Hydrocortisone sodium phosphate
- CAS No.
- 6000-74-4
- Chemical Name:
- Hydrocortisone sodium phosphate
- Synonyms
- Hydrocortisone 21-disodium phosphate;Cortisol, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI);Coriphate;Efcortesol;Physiocortison;Hydrocortone phosphate;CORTISOL SODIUM PHOSPHATE;Sodium cortisol 21-phosphate;Hydrocortisone 21-disodium salt;Hydrocortisone phosphate sodium
- CBNumber:
- CB2397209
- Molecular Formula:
- C21H29O8P.2Na
- Molecular Weight:
- 486.41
- MDL Number:
- MFCD00152562
- MOL File:
- 6000-74-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| alpha | D25 +120° (H2O) |
|---|---|
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChIKey | RYJIRNNXCHOUTQ-MBXDADQLNA-L |
| SMILES | [C@]12(C)C[C@@H]([C@]3([H])[C@@]4(C)CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@]2(O)C(=O)COP([O-])([O-])=O)O.[Na+].[Na+] |&1:0,3,4,6,16,18,22,r| |
| CAS DataBase Reference | 6000-74-4(CAS DataBase Reference) |
| FDA UNII | 0388G963HY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H312-H332-H361 |
| Precautionary statements | P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
Hydrocortisone sodium phosphate price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BP188 | Hydrocortisone sodium phosphate British Pharmacopoeia (BP) Reference Standard | 6000-74-4 | 100 mg | $303 | 2026-04-30 | Buy |
| Usbiological | 279756 | Hydrocortisone sodium phosphate Asreported | 6000-74-4 | 10mg | $376 | 2026-06-03 | Buy |
| Usbiological | 279756 | Hydrocortisone sodium phosphate Asreported | 6000-74-4 | 25mg | $525 | 2026-06-03 | Buy |
| Usbiological | 279756 | Hydrocortisone sodium phosphate Asreported | 6000-74-4 | 50mg | $718 | 2026-06-03 | Buy |
| Usbiological | 279756 | Hydrocortisone sodium phosphate Asreported | 6000-74-4 | 100mg | $987 | 2026-06-03 | Buy |
Hydrocortisone sodium phosphate Chemical Properties, Uses, Production
Originator
Corphos,Tilden Yates,US,1959
Uses
Hydrocortisone Sodium Phosphate is the sodium phosphate salt of the corticosteroid Hydrocortisone (H714615).
Definition
ChEBI: An organic sodium salt that is the disodium salt of cortisol phosphate.
Manufacturing Process
21-iodo-11β:17α-dihydroxypregn-4-ene-3,20-dione (5.0 g) in pure acetonitrile
(125 ml) was mixed with a solution of 90% phosphoric acid (2.5 ml) and
triethylamine (7.5 ml) in acetonitrile (125 ml) and boiled under reflux for 4
hours. The solvent was removed in vacuo and the residue, dissolved in
ethanol (20 ml) and water (80 ml), was passed down a column of Zeo-Karb
225 (H+form) (60 g) made up in 20% alcohol. Elution was continued with
20% alcohol (50 ml), 50% alcohol (50 ml) and alcohol (150 ml). The eluate
was at first cloudy, but by the end of the elution it was clear and nonacid.
The eluate was titrated to pH 7 with 0.972N NaOH (63 ml). Removal of
solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes.
The solid insoluble inorganic phosphate was filtered off and washed with
methanol (200 ml). The slightly cloudy filtrate was filtered again, and
evaporated to dryness in vacuo. The residual gum dissolved readily in water
(40 ml) and on addition of acetone (600 ml) to the solution a mixture of
sodium salts of hydrocortisone 21-phosphate separated as a white solid. This
was collected after 2 days, washed with acetone and dried at 100°C/0.l mm/2
hr to constant weight. Yield 4.45 g.
brand name
Hydrocortone (Merck).
Therapeutic Function
Glucocorticoid
Hydrocortisone sodium phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Chenxin Pharmaceutical Co., Ltd. | 18696113233 | like1076463918@163.com | China | 3117 | 58 |
| Nanjing Steyr Pharmaceutical Technology Co., Ltd | 025-86711996 18351956221 | caigou@pharmtec.cn | China | 66 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Xunteng International Trading Co.,Limited | China Hong Kong | 876 | 55 | ||
| Hubei XinyuanShun Chemical Co., Ltd. | 13971561712, 13995564702, 027-50664929 | hbeixys2001@163.com | China | 3110 | 55 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17968 | 58 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 1983 | 58 |
View Latest Price from Hydrocortisone sodium phosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Hydrocortisone phosphate sodium
6000-74-4
|
$98.00-233.00 | 99.40% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | Hydrocortisone Sodium Phosphate
6000-74-4
|
$8.00 | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2021-07-02 | Hydrocortisone sodium phosphate
6000-74-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Hydrocortisone phosphate sodium
6000-74-4
- $98.00-233.00
- 99.40%
- TargetMol Chemicals Inc.
-
- Hydrocortisone Sodium Phosphate
6000-74-4
- $8.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Hydrocortisone sodium phosphate
6000-74-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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