fisherwang@glschina.com China 8058 55
Shanghai QianYan Bio-technology Co., Ltd 02781293128 orders@biochemsafebuy.com China 9904 55
Wuxi Asia Peptide Biotechnology Limited Company 0510-83583050 13771062561 willsun@peptide-search.com China 6713 58
Supplier Advantage
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
9ding chemical ( Shanghai) Limited 56
Bide Pharmatech Ltd. 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Shanghai YuLue Chemical Co., Ltd. 55
Shanghai Synteam Biochem CO.,ltd 50
Shanghai GL Peptide Ltd. 55
Shanghai QianYan Bio-technology Co., Ltd 55
Wuxi Asia Peptide Biotechnology Limited Company 58

View Lastest Price from H-Pro-nhet HCl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H-PRO-NHET HCL pictures 2019-07-06 H-PRO-NHET HCL
58107-62-3
 $1.00 1KG 99% 20kg Career Henan Chemical Co

H-Pro-nhet HCl Spectrum

H-PRO-NHET HCL(58107-62-3)1HNMR

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L-PROLINE ETHYLAMIDE HYDROCHLORIDE PROLINE-NHET HCL (S)-N-Ethyl-2-pyrrolidinecarboxamide monohydrochloride L-Pro-NHET.HCL L-Proline ethylamide hydrochloride98% (2S)-N-ethylpyrrolidine-2-carboxamide,hydrochloride H-Pro-NHEt hydrochloride H-PRO-NHET HCL USP/EP/BP (S)-N-Ethylpyrrolidine-2-carboxamide hydrochloride H-L-Pro-NHEtHCl (S)-N-Ethyl-2-pyrrolidinecarboxamide HCl (S)-N-Ethylpyrrolidine-2-carboxamide hydrochloride - [E92146] L-Pro-NHEt.HclL-proline ethylamide hydrochloride H-Pro-NHEt H-Pro-nhet HCl 58107-62-3