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L-Isovaline

L-Isovaline Structure
L-Isovaline structure
CAS No.
595-40-4
Chemical Name:
L-Isovaline
Synonyms
(S)-2-Amino-2-Methylbutanoic Acid;NSC1019;NSC 1019;NSC-1019;L-Isovaline;Isovaline L-;L-isovaline, >97%;a-Me-Gly(Ethyl)-OH;2,3-Dimethylalanine;H-alpha-Et-D-Ala-OH
CBNumber:
CB2430610
Molecular Formula:
C5H11NO2
Molecular Weight:
117.15
MDL Number:
MFCD00800497
MOL File:
595-40-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:28:22
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L-Isovaline Properties

Melting point 289.39°C (estimate)
Boiling point 213.6±23.0 °C(Predicted)
alpha D25 +11.13° (c = 5 in H2O)
Density 1.2000 (estimate)
refractive index 1.4650 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 2.38±0.10(Predicted)
form Fine Crystalline Powder
color White
optical activity Consistent with structure
InChI InChI=1S/C5H11NO2/c1-3-5(2,6)4(7)8/h3,6H2,1-2H3,(H,7,8)/t5-/m1/s1
InChIKey GCHPUFAZSONQIV-RXMQYKEDSA-N
SMILES C(O)(=O)[C@](CC)(C)N
CAS DataBase Reference 595-40-4(CAS DataBase Reference)
FDA UNII EBV7H5W26H

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Safety Statements  24/25
TSCA  No
NFPA 704
1
1 0

L-Isovaline price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-W020180 L-Isovaline ≥98% 595-40-4 250mg $40 2026-06-04 Buy
ChemScene CS-W020180 L-Isovaline ≥98% 595-40-4 1g $88 2026-06-04 Buy
ChemScene CS-W020180 L-Isovaline ≥98% 595-40-4 5g $439 2026-06-04 Buy
ChemScene CS-W020180 L-Isovaline ≥98% 595-40-4 10g $75685 2026-06-04 Buy
ChemPep 180782-5G α-Me-Gly(Ethyl)-OH•H2O 595-40-4 5g $800 2026-06-04 Buy
Product number Packaging Price Buy
CS-W020180 250mg $40 Buy
CS-W020180 1g $88 Buy
CS-W020180 5g $439 Buy
CS-W020180 10g $75685 Buy
180782-5G 5g $800 Buy

L-Isovaline Chemical Properties, Uses, Production

Uses

a-Me-Gly(Ethyl)-OH is used in preparation of peptide compound comprising highly sterically hindered amino acid via reaction of electron-withdrawing group-protected N-unsubstituted-α,α-disubstituted amino acid with peptide followed by N-alkylation.

Synthesis

ETHYL (S)-2-AMINO-2-METHYLBUTYRATE

13893-46-4

L-Isovaline

595-40-4

1.4) Compound F1 (13.8 g, 95.0 mmol) and sodium hydroxide (7.6 g, 190.08 mmol) were added sequentially to a mixture of ethanol (200 mL) and water (1:1 by volume) and heated to reflux for 4 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 7 with 2 M hydrochloric acid solution, followed by evaporation of the solvent. The residue was dissolved in a small amount of water and purified by strongly acidic cation exchange resin 732. The final product G1 (10 g, 90% yield) was obtained as a white solid.

Purification Methods

Crystallise it from aqueous Me2CO, or better by dissolving in H2O and adding excess Me2CO. [Baker et al. J Am Chem Soc 74 4701 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2573-2577 1961.]

References

[1] Patent: CN108440320, 2018, A. Location in patent: Paragraph 0033; 0035; 0043

L-Isovaline Preparation Products And Raw materials

Raw materials

Ethyl (S)-2-amino-2-methylbutyrate Water Sodium hydroxide Ethanol

Preparation Products

L-Isovaline Suppliers

Global Suppliers ( 123)
Supplier Tel Email Country ProdList Advantage
Wuxi maimo topp biotechnology co., LTD 15861600115 lisa-li@mimotopes.cn China 5795 58
Suzhou haiyu Biochem Industrial Co., LTD 512-68097639 18013585858 744942877@qq.com China 915 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China Langchem Inc. 0086-21-58956006 China 7798 57
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
Okeanos Tech Co,. Ltd. 010-62651721 18610486005 minghui.yu@okeanos.com.cn China 495 60
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
Beijing innoChem Science & Technology Co.,Ltd. 400-810-7969 010-59572699 ningzi.li@inno-chem.com.cn China 6122 55
Supplier Advantage
Wuxi maimo topp biotechnology co., LTD 58
Suzhou haiyu Biochem Industrial Co., LTD 62
Shanghai Hanhong Scientific Co.,Ltd. 64
China Langchem Inc. 57
ChemPep, Inc. 57
Maya High Purity Chemicals 57
Okeanos Tech Co,. Ltd. 60
T&W GROUP 58
Thermo Fisher Scientific 75
Beijing innoChem Science & Technology Co.,Ltd. 55

View Latest Price from L-Isovaline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Isovaline pictures 2026-03-20 L-Isovaline
595-40-4
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
L-Isovaline pictures 2019-07-06 L-Isovaline
595-40-4
 $1.00 1kg 98% 100KG Career Henan Chemical Co
  • L-Isovaline pictures
  • L-Isovaline
    595-40-4
  • $10.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

L-Isovaline Spectrum

L-Isovaline(595-40-4)1HNMR

595-40-4 (L-Isovaline) Related Search:

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L(+)-Isovaline Monohydrate 2,3-Dimethylalanine 2-azanyl-2-methyl-butanoic acid L(+)-Isovaline Monohydrate, (>99% ee), 99+% 250MG (S)-Α-ETHYLALANINE·H2O α-Me-Gly(Ethyl)-OH·H2O (S)-(+)-2-Amino-2-methylbutanoicacidmonohydrate(e.e.) (S)-(+)-2-AMINO-2-METHYLBUTANOIC ACID 1-HYDRATE (E.E.) (S)-(+)-2-Amino-2-methylbutanoic acid monohydrate (R)-2-AMINO-2-METHYLBUTYRIC ACID L-Isovaline L-ISO-VALINE((S)-2-AMINO-2-METHYLBUTANOIC ACID) (S)-alpha-Ethylalanine (>98%, >99%ee) H-alpha-Et-D-Ala-OH α-Me-Gly(Ethyl)-OH·H2O (2S)-2-amino-2-methylbutanoic acid 2-(4-ethoxyanilino)-6-(hydroxymethyl)oxane-3,4,5-triol L-isovaline, >97% L-Isovaline USP/EP/BP a-Me-Gly(Ethyl)-OH NSC 1019 NSC1019 NSC-1019 Isovaline L- (S)-α-Ethylalanine?H2O (S)-a-Ethylalanine·H2O (S)-2-Amino-2-Methylbutanoic Acid 595-40-4 1400942-35-3 Amino Acid Derivatives Valine [Val, V] unnatural amino acids pharmacetical α-Methyl Amino Acids