L-Prolinamide
- CAS No.
- 7531-52-4
- Chemical Name:
- L-Prolinamide
- Synonyms
- PROLINAMIDE;(S)-pyrrolidine-2-carboxamide;H-PRO-NH2;Pro-Nh2;L-PROLINE AMIDE;L-(-)-PROLINAMIDE;(S)-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE;inamide;L-Pro-NH2;L- prolide
- CBNumber:
- CB4370596
- Molecular Formula:
- C5H10N2O
- Molecular Weight:
- 114.15
- MDL Number:
- MFCD00005253
- MOL File:
- 7531-52-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 95-97 °C (lit.) |
|---|---|
| alpha | -106 º (c=2, EtOH) |
| Boiling point | 213.66°C (rough estimate) |
| Density | 1.1008 (rough estimate) |
| refractive index | 1.4720 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Powder or Granules |
| pka | 16.21±0.20(Predicted) |
| color | White to straw |
| optical activity | [α]20/D 106°, c = 2 in ethanol |
| Water Solubility | Soluble in water and ethanol (50 mg/ml). |
| BRN | 80807 |
| Major Application | peptide synthesis |
| InChI | 1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m0/s1 |
| InChIKey | VLJNHYLEOZPXFW-BYPYZUCNSA-N |
| SMILES | NC(=O)[C@@H]1CCCN1 |
| CAS DataBase Reference | 7531-52-4(CAS DataBase Reference) |
| FDA UNII | VD6PQK9DHG |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
L-Prolinamide price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 287059 | L-Prolinamide 98% | 7531-52-4 | 1g | $28.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 287059 | L-Prolinamide 98% | 7531-52-4 | 5g | $119 | 2026-04-30 | Buy |
| TCI Chemical | P1382 | L-Prolinamide >97.0%(T) | 7531-52-4 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | P1382 | L-Prolinamide >97.0%(T) | 7531-52-4 | 5g | $41 | 2026-04-30 | Buy |
| TRC | TRC-P755975-5G | L-Prolinamide | 7531-52-4 | 5g | $103 | 2026-06-03 | Buy |
L-Prolinamide Chemical Properties, Uses, Production
Synthesis
20% Pd(OH)₂/C (Pearlman catalyst, 80 mg) was added to a solution of the aminoamide adduct (175 mg, 0.8 mmol) in an EtOH/AcOH (1:1) (4 mL) mixture. The mixture was stirred at room temperature under H₂ (1 atm) for 14 hours. The mixture was degassed under an argon flow and filtered through diatomaceous earth. The collected solids were washed with EtOH (3 x 10 mL). The combined filtrate and washes were concentrated. The residue was neutralized with concentrated NH₄OH (2 mL). The mixture was placed in FC (eluent, MeOH/CH₂Cl₂/concentrated NH₄OH 50/50/1) to give L-prolylamide.
Figure 1 Synthetic route of L-Prolinamide
Chemical Properties
Crystalline
Uses
Proline based organocatalyst.
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. Also it is a efficient organocatalysts for aldol reactions on water.
Definition
ChEBI: The carboxamide derivative of L-proline.
reaction suitability
reaction type: solution phase peptide synthesis
L-Prolinamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Bright Pharma Biotechnology Co., Ltd. | 0571-85775770 13575490453 | info@brightpharmabio.com | China | 33 | 58 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
| Anhui Cheer-Our Medical technology Co.,Ltd | 63535381 13485700777 | gaylen@cheer-our.com | China | 101 | 58 |
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | sales@cnsynchem.com | China | 55 | 65 |
| Organic Bio-Tech (Suzhou) Co.,Ltd | 18061997750 | info@organic-Biotechnology.com | China | 192 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
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- Apr 16,2025
View Latest Price from L-Prolinamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | L-Prolinamide
7531-52-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-17 | L-Prolinamide
7531-52-4
|
1KG | 98%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | L-Prolinamide
7531-52-4
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- L-Prolinamide
7531-52-4
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- L-Prolinamide
7531-52-4
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- L-Prolinamide
7531-52-4
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
