Hydrocortisone
- CAS No.
- 50-23-7
- Chemical Name:
- Hydrocortisone
- Synonyms
- CORTISOL;HYDROCORTISONE BASE;HC;HYDROCORTISONEACETATE;Hydrocortisone - CAS 50-23-7 - Calbiochem;Hytone;H-Cort;Cortril;Epicort;Penecort
- CBNumber:
- CB9756715
- Molecular Formula:
- C21H30O5
- Molecular Weight:
- 362.47
- MDL Number:
- MFCD00011654
- MOL File:
- 50-23-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 211-214 °C(lit.) |
|---|---|
| alpha | 166 º (c=1, C2H5OH 25 ºC) |
| Boiling point | 414.06°C (rough estimate) |
| Density | 1.0812 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| Flash point | 220°C |
| storage temp. | -20°C |
| solubility | H2O: 100 mg/mL |
| form | powder |
| color | White |
| PH | 5.0- 7.0 |
| biological source | non-animal source |
| Water Solubility | 319.7mg/L(25 ºC) |
| Decomposition | 220 ºC |
| Merck | 14,4787 |
| BRN | 1354819 |
| Henry's Law Constant | 1.7×102 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| Major Application |
clinical testing clinical testing |
| InChIKey | JYGXADMDTFJGBT-VWUMJDOOSA-N |
| SMILES | C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23 |
| LogP | 1.610 |
| CAS DataBase Reference | 50-23-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | cortisol; hydrocortisone |
| FDA UNII | WI4X0X7BPJ |
| NCI Drug Dictionary | Aeroseb-HC |
| ATC code | A01AC03,A07EA02,C05AA01,D07AA02,D07XA01,H02AB09,R01AD60,S01BA02,S01CB03,S02BA01 |
| NIST Chemistry Reference | Hydrocortisone(50-23-7) |
| EPA Substance Registry System | Hydrocortisone (50-23-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360Df-H373 | |||||||||
| Precautionary statements | P202-P260-P280-P308+P313-P405-P501 | |||||||||
| target organs | Eyes,Central nervous system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 62-63 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GM8925000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29372100 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
|||||||||
| Hazardous Substances Data | 50-23-7(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 subcutaneous in mouse: > 500mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Hydrocortisone price More Price(105)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001092 | Hydrocortisone for peak identification European Pharmacopoeia (EP) Reference Standard | 50-23-7 | 5 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | NIST921A | Cortisol (Hydrocortisone) NIST?SRM? | 50-23-7 | 1G | $2990 | 2026-04-30 | Buy |
| Sigma-Aldrich | H1300000 | Hydrocortisone European Pharmacopoeia (EP) Reference Standard | 50-23-7 | 70 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | H0396 | Hydrocortisone-Water Soluble BioReagent, suitable for cell culture | 100MG | $144 | 2026-04-30 | Buy | |
| Sigma-Aldrich | C-106 | Cortisol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 50-23-7 | 1mL | $113 | 2026-04-30 | Buy |
Hydrocortisone Chemical Properties, Uses, Production
Chemical Properties
crystalline white powder
Originator
Hydrocortone,MSD,US,1952
Uses
Principle glucocorticoid hormone produced by adrenal cortex. An anti-inflammatory hormone.
Uses
glucocorticoid, antiinflammatory
Uses
Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
Definition
ChEBI: A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immun responses
Indications
Hydrocortisone (Cortizone, Cortaid, Anusol-HC, Hytone, LactiCare-HC, Sarnol HC, Penecort, Texacort, and many other branded products) may be purchased as a generic drug.
