Rifalazil
- CAS No.
- 129791-92-0
- Chemical Name:
- Rifalazil
- Synonyms
- KRM 1648;RIFALAZIL;Rifalazil USP/EP/BP;3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin;1-Deoxy-1'-dehydro-1-oxo-3'-hydroxy-5'-[4-(2-methylpropyl)piperazino]rifamycin VIII;5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione
- CBNumber:
- CB2437664
- Molecular Formula:
- C51H64N4O13
- Molecular Weight:
- 941.07
- MDL Number:
- MFCD00871530
- MOL File:
- 129791-92-0.mol
| Product description | Number | Pack Size | Price |
| Rifalazil | R504000 | 50mg | $680 |
| Rifalazil 98.44% | CS-0024983 | 50mg | $680 |
| Rifalazil 98.44% | CS-0024983 | 100mg | $1320 |
| RIFALAZIL 95.00% | API0009212 | 1G | $1637.21 |
| Rifalazil 98.44% | CS-0024983 | 250mg | $2550 |
| Melting point | 195-200° (dec) |
|---|---|
| Boiling point | 1065.6±65.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, away from moisture |
| solubility | DMSO: 8.33 mg/mL (8.85 mM) |
| form | Solid |
| pka | 4.28±0.70(Predicted) |
| color | Blue to dark blue |
| FDA UNII | S1976TE8QK |
Rifalazil price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | R504000 | Rifalazil | 129791-92-0 | 50mg | $680 | 2021-12-16 | Buy |
| ChemScene | CS-0024983 | Rifalazil 98.44% | 129791-92-0 | 50mg | $680 | 2021-12-16 | Buy |
| ChemScene | CS-0024983 | Rifalazil 98.44% | 129791-92-0 | 100mg | $1320 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009212 | RIFALAZIL 95.00% | 129791-92-0 | 1G | $1637.21 | 2021-12-16 | Buy |
| ChemScene | CS-0024983 | Rifalazil 98.44% | 129791-92-0 | 250mg | $2550 | 2021-12-16 | Buy |
Rifalazil Chemical Properties,Uses,Production
Uses
Antibacterial (antimycobacterial).
Uses
Rifalazil has been used as a part of multi drug regimen in the treatment of tuberculosis.
Definition
ChEBI: Rifalazil is a phenoxazine.
in vivo
Rifalazil (oral gavage; 20, 25, and 150 mg/kg; 6-8 weeks) combines with isoniazid (INH) for 6 weeks or greater significantly reduced the number of mice per group in which M. tuberculosis is detected in both spleens and lungs compared to the reductions for the early and late controls. And the addition of Pyrazinamide (PZA) does not significantly improve RLZ-INH therapy at any time point[2].
| Animal Model: | Female CD-1 mice infected with 5.2 × 107viable mycobacteria[2] |
| Dosage: | 20, 25, and 150 mg/kg; 6-8 weeks |
| Administration: | Oral gavage |
| Result: | Combined with isoniazid (INH) showed its potential for short-course treatment ofMycobacterium tuberculosisinfection. |
Rifalazil Preparation Products And Raw materials
Raw materials
Preparation Products
Rifalazil Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7099 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8497 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33325 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5167 | 58 |
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