AFMK
- CAS No.
- 52450-38-1
- Chemical Name:
- AFMK
- Synonyms
- Formyl-N-acetyl-5-methoxykynurenamine;N-γ-Acetyl-N-2-formyl-5-methoxykynurenamine;AFMK;NSC 688263;AFMK, 10 mM in DMSO;Melatonin Impurtiy 5;Melatonin Impurity 20;Acetyl-N-formyl-5-methoxykynurenamine;N1-Acetyl-N2-forMyl-5-MethoxykynuraMine;N-acetyl-N-formyl-5-methoxykynurenamine
- CBNumber:
- CB2366733
- Molecular Formula:
- C13H16N2O4
- Molecular Weight:
- 264.28
- MDL Number:
- MFCD02683241
- MOL File:
- 52450-38-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 138-140°C |
|---|---|
| Boiling point | 589.4±50.0 °C(Predicted) |
| Density | 1.216±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| pka | 13.79±0.70(Predicted) |
| color | white |
| InChI | 1S/C13H16N2O4/c1-9(17)14-6-5-13(18)11-7-10(19-2)3-4-12(11)15-8-16/h3-4,7-8H,5-6H2,1-2H3,(H,14,17)(H,15,16) |
| InChIKey | JYWNYMJKURVPFH-UHFFFAOYSA-N |
| SMILES | COc1ccc(NC=O)c(c1)C(=O)CCNC(C)=O |
| FDA UNII | S82P8JZ4YJ |
| UNSPSC Code | 12352116 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
AFMK price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB01335 | N1-Acetyl-N2-formyl-5-methoxykynuramine ≥95% (HPLC) | 52450-38-1 | 5mg | $101 | 2026-04-30 | Buy |
| Sigma-Aldrich | SMB01335 | N1-Acetyl-N2-formyl-5-methoxykynuramine ≥95% (HPLC) | 52450-38-1 | 25mg | $403 | 2026-04-30 | Buy |
| Cayman Chemical | 10005254 | AFMK ≥98% | 52450-38-1 | 1mg | $26 | 2026-04-30 | Buy |
| Cayman Chemical | 10005254 | AFMK ≥98% | 52450-38-1 | 5mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 10005254 | AFMK ≥98% | 52450-38-1 | 10mg | $147 | 2026-04-30 | Buy |
AFMK Chemical Properties,Uses,Production
Description
Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans. AFMK is a melatonin metabolite first identified in rat brain. AFMK has antioxidant and free radical scavenging activities in several experimental models. AFMK may also be measured in plasma as an index of melatonin synthesis and metabolism.
Chemical Properties
Light Brown Solid
Uses
A metabolite of melatonin (M215000).
Definition
ChEBI: N-gamma-Acetyl-N-2-Formyl-5-Methoxykynurenamine is an aromatic ketone.
in vivo
AFMK is a potent antioxidant in vivo. AFMK significantly reverses radiation-induced decline in the total antioxidant capacity of plasma in mice[2].
| Animal Model: | Male C57BL mice 8 wk of age[2] |
| Dosage: | 10 mg/kg body weight |
| Administration: | Intraperitoneal injection |
| Result: | Radiation-induced decline in the total antioxidant capacity of plasma was significantly reversed in AFMK pretreated mice. AFMK-pretreated irradiated groups showed a significantly lower value of comet tail length and % DNA in tail. |
IC 50
Human Endogenous Metabolite
References
[1] F. HIRATA. In vitro and in vivo formation of two new metabolites of melatonin.[J]. The Journal of Biological Chemistry, 1974, 3 1: 1311-1313. DOI: 10.1016/s0021-9258(19)42976-1
[2] DUN-XIAN TAN. N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant[J]. FASEB Journal, 2001, 15 12: 1-16. DOI: 10.1096/fj.01-0309fje
[3] CATHERINE HARTHé . Radioimmunoassay of N-acetyl-N-formyl-5-methoxykynuramine (AFMK): a melatonin oxidative metabolite[J]. Life sciences, 2003, 73 12: Pages 1587-1597. DOI: 10.1016/s0024-3205(03)00483-1
AFMK Preparation Products And Raw materials
AFMK Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
