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4,6-Dichloro-2-(methylthio)pyrimidine

4,6-Dichloro-2-(methylthio)pyrimidine Structure
4,6-Dichloro-2-(methylthio)pyrimidine structure
CAS No.
6299-25-8
Chemical Name:
4,6-Dichloro-2-(methylthio)pyrimidine
Synonyms
Pyrimidine, 4,6-dichloro-2-(methylthio)-;4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE;NSC 44560;4,6-Dichloro-2-(meth;4,6-DICHLORO-2-(METHYLTHIO)-;Dichloro-2-(Methylthio)pyriM;4,6-Dichloro-2-(Methylthio)Pyr;4,6-Dichloro-2-Methythiopyrimidine;6-Dichloro-2-(Methylthio)pyriMidine;2-Methylthio-4,6-dichloropyrimidine
CBNumber:
CB2409124
Molecular Formula:
C5H4Cl2N2S
Molecular Weight:
195.07
MDL Number:
MFCD00006086
MOL File:
6299-25-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
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4,6-Dichloro-2-(methylthio)pyrimidine Properties

Melting point 38-42 °C(lit.)
Boiling point 135-136 °C14 mm Hg(lit.)
Density 1.502 (estimate)
refractive index 1.6300 (estimate)
Flash point >230 °F
storage temp. Inert atmosphere,2-8°C
solubility Chloroform, Dichloromethane, Ethyl Acetate
pka -4.86±0.30(Predicted)
form Powder or Crystals
color White to yellow or orange
BRN 127664
InChI 1S/C5H4Cl2N2S/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3
InChIKey FCMLONIWOAGZJX-UHFFFAOYSA-N
SMILES CSc1nc(Cl)cc(Cl)n1
CAS DataBase Reference 6299-25-8(CAS DataBase Reference)
FDA UNII 2Q28U6BR6A
NIST Chemistry Reference Pyrimidine, 4,6-dichloro-2-(methylthio)-(6299-25-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H335
Precautionary statements  P260-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C
Risk Statements  34-36/37
Safety Statements  26-36/37/39-45
RIDADR  UN 3263 8/PG 2
WGK Germany  3
F  10-19
HazardClass  8
PackingGroup  III
HS Code  29335990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
Skin Corr. 1B
STOT SE 3
Limited Quantities 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 0

4,6-Dichloro-2-(methylthio)pyrimidine price More Price(84)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 144533 4,6-Dichloro-2-(methylthio)pyrimidine 98% 6299-25-8 5g $47.6 2026-04-30 Buy
Sigma-Aldrich 144533 4,6-Dichloro-2-(methylthio)pyrimidine 98% 6299-25-8 25g $226 2026-04-30 Buy
TCI Chemical D2533 4,6-Dichloro-2-(methylthio)pyrimidine >98.0%(GC) 6299-25-8 5g $28 2026-04-30 Buy
TCI Chemical D2533 4,6-Dichloro-2-(methylthio)pyrimidine >98.0%(GC) 6299-25-8 25g $77 2026-04-30 Buy
Usbiological D3531-36 4,6-Dichloro-2-(methylthio)pyrimidine 25g $403 2026-06-03 Buy
Product number Packaging Price Buy
144533 5g $47.6 Buy
144533 25g $226 Buy
D2533 5g $28 Buy
D2533 25g $77 Buy
D3531-36 25g $403 Buy

4,6-Dichloro-2-(methylthio)pyrimidine Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

4,6-Dichloro-2-(methylthio)pyrimidine (cas# 6299-25-8) is a compound useful in organic synthesis.

General Description

4,6-Dichloro-2-(methylthio)pyrimidine reacts with (η5-C5H5)Fe(CO)2 to form monometallic and bimetallic complexes.

Synthesis

2-(methylthio)pyrimidine-4,6-diol

1979-98-2

4,6-Dichloro-2-(methylthio)pyrimidine

6299-25-8

Step b: Synthesis of 4,6-dichloro-2-methylthiopyrimidine (19b); 2-methylthiopyrimidine-4,6-diol (30.0 g, 189 mmol) was slowly added to phosphorochloride (350 mL) under cooling in an ice bath, followed by the slow addition of N,N-diethylaniline (52.5 mL) while maintaining cooling. The reaction mixture was gradually warmed to reflux and maintained at reflux for 2.5 hours. Upon completion of the reaction, the mixture was concentrated and subsequently poured into crushed ice for quenching. The aqueous phase was extracted three times with ethyl acetate, and the organic phases were combined and washed sequentially three times with water and once with brine, after which the organic phase was concentrated. The crude product was purified by silica gel column chromatography using hexane-ethyl acetate as eluent to afford 4,6-dichloro-2-methylthiopyrimidine (36 g, 97% yield).

