1-(3-Hydroxypropyl)-4-methylpiperazine
- CAS No.
- 5317-33-9
- Chemical Name:
- 1-(3-Hydroxypropyl)-4-methylpiperazine
- Synonyms
- 4-METHYL-1-PIPERAZINEPROPANOL;AKOS BC-0902;CHEMBRDG-BB 4013939;3-(N-METHYLPIPERAZINE)-PROPANOL;1-Piperazinepropanol, 4-methyl-;4-Methyl-1-piperazine-1-propanol;1-(3-Hydroxypropyl)-4-methyl-pipe;3-(N-METHYLPIPERAZINE)-PROPAN-1-OL;3-(4-methyl-1-piperazine)propan-1-ol;3-(4-Methylpiperazin-1-yl)-1-propanol
- CBNumber:
- CB0727644
- Molecular Formula:
- C8H18N2O
- Molecular Weight:
- 158.24
- MDL Number:
- MFCD00009781
- MOL File:
- 5317-33-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 30 °C |
|---|---|
| Boiling point | 75-78°C/0.5mm |
| Density | 0.988±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly) |
| form | Solid |
| pka | 15.10±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C8H18N2O/c1-9-4-6-10(7-5-9)3-2-8-11/h11H,2-8H2,1H3 |
| InChIKey | IIXZEUJZLXHPLB-UHFFFAOYSA-N |
| SMILES | N1(CCCO)CCN(C)CC1 |
| CAS DataBase Reference | 5317-33-9(CAS DataBase Reference) |
| FDA UNII | XB7DBM2RWE |
1-(3-Hydroxypropyl)-4-methylpiperazine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR0881 | 1-(3-Hydroxyprop-1-yl)-4-methylpiperazine 98% | 5317-33-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR0881 | 1-(3-Hydroxyprop-1-yl)-4-methylpiperazine 98% | 5317-33-9 | 5g | $41 | 2026-06-04 | Buy |
| Apolloscientific | OR0881 | 1-(3-Hydroxyprop-1-yl)-4-methylpiperazine 98% | 5317-33-9 | 25g | $96 | 2026-06-04 | Buy |
| Matrix Scientific | 116070 | 3-(N-Methylpiperazine)-propanol | 5317-33-9 | 5.00g | $38 | 2026-05-18 | Buy |
| Matrix Scientific | 116070 | 3-(N-Methylpiperazine)-propanol | 5317-33-9 | 10.00g | $65 | 2026-05-18 | Buy |
1-(3-Hydroxypropyl)-4-methylpiperazine Chemical Properties,Uses,Production
Uses
4-Methyl-1-piperazinepropanol is a useful synthetic organic compound used in the synthesis of S-Alkyl-N-alkylisothiourea compounds.
Synthesis
109-01-3
627-18-9
5317-33-9
General procedure for the synthesis of 1-(3-hydroxypropyl)-4-methylpiperazine from N-methylpiperazine and 3-bromo-1-propanol: Intermediate 7: 3-(4-methylpiperazin-1-yl)-propan-1-ol. Dissolve N-methylpiperazine (6.99 mL, 63 mmol) in toluene (30 mL). 3-Bromo-1-propanol (2.62 mL, 30 mmol) was added slowly and the reaction mixture was stirred at room temperature overnight. Subsequently, the reaction mixture was heated to 80 °C and kept for 2 h, and then cooled to room temperature. The reaction mixture was filtered and the filter cake was washed thoroughly with toluene. After removal of toluene under reduced pressure, the residue was subjected to Kugelrohr distillation (boiling point: 180 °C/2 mbar) to give a colorless oily product (4.08 g, 25.8 mmol, 86% yield). 1H NMR (CDCl3): δ= 1.70 (pseudo quintuple peak, J = 5.8 Hz, 2H), 2.26 (s, 3H), 2.35-2.60 (m, 8H), 2.60 (pseudo triple peak, J = 5.8 Hz, 2H), 3.77 (pseudo triple peak, J = 5.3 Hz, 2H), 4.09 (broad single peak, 1H).
References
[1] Patent: EP1674467, 2006, A1. Location in patent: Page/Page column 26
[2] Patent: EP1674466, 2006, A1. Location in patent: Page/Page column 27
[3] Patent: US2006/142570, 2006, A1. Location in patent: Page/Page column 17
[4] Patent: US2006/135782, 2006, A1. Location in patent: Page/Page column 26
[5] Patent: EP1746096, 2007, A1. Location in patent: Page/Page column 25
1-(3-Hydroxypropyl)-4-methylpiperazine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing BAM Biomedical Technology Co., Ltd. | 18066080842 13952020641 | bamd@foxmail.com | China | 773 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jinan Bond Chemical Technology Co., Ltd. | 86-531-88280989 | mymail1996@126.com | China | 254 | 55 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
View Lastest Price from 1-(3-Hydroxypropyl)-4-methylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
5317-33-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-12-20 | 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
5317-33-9
|
$1.00 | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
5317-33-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
5317-33-9
- $1.00
- 99%
- Career Henan Chemical Co
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