Manufacturing Process
The following example from US Patent 2,602,769 illustrates the preparation of
17-hydroxycorticosterone (compound F) from 11-desoxy-17-
hydroxycorticosterone (compound S). A medium was prepared from 0.5%
peptone, 2% dextrose, 0.5% soybean meal, 0.5% KH2PO4, 0.5% sodium
chloride and 0.3% yeast extract in tap water. To 200 ml of this sterilized
medium was added an inoculum of the vegetative mycella of Cunninghamella blakesleeana. The spores had first been transferred from a sport slant to a
broth medium and the broth medium was aerobically incubated at 24°C for 24
to 72 hours in a .reciprocating shaker until the development of vegetative
growth. The inoculated medium containing added vegetative mycella of
Cunninghamella blakesleeana was incubated for 48 hours at 24°C following
which was added 66 mg of compound S, 11-desoxy-17-hydroxycorticosterone
in solution in a minimum of ethanol, and incubation was maintained for 7
hours at 24°C. The beer containing steroid was diluted with 800 ml of
acetone, shaken 1 hour on a reciprocating shaker and filtered. The cake was
suspended in 500 ml of acetone, shaken another hour and again filtered. The
filtrates were combined and the acetone was volatilized under reduced
pressure at 50°C. Acetone was then added, if necessary, to bring the
concentration to 20% acetone and this resulting aqueous acetone solution was
extracted five times each with one-third volume of Skellysolve B petroleum
ether to remove fatty materials. These extracts were back washed two times
with one-tenth volume of 20% aqueous acetone and the washings were added
to the main acetone extract.
The combined acetone extracts were extracted six times with one-fourth
volume of ethylene dichloride and the ethylene dichloride extract was
evaporated under vacuum to leave the steroid residue. This steroid residue
was taken up in a minimum of methylene chloride and applied to the top of a
column packed with 30 grams of silica which had been previously triturated
with 21 ml of ethylene glycol. Then various developing mixtures, saturated
with ethylene glycol, were passed over the column. Cuts were made as each
steroid was eluted as determined by the lowering of the absorption of light at
240 nm on the automatic chromatographic fraction cutter.
Band Solvent Tube No. (60ml) Crude Solids (mg)
1 Cyclohexane 1-4 11
2 Cyclohexane-methylene chloride 3:1 5-13 6.4 compound S
3 Cyclohexane-methylene chloride 1:1 14-16 3.0
4 Cyclohexane-methylene chloride 2:3 17-23 6.0 compound E
5 Cyclohexane-methylene chloride 1:4 24-38 12.2 compound F
6 Methylene chloride 39-59 4.8
A 7.7 mg portion of band 5 was taken up in a minimum of acetone and
refrigerated until crystals separated. This cold acetone mixture was
centrifuged and the supernatant liquid removed by pipette. To the remaining
crystals, a few drops of ice-cold ether-acetone, three to one mixture, were
added, shaken, recentrifuged and the supernatant wash liquid removed by
pipette. The ether-acetone wash was repeated. The resulting crystals were
dried under vacuum yielding 3.3 mg of pure compound F, 17-
hydroxycorticosterone.
brand name
Acticort (Baker Norton); Ala-Cort (Del Ray); Cetacort (Healthpoint); Colocort (Paddock); Cort- Dome (Bayer); Cortef (Pharmacia & Upjohn); Cortenema (Solvay Pharmaceuticals); Cortril (Pfizer); Dermacort (Monarch); Dermacort (Solvay Pharmaceuticals); Eldecort (Valeant); Epicort (Bluline); Flexicort (Westwood- Squibb); Glycort (Heran); Hi-Cor (C & M); Hydro-Rx (X Gen); Hydrocortone (Merck); Hytone (Dermik); Hytone (Sanofi Aventis); Nutracort (Healthpoint); Penecort (Allergan); Proctocort (Monarch); Stie-Cort (Stiefel); Synacort (Medicis); Texacort (Sirius).
Therapeutic Function
Glucocorticoid
General Description
Hydrocortisone, 11β,17,21-trihydroxypregn-4-ene-3,20-dione, is the primary natural GCin humans. Despite the large number of synthetic GCs, hydrocortisone,its esters, and its salts remain a mainstay ofmodern adrenocortical steroid therapy and the standard forcomparison of all other GCs and MCs . It isused for all the indications mentioned previously.
