Phenylglyoxal monohydrate
- CAS No.
- 1075-06-5
- Chemical Name:
- Phenylglyoxal monohydrate
- Synonyms
- PHENYLGLYOXAL;PHENYLGLYOXAL HYDRATE;2,2-Dihydroxy-1-phenylethan-1-one;Ethanone, 2,2-dihydroxy-1-phenyl-;2,2-dihydroxy-acetophenon;2,2-DIHYDROXY-1-PHENYL-ETHANONE;Phenylglyoxal hydrate 97%;2,2-dihydroxyacetophenone;Phenylglyoxal monohydrate;P-PHENYLGLYOXAL MONOHYDRATE
- CBNumber:
- CB3454176
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00149499
- MOL File:
- 1075-06-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 76-79 °C(lit.) |
|---|---|
| Boiling point | 142 °C125 mm Hg(lit.) |
| Density | 1.1603 (rough estimate) |
| refractive index | 1.5120 (estimate) |
| Flash point | 142°C/125mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 95% ethanol: soluble5%, clear to very slightly hazy, colorless to light yellow |
| pka | 10.97±0.41(Predicted) |
| form | Powder |
| color | White to light yellow or pinkish |
| Water Solubility | Partly miscible with water. |
| BRN | 1854721 |
| InChI | 1S/C8H6O2.H2O/c9-6-8(10)7-4-2-1-3-5-7;/h1-6H;1H2 |
| InChIKey | YQBLQKZERMAVDO-UHFFFAOYSA-N |
| SMILES | [H]O[H].[H]C(=O)C(=O)c1ccccc1 |
| CAS DataBase Reference | 1075-06-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MD3260000 | |||||||||
| HS Code | 2914.40.4000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | mouse,LD50,oral,500mg/kg (500mg/kg),Journal of Medicinal and Pharmaceutical Chemistry. Vol. 1, Pg. 365, 1959. | |||||||||
| NFPA 704 |
|
Phenylglyoxal monohydrate price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 142433 | Phenylglyoxal hydrate 97% | 1075-06-5 | 5g | $84 | 2026-04-30 | Buy |
| Sigma-Aldrich | 142433 | Phenylglyoxal hydrate 97% | 1075-06-5 | 25g | $234 | 2026-04-30 | Buy |
| TCI Chemical | P0652 | Phenylglyoxal Monohydrate >98.0%(GC) | 1075-06-5 | 5g | $295 | 2026-04-30 | Buy |
| TCI Chemical | P0652 | Phenylglyoxal Monohydrate >98.0%(GC) | 1075-06-5 | 25g | $892 | 2026-04-30 | Buy |
| ChemScene | CS-0099611 | 2,2-Dihydroxy-1-phenylethan-1-one ≥96% | 1075-06-5 | 250mg | $7 | 2026-06-04 | Buy |
Phenylglyoxal monohydrate Chemical Properties,Uses,Production
Uses
Phenylglyoxal monohydrate was used to modify pig muscle carbonic anhydraseIII and as a specific reagent for arginine groups. It was also used to prepare pyrrolinone and furan derivatives and as as a chemiluminescent reagent for the determination of purines.
Biochem/physiol Actions
Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.
Synthesis
98-86-2
1075-06-5
GENERAL METHOD: Selenium dioxide (220 mg, 2 mmol) was dissolved in a mixed solution of 1,4-dioxane (1 mL) and deionized water (2 drops), followed by the addition of acetophenone 1a (120 mg, 1 mmol). The reaction mixture was refluxed with stirring for 7 h (the reaction progress was monitored by TLC, the unfolding agent was ethyl acetate/petroleum ether, 1:4, v/v). After completion of the reaction, it was cooled to room temperature, dichloromethane (5 mL) was added to the mixture and filtered through diatomaceous earth. The diatomaceous earth was washed with dichloromethane (3 x 5 mL). All organic phases were combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:10 v/v) to give benzoylformaldehyde hydrate 2a (121 mg, 80% yield). Compounds 2b~2m were synthesized following the same procedure in a range of 61%~82% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1660 - 1664
[2] Tetrahedron Asymmetry, 2010, vol. 21, # 18, p. 2244 - 2248
[3] Tetrahedron, 2011, vol. 67, # 41, p. 8000 - 8008
[4] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 1, p. 51 - 57
[5] Khim. Geterotsikl. Soedin., 2018, vol. 54, # 1, p. 