D-Aspartic acid dimethyl ester hydrochloride
- CAS No.
- 69630-50-8
- Chemical Name:
- D-Aspartic acid dimethyl ester hydrochloride
- Synonyms
- H-D-Asp(OMe)-OH;(R)-DimethyL;D-Asp(OMe)-OMe·HCl;H-D-ASP(ME)-OME HCL;H-D-ASP(OME)-OME HCL;D-ASPARTIC ACID DIME;2-aminosuccinate hydrochL;D-ASPARTIC ACID(OME)-OME HCL;H-D-Asp(Me)-OMe hydrochloride;dimethyl (2R)-2-aminobutanedioate
- CBNumber:
- CB2397092
- Molecular Formula:
- C6H12ClNO4
- Molecular Weight:
- 197.62
- MDL Number:
- MFCD00070384
- MOL File:
- 69630-50-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 114-119℃ |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | Off-White |
| optical activity | Consistent with structure |
| InChI | InChI=1/C6H11NO4.ClH/c1-10-5(8)3-4(7)6(9)11-2;/h4H,3,7H2,1-2H3;1H/t4-;/s3 |
| InChIKey | PNLXWGDXZOYUKB-NDILARRWNA-N |
| SMILES | [C@H](N)(C(=O)OC)CC(=O)OC.Cl |&1:0,r| |
| CAS DataBase Reference | 69630-50-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H314-H332 | |||||||||
| Precautionary statements | P260-P261-P264-P270-P271-P280-P301+P312-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P321-P322-P330-P363-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
D-Aspartic acid dimethyl ester hydrochloride price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 445513 | D-Aspartic Acid Dimethyl Ester Hydrochloride | 69630-50-8 | 1g | $347 | 2026-06-03 | Buy |
| Usbiological | 445513 | D-Aspartic Acid Dimethyl Ester Hydrochloride | 69630-50-8 | 5g | $573 | 2026-06-03 | Buy |
| Usbiological | 260240 | D-Aspartic acid dimethyl ester hydrochloride Asreported | 69630-50-8 | 1g | $350 | 2026-06-03 | Buy |
| Usbiological | 260240 | D-Aspartic acid dimethyl ester hydrochloride Asreported | 69630-50-8 | 2g | $483 | 2026-06-03 | Buy |
| Usbiological | 260240 | D-Aspartic acid dimethyl ester hydrochloride Asreported | 69630-50-8 | 5g | $652 | 2026-06-03 | Buy |
D-Aspartic acid dimethyl ester hydrochloride Chemical Properties, Uses, Production
Chemical Properties
White to off-white powder
Uses
D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.
Synthesis
67-56-1
1783-96-6
14358-33-9
106.8 g (0.8 mol) of D-aspartic acid and 700 ml of methanol were added to the reaction vessel and 84.4 ml (1.2 mol) of thionyl chloride was added slowly dropwise under stirring, controlling the reaction temperature to 0°C. After the dropwise addition, the reaction system was warmed up to room temperature (about 29°C) and the reaction was continued with stirring for 30 hours. Upon completion of the reaction, excess methanol and thionyl chloride were removed from the reaction solution by distillation. The remaining oily material was dissolved in 3.5 times the volume of ether for crystallization to obtain white crystals. After filtration, the crystals were washed with ether three times and dried to finally obtain 107.8 g of white solid DL-aspartic acid dimethyl ester hydrochloride.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10460 - 10474
[2] Journal of Organic Chemistry, 2012, vol. 77, # 5, p. 2299 - 2309
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 2936 - 2947
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 24, p. 7215 - 7226
[5] Patent: WO2010/31184, 2010, A1. Location in patent: Page/Page column 22
D-Aspartic acid dimethyl ester hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| YangZhou Ruihong Biotech Co., Ltd. | 0514-015380367604 15380367604 | sales@ruibobiotech.com | China | 509 | 55 |
| Nanjing Danron Bio-New Materials Co.Ltd | 18936428028 18936428028 | 3806853067@qq.com | China | 147 | 58 |
| Wuxi Likang Biopharmaceutical Technology Co., Ltd | 15250805028 | 649163353@qq.com | China | 244 | 58 |
| Wuxi Lihengsheng Biopharmaceutical Technology Co., Ltd | 15250805028 15250805028 | 649163353@qq.com | China | 8000 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from D-Aspartic acid dimethyl ester hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | D-Asp(ome)-ome.HCl
69630-50-8
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2020-01-13 | D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE
69630-50-8
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- D-Asp(ome)-ome.HCl
69630-50-8
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE
69630-50-8
- $3.00
- 98%
- Career Henan Chemical Co
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