Health Hazard
Cortisol Increases (1) protein catabolism (excepting liver) gluconeogenesis; (2) carbohydrate anabolism (liver); (3) blood sugar; (4) glucose absorption; (5) brain excitation; (6) spread of infections; (7)urinary glucose and nitrogen; (8) stress tolerance; (9) lactation; (10) water diuresis.
Regulates general adaptation syndrome, water balance, blood pressure, and hormone release.
Decreases (1) fat anabolism; (2) growth rate; (3) inflammation; (4) eosinophils; (5) lymphocytes; (6) antigen sensitivity; (7) respiratory quotient; (8) ketosis; (9) wound healing; (10) skin pigmentation; (11)RBC hemolysis.
Biological Activity
hydrocortisone is a main glucocorticoid secreted by the adrenal cortex.
Contact allergens
Hydrocortisone is the principal glucocorticoid hor- mone produced by the adrenal cortex and is used topi- cally or systemically. It belongs to the allergenic A group. Marker of allergy is tixocortol pivalate.
Biochem/physiol Actions
Product does not compete with ATP.
Mechanism of action
Hydrocortisone exhibits anti-shock, anti-allergy, and anti-inflammatory action. It raises sugar content in the blood, increases potassium secretion, and lowers sodium excretion from the body. It exhibits anti-metabolic action and reduces histamine synthesis in the body.
Clinical Use
Hydrocortisone is endogenous, and it has both glucocorticoid and mineralocorticoid activity. It is the fundamental structure by which the glucocorticoid and mineralocorticoid activities of all other corticosteroids are judged. Functional groups that are essential for both mineralocorticoid and glucocorticoid activity include the pregnane skeleton with an all-trans backbone, the ring A-en-one system (4 -3-one ring A) and the 17β-ketol side chain (C-20-keto-C-21-hydroxy). The glucocorticoid activity is enhanced by the C-11 and C-17 hydroxyl groups. Hydrocortisone can be used to treat severe asthmatic attacks that do not respond to conventional treatment. It is available as various ester forms.
Safety Profile
Poison by
Synthesis
Hydrocortisone, 11|,17|á,21-trihydroxypregn-4-en-3,20-dione (27.1.8), is synthesized in various ways and from various compounds containing a steroid skeleton. According to one of them, hydrocortisone is synthesized from dextropregnenolone. The double bond between C16 and C17 of dextropregnenolone is oxidized using hydrogen peroxide in a base, forming an epoxide 27.1.1. Interacting this with hydrobromic acid opens the epoxide ring, forming 16-bromo-17-hydroxydextropregnenolone (27.1.2). The resulting bromo derivative undergoes debromination by hydrogen using a palladium on carbon catalyst, and then the secondary hydroxyl group undergoes esterification using formic acid in the presence of p-toluenesulfonic acid, giving 3-formyloxy-17-hydroxydextropregnenolone (27.1.3). The resulting 3-formyloxy- 17-hydroxydextropregnenolone undergoes bromination by bromine, which results in bromination of the C4¨CC5 double bond and the methyl group of acetyl moiety, which forms a tribromo derivative 27.1.4. Reacting the product with sodium iodide results in dehalogenation of the resulting vicinal dibromide, during which the double bond is simultaneously shifted into the position between carbon atoms C5 and C6 that gives the bromoketone 27.1.5. This is reacted with potassium acetate and then with acetic anhydride in the presence of p-toluenesulfonic acid, forming a diacetate 27.1.6. Taking into account that unlike acetates, formates are easily oxidized and give exactly the same products as do the corresponding alcohols, the resulting diacetate is oxidized in an Oppenauer oxidation reaction, using aluminum isopropoxide and cyclohexanone as a hydrogen acceptor. During this, isomerization of the double bond into the primary position between C4 and C5 simultaneously takes place, forming a stable, conjugated vinylketone, after which the acetyl protection of both hydroxyl groups is hydrolyzed using potassium hydroxide, giving 17-hydroxy-11-deoxycorticosterone (27.1.7). This undergoes microbiological oxidation at position C1, forming the desired hydrocortisone (27.1.8). Side reactions of microbiological oxidation using the very same microorganisms can cause hydroxylation of steroids in different positions, using easily accessible progesterone as an initial substance.
