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(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol

(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol Structure
(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol structure
CAS No.
62855-02-1
Chemical Name:
(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol
Synonyms
H-D-Tic-ol;(R)-1,2,3,4-Tetrahydroisoquinolyl-methan-3-ol;(R)-1,2,3,4-Tetrahydroisoquinoline-3-methanol;(R)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol;(R)-1,2,3,4-tetrahydroisoquinolin-4-ylmethanol;(3R)-1,2,3,4-tetrahydroisoquinolin-4-ylMethanol;(3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol;(R)-(1,2,3,4-tetrahydroisoduinolin-3-yl)-Methanol;(R)-(+)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol;3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (R)-
CBNumber:
CB2380641
Molecular Formula:
C10H13NO
Molecular Weight:
163.22
MDL Number:
MFCD02684327
MOL File:
62855-02-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:17
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(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol Properties

Boiling point 307.9±27.0 °C(Predicted)
Density 1.081±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 14.57±0.10(Predicted)
form Crystalline
color White
optical activity 101.4°(C=0.01 g/ CHCL3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Safety Statements  24/25
HS Code  29339900

(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 463620 (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 100mg $418 2026-06-03 Buy
Usbiological 463620 (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 500mg $1027 2026-06-03 Buy
Apolloscientific OR451146 (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 98% 62855-02-1 250mg $21 2026-06-04 Buy
Apolloscientific OR451146 (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 98% 62855-02-1 1g $24 2026-06-04 Buy
Apolloscientific OR451146 (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 98% 62855-02-1 5g $107 2026-06-04 Buy
Product number Packaging Price Buy
463620 100mg $418 Buy
463620 500mg $1027 Buy
OR451146 250mg $21 Buy
OR451146 1g $24 Buy
OR451146 5g $107 Buy

(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol Chemical Properties, Uses, Production

Chemical Properties

White crystal

Uses

(3R)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol is used in asymmetric synthesis of vinylmorpholines by palladium-catalyzed tandem allylic substitutions with amino alcohols.

Synthesis

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

79815-19-3

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

18881-17-9

GENERAL STEPS: This experimental procedure was modified with reference to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether: ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (4) as a yellow crystalline solid in a yield of 2.09 g (98% yield, melting point 95-97 °C). The spinor data were in agreement with those reported in the literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0, 47.83, 30.9. 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol Preparation Products And Raw materials

Raw materials

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester H-DL-Tic-OH Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol Suppliers

Global Suppliers ( 107)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Wuhan Fortuna Chemical Co., Ltd 027-59207852 13308628970 buy@fortunachem.com China 2681 58
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Shanghai Litong Chemical Technology Co.,Ltd. 13598610367 0373-7129549 2468833170@qq.com China 932 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
Shanghai Witofly Chemical Co.,Ltd sales@witofly.com China 2853 52
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Wuhan Fortuna Chemical Co., Ltd 58
T&W GROUP 58
Shanghai Litong Chemical Technology Co.,Ltd. 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Shanghai Witofly Chemical Co.,Ltd 52

View Latest Price from (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol pictures 2026-08-25 (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
62855-02-1
 $1.10-9.90 1KG 99%min 100KG ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL pictures 2020-01-13 (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
62855-02-1
 $3.00 1KG 98% 200KG Career Henan Chemical Co

(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol Spectrum

(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL(62855-02-1)1HNMR

62855-02-1 ((R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol) Related Search:

D-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Boc-7-hydroxy-D-Tic-OH N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid narciclasine
(S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol Fmoc-7-hydroxy-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid H-D-Tic-OtBu HCl (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid t-butyl ester
D-Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid methyl ester D-2-Boc-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol saframycin Mx1
Z-D-Tic-OH Boc-D-Tic-OH D-2-Boc-7-(fluoro)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

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(R)-(+)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol 3(R)-HYDROXYMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE (R)-1,2,3,4-Tetrahydroisoquinolyl-methan-3-ol (3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol 2-chloro-4-[[2-(diethylamino)-5-methoxyphenyl]methyl]-N,N-dimethylaniline (3R)-1,2,3,4-tetrahydroisoquinolin-4-ylMethanol (R)-(1,2,3,4-tetrahydroisoduinolin-3-yl)-Methanol (R)-3-Hydroxymethyl-1, 2, 3, 4-tetrahydroisoquinoline (R)-1,2,3,4-tetrahydroisoquinolin-4-ylmethanol (R)-1,2,3,4-Tetrahydroisoquinolylmethan-3-ol, >=98% (R)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol (R)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol,99%e.e. 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (R)- 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3R)- (R)-1,2,3,4-Tetrahydroisoquinoline-3-methanol (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL USP/EP/BP H-D-Tic-ol 3-isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3R), 98%min (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)-methanol 62855-02-1 62855-02-2