References

[1] Patent: WO2008/95999, 2008, A1. Location in patent: Page/Page column 96
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 29, p. 6547 - 6556
[3] Organic and Biomolecular Chemistry, 2003, vol. 1, # 19, p. 3353 - 3361
[4] ACS Combinatorial Science, 2014, vol. 16, # 4, p. 168 - 175
[5] Journal of Medicinal Chemistry, 1984, vol. 27, # 12, p. 1621 - 1629

4,6-Dichloro-2-(methylthio)pyrimidine Preparation Products And Raw materials

Raw materials

Thiour Sodium Methoxide 2-(methylthio)pyrimidine-4,6-diol

Preparation Products

NSC45719 4-Chloro-6-hydrazino-2-(methylthio)pyrimidine 4-(6-Chloro-2-methylsulfanyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

4,6-Dichloro-2-(methylthio)pyrimidine Suppliers

Global( 375)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Lastest Price from 4,6-Dichloro-2-(methylthio)pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,6-Dichloro-2-(methylthio)pyrimidine pictures 2025-05-23 4,6-Dichloro-2-(methylthio)pyrimidine
6299-25-8
 $50.00-100.00 1kg 99% 20 tons Hebei Zhuanglai Chemical Trading Co Ltd
4,6-Dichloro-2-(methylthio)pyrimidine pictures 2025-04-04 4,6-Dichloro-2-(methylthio)pyrimidine
6299-25-8
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
4,6-Dichloro-2-methylmercaptopyrimidine pictures 2021-07-13 4,6-Dichloro-2-methylmercaptopyrimidine
6299-25-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

4,6-Dichloro-2-(methylthio)pyrimidine Spectrum

4,6-Dichloro-2-(methylthio)pyrimidine(6299-25-8)MS4,6-Dichloro-2-(methylthio)pyrimidine(6299-25-8)1HNMR4,6-Dichloro-2-(methylthio)pyrimidine(6299-25-8)IR14,6-Dichloro-2-(methylthio)pyrimidine(6299-25-8)IR24,6-Dichloro-2-(methylthio)pyrimidine(6299-25-8)Raman

6299-25-8(4,6-Dichloro-2-(methylthio)pyrimidine)Related Search:

4,6-Dichloropyrimidine 4,6-Dichloro-2-methylpyrimidine 2-Methanesulfonyl-4,6-dimethoxypyrimidine Pyrimidine 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE 4,6-DICHLORO-2-METHYLTHIO-PYRIMIDINE, [4,6-14C] 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde 5-(2,4-dichlorophenyl)hydrazone, tech 5-(([(Anilinocarbonyl)oxy]imino)methyl)-4,6-dichloro-2-(methylthio)pyrimidine
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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXALDEHYDE 5-(2,4-DICHLOROPHENYL)HYDRAZONE 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde 5-phenylhydrazone, tech 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde 5-(2,4-dichlorophenyl)hydrazone

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4,6-dichloropyrimidine methyl sulphide 2-Methylthio-4,6-dichloropyrimidine 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE, 9 8% Dichloro-2-methylmercaptopyrimidine,4,6- 4,6-Dichloro-2-(Methylthio)Pyr 4,6-DICHLORO-2-METHYLTHIOPYRIMIDINE 98% 4,6-Dichloro-2-Methythiopyrimidine 4,6-Dichloro-2-(meth 6-Dichloro-2-(Methylthio)pyriMidine 4,6-Dichloro-2-(methylthio)pyrimidine ,99% JR-8367, 4,6-Dichloro-2-(methylthio)pyrimidine, 97% 4,6-Dichloro-2-(Methylthio)pyriMidine, 98% 5GR 2-Methylsulfanyl-4,6-dichloropyriMidine NSC 44560 4,6-DICHLORO-2-THIOMETHYLPYRIMIDINE 4,6-DICHLORO-2-METHYLMERCAPTOPYRIMIDINE 4,6-DICHLORO-2-(METHYLTHIO)- 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE Dichloro-2-(Methylthio)pyriM 4,6-Dichloro-2-(methylsulphanyl)pyrimidine, 4,6-Dichloro-2-(methylmercapto)-1,3-diazine 4,6- twochloro -2-MethylthiopyriMidine 4,6-dichloro-dimethylthiopyrimidine 4,6-Dichloro-2-(methylthio)pyrimidine> 4,6-Dichloro-2-(methylthio)pyrimidine ISO 9001：2015 REACH 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE Pyrimidine, 4,6-dichloro-2-(methylthio)- 6299-25-8 6229-25-8 C5H4Cl2N2S C5H4N2Cl2S C5H4CI2N2S Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Building Blocks Bases & Related Reagents Nucleotides Sulfur & Selenium Compounds Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks Pyrimidine Nucleotides and Nucleosides Halides Pyrazines, Pyrimidines & Pyridazines Heterocycle-Pyrimidine series