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L-Isovaline

L-Isovaline Structure
L-Isovaline structure
CAS No.
595-40-4
Chemical Name:
L-Isovaline
Synonyms
(S)-2-Amino-2-Methylbutanoic Acid;NSC1019;NSC 1019;NSC-1019;L-Isovaline;Isovaline L-;L-isovaline, >97%;a-Me-Gly(Ethyl)-OH;2,3-Dimethylalanine;H-alpha-Et-D-Ala-OH
CBNumber:
CB2430610
Molecular Formula:
C5H11NO2
Molecular Weight:
117.15
MDL Number:
MFCD00800497
MOL File:
595-40-4.mol
MSDS File:
SDS
Last updated:2025-08-08 17:45:00
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L-Isovaline Properties

Melting point 289.39°C (estimate)
Boiling point 213.6±23.0 °C(Predicted)
alpha D25 +11.13° (c = 5 in H2O)
Density 1.2000 (estimate)
refractive index 1.4650 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 2.38±0.10(Predicted)
form Fine Crystalline Powder
color White
optical activity Consistent with structure
InChI InChI=1S/C5H11NO2/c1-3-5(2,6)4(7)8/h3,6H2,1-2H3,(H,7,8)/t5-/m1/s1
InChIKey GCHPUFAZSONQIV-RXMQYKEDSA-N
SMILES C(O)(=O)[C@](CC)(C)N
CAS DataBase Reference 595-40-4(CAS DataBase Reference)
FDA UNII EBV7H5W26H

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Safety Statements  24/25
TSCA  No
NFPA 704
1
1 0

L-Isovaline price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Chem-Impex 33574 ()-2-Amino-2-methylbutyric acid 595-40-4 100MG $40 2021-12-16 Buy
ChemSupplyAustralia 300578 (S)-α-Ethylalanine·H2O, 98% 595-40-4 100mg $41.8 2021-12-16 Buy
ChemScene CS-W020180 L-Isovaline 595-40-4 100mg $54 2021-12-16 Buy
Chem-Impex 33574 ()-2-Amino-2-methylbutyric acid 595-40-4 250MG $70 2021-12-16 Buy
ChemScene CS-W020180 L-Isovaline 595-40-4 250mg $91 2021-12-16 Buy
Product number Packaging Price Buy
33574 100MG $40 Buy
300578 100mg $41.8 Buy
CS-W020180 100mg $54 Buy
33574 250MG $70 Buy
CS-W020180 250mg $91 Buy

L-Isovaline Chemical Properties,Uses,Production

Uses

a-Me-Gly(Ethyl)-OH is used in preparation of peptide compound comprising highly sterically hindered amino acid via reaction of electron-withdrawing group-protected N-unsubstituted-α,α-disubstituted amino acid with peptide followed by N-alkylation.

Synthesis

ETHYL (S)-2-AMINO-2-METHYLBUTYRATE

13893-46-4

L-Isovaline

595-40-4

1.4) Compound F1 (13.8 g, 95.0 mmol) and sodium hydroxide (7.6 g, 190.08 mmol) were added sequentially to a mixture of ethanol (200 mL) and water (1:1 by volume) and heated to reflux for 4 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 7 with 2 M hydrochloric acid solution, followed by evaporation of the solvent. The residue was dissolved in a small amount of water and purified by strongly acidic cation exchange resin 732. The final product G1 (10 g, 90% yield) was obtained as a white solid.

Purification Methods

Crystallise it from aqueous Me2CO, or better by dissolving in H2O and adding excess Me2CO. [Baker et al. J Am Chem Soc 74 4701 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2573-2577 1961.]

References

[1] Patent: CN108440320, 2018, A. Location in patent: Paragraph 0033; 0035; 0043

L-Isovaline Preparation Products And Raw materials

Raw materials

ETHYL (S)-2-AMINO-2-METHYLBUTYRATE Water Sodium hydroxide Ethanol

Preparation Products

L-Isovaline Suppliers

Global( 121)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8617732866630 abby@chuanghaibio.com China 8773 58
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 sales@hbmojin.com China 12371 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32431 58
GL Biochem (Shanghai) Ltd. 		+86-021-61263370 +86-18901917034 CHINA 3904 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
GL Biochem (Shanghai) Ltd. 		58

View Lastest Price from L-Isovaline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Isovaline pictures 2025-08-08 L-Isovaline
595-40-4
 US $100.00 / KG 1KG 99% 5000KG Hebei Mujin Biotechnology Co.,Ltd
L-Isovaline pictures 2025-06-24 L-Isovaline
595-40-4
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
L-Isovaline pictures 2019-07-06 L-Isovaline
595-40-4
 US $1.00 / kg 1kg 98% 100KG Career Henan Chemical Co
  • L-Isovaline pictures
  • L-Isovaline
    595-40-4
  • US $100.00 / KG
  • 99%
  • Hebei Mujin Biotechnology Co.,Ltd
  • L-Isovaline pictures
  • L-Isovaline
    595-40-4
  • US $10.00 / KG
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd
  • L-Isovaline pictures
  • L-Isovaline
    595-40-4
  • US $1.00 / kg
  • 98%
  • Career Henan Chemical Co

L-Isovaline Spectrum

L-Isovaline(595-40-4)1HNMR

595-40-4(L-Isovaline)Related Search:

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L(+)-Isovaline Monohydrate 2,3-Dimethylalanine 2-azanyl-2-methyl-butanoic acid L(+)-Isovaline Monohydrate, (>99% ee), 99+% 250MG (S)-Α-ETHYLALANINE·H2O α-Me-Gly(Ethyl)-OH·H2O (S)-2-Amino-2-Methylbutanoic Acid (S)-(+)-2-Amino-2-methylbutanoicacidmonohydrate(e.e.) (S)-(+)-2-AMINO-2-METHYLBUTANOIC ACID 1-HYDRATE (E.E.) (S)-(+)-2-Amino-2-methylbutanoic acid monohydrate (R)-2-AMINO-2-METHYLBUTYRIC ACID L-Isovaline L-ISO-VALINE((S)-2-AMINO-2-METHYLBUTANOIC ACID) (S)-alpha-Ethylalanine (>98%, >99%ee) H-alpha-Et-D-Ala-OH α-Me-Gly(Ethyl)-OH·H2O (2S)-2-amino-2-methylbutanoic acid 2-(4-ethoxyanilino)-6-(hydroxymethyl)oxane-3,4,5-triol L-isovaline, >97% L-Isovaline USP/EP/BP a-Me-Gly(Ethyl)-OH NSC 1019 NSC1019 NSC-1019 Isovaline L- (S)-α-Ethylalanine?H2O (S)-a-Ethylalanine·H2O 595-40-4 1400942-35-3 Amino Acid Derivatives Valine [Val, V] unnatural amino acids pharmacetical α-Methyl Amino Acids