Trimethylene oxide
- CAS No.
- 503-30-0
- Chemical Name:
- Trimethylene oxide
- Synonyms
- OXETANE;Oxetan;Oxacyclobutane;OXECTANE;Cyclooxabutane;Trimethylenoxid;1,3-EPOXYPROPAN;1,3-EPOXYPROPANE;Trimethylene oxide;Propane, 1,3-epoxy-
- CBNumber:
- CB0744720
- Molecular Formula:
- C3H6O
- Molecular Weight:
- 58.08
- MDL Number:
- MFCD00005167
- MOL File:
- 503-30-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -97°C |
|---|---|
| Boiling point | 50 °C(lit.) |
| Density | 0.893 g/mL at 25 °C(lit.) |
| vapor pressure | 5.09 psi ( 20 °C) |
| refractive index |
n |
| Flash point | −19 °F |
| storage temp. | 2-8°C |
| solubility | 1000g/l |
| form | Liquid |
| color | Clear colorless |
| Odor | agreeable odor |
| explosive limit | 2.4%(V) |
| Water Solubility | Soluble in water. |
| Merck | 14,9715 |
| BRN | 102382 |
| Henry's Law Constant | 4.0×10-1 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| InChI | 1S/C3H6O/c1-2-4-3-1/h1-3H2 |
| InChIKey | AHHWIHXENZJRFG-UHFFFAOYSA-N |
| SMILES | C1COC1 |
| CAS DataBase Reference | 503-30-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | I279Q16FU6 |
| EPA Substance Registry System | Oxetane (503-30-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302+H312+H332 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P304+P340+P312 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | F,Xn | |||||||||
| Risk Statements | 11-20/21/22 | |||||||||
| Safety Statements | 9-16-26-29 | |||||||||
| RIDADR | UN 1993 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | RQ6825000 | |||||||||
| F | 3-10-23 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Flam. Liq. 2 |
|||||||||
| Hazardous Substances Data | 503-30-0(Hazardous Substances Data) | |||||||||
| Toxicity | mmo-sat 3333 mg/plate EMMUEG 11(Suppl 12),1,88 | |||||||||
| NFPA 704 |
|
Trimethylene oxide price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T76201 | Trimethylene oxide 97% | 503-30-0 | 5g | $189 | 2026-04-30 | Buy |
| Sigma-Aldrich | T76201 | Trimethylene oxide 97% | 503-30-0 | 10g | $296 | 2026-04-30 | Buy |
| TCI Chemical | T0473 | Trimethylene Oxide >98.0%(GC) | 503-30-0 | 10mL | $240 | 2026-04-30 | Buy |
| Chem-Impex | 41480 | Trimethylene oxide ≥98%(GC) | 503-30-0 | 5G | $143.62 | 2026-05-19 | Buy |
| Chem-Impex | 41480 | Trimethylene oxide ≥98%(GC) | 503-30-0 | 10G | $277.52 | 2026-05-19 | Buy |
Trimethylene oxide Chemical Properties, Uses, Production
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
Trimethylene oxide useful for the synthesis of 3-substituted propanols by reaction with Grignards or organolithiums in the presence of CuBr.
Definition
ChEBI: A saturated organic heteromonocyclic parent that is a four-membered ring comprising of three carbon atoms and an oxygen atom.
General Description
Clear, colorless liquid with an agreeable aromatic odor.
Air & Water Reactions
Highly flammable. Water soluble.
Reactivity Profile
TRIMETHYLENE OXIDE reacts with Grignard reagents and organolithium compounds. TRIMETHYLENE OXIDE is also incompatible with oxidizing agents and strong acids. . An explosion occurred when propylene oxide was added to epoxy resin. Polymerization was catalyzed by amine accelerator in the resin [Bretherick 1995]. Propylene oxide and sodium hydroxide base-catalyzed the polymerization of the former, causing ignition and explosion of a drum of the crude product. [Combust Sci. Technol., 1983].
Fire Hazard
TRIMETHYLENE OXIDE is flammable.
Safety Profile
Moderately toxic by subcutaneous route. May be narcotic in high concentrations. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
Synthesis
Trimethylene oxide, also known as 1,3-epoxypropane, can be obtained by ring-closing 3-bromo-1-propanol.
Purification Methods
Distil oxetane twice from sodium metal and then fractionate it through a small column at atmospheric pressure, b 47.0-47.2o. It can also be purified by preparative gas chromatography using a 2m silica gel column. Alternatively, add KOH pellets (50g for 100g of oxetane) and distil it through an efficient column or a column packed with 1/4in Berl Saddles with the main portion boiling at 45-50o being collected and redistilled over fused KOH. [Noller Org Synth Coll Vol III 835 1955, Dittmer et al. J Am Chem Soc 79 4431 1957, Beilstein 17 H 6, 17 I 3, 17 II 12, 17 III/IV 13, 17/1 V 11.]
Trimethylene oxide Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Kuokun Biotechnology Co., Ltd | 15900929397 | 3154863169@qq.com | China | 404 | 58 |
| Shanghai Brain Biotechnology Co., Ltd. | 13564638271 | shhjiang1977@163.com | China | 2979 | 55 |
| Shanghai Birch Chemical Technology Co., Ltd. | 021-54096810 18017263450 | sales@birchchem.com | China | 500 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
View Latest Price from Trimethylene oxide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | TRIMETHYLENE OXIDE
503-30-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | oxetane
503-30-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-11-08 | TRIMETHYLENE OXIDE
503-30-0
|
1g | 99.5%min | 20kg/week | Nanjing jinheyou Trading Co., Ltd. |
-
- TRIMETHYLENE OXIDE
503-30-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- oxetane
503-30-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- TRIMETHYLENE OXIDE
503-30-0
- $0.00
- 99.5%min
- Nanjing jinheyou Trading Co., Ltd.
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