Veterinary Drugs and Treatments
Because of its rapid effect and relatively high mineralocorticoid effect,
hydrocortisone sodium succinate (Solu-Cortef) is the most
commonly used form of this medication when an acute glucocorticoid/
mineralocorticoid effect is desired (e.g., acute adrenal insufficiency).
Corticosteroids have not been shown beneficial in treating
hypovolemic shock, but low dose glucocorticoids probably reduce
mortality associated with septic shock.
Glucocorticoids have been used in an attempt to treat practically
every malady that afflicts man or animal, but there are three broad
uses and dosage ranges for use of these agents. 1) Replacement of
glucocorticoid activity in patients with adrenal insufficiency, 2)
as an antiinflammatory agent, and 3) as an immunosuppressive.
Among some of the uses for glucocorticoids include treatment of:
endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases
(e.g., rheumatoid arthritis), collagen diseases (e.g., systemic
lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic
diseases (e.g., pemphigus, allergic dermatoses), hematologic
disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias),
neoplasias, nervous system disorders (increased CSF pressure),
GI diseases (e.g., ulcerative colitis exacerbations), and renal
diseases (e.g., nephrotic syndrome). Some glucocorticoids are used
topically in the eye and skin for various conditions or are injected
intra-articularly or intra-lesionally. The above listing is certainly
not complete.
target
TNF-α | IL Receptor | AP-1 | MMP(e.g.TIMP) | NF-kB | IkB | IKK
storage
Store at RT
Purification Methods
Recrystallise hydrocortisone from EtOH or isoPrOH. It is bitter tasting and has UV with max at 242 nm (log 4.20). Its solubility at 25o is: H2O (0.28%), EtOH (1.5%), MeOH (0.62%), Me2CO (0.93%), CHCl3 (0.16%), propylene glycol (1.3%) and Et2O (0.35%). It gives an intense green colour with conc H2SO4. [Wendler et al. J Am Chem Soc 72 5793 1950, Beilstein 8 IV 3422.]
Hydrocortisone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Fuyu Pharmaceutical Technology Co., Ltd | 0571-8535-0733 19357571632 | lin@forupharm.com | China | 14 | 58 |
| Taizhou DongBang Fine Chemical Co. Ltd. | 0523-86235448 15996000437 | 2535251509@qq.com | China | 50 | 55 |
| Jinan Wald Chemical Co., Ltd. | 0531-88773586 13210588999 | 304264064@qq.com | China | 192 | 58 |
| Wuhan Zenuo Biopharmaceutical Technology Co., Ltd | 027-87781970 15172508891 | 1505560767@qq.com | China | 132 | 58 |
| Wuhan Juchengyuan Biotechnology Co., Ltd | 400-027-6007 18062142210 | 804180422@qq.com | China | 145 | 58 |
| Shandong Mingfeng Pharmaceutical and Technology Co. Ltd | 053155551677 15315114555 | 1345456643@qq.com | China | 298 | 58 |
| SHANDONG OCTAGON CHEMICALS LIMITED | 0535-15589503653 15589503653 | 2959135512@qq.com | China | 193 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
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Related Questions
Ask a questionView Latest Price from Hydrocortisone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-13 | Hydrocortisone
50-23-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-10-13 | Hydrocortisone
50-23-7
|
1Kg/Bag | CEP/EP | 20 tons | Sinoway Industrial co., ltd. | ||
 |
2026-09-24 | Hydrocortisone
50-23-7
|
100Gram | USP/EP | 60kg | Hangzhou Hyper Chemicals Limited |
-
- Hydrocortisone
50-23-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Hydrocortisone
50-23-7
- CEP/EP
- Sinoway Industrial co., ltd.
-
- Hydrocortisone
50-23-7
- USP/EP
- Hangzhou Hyper Chemicals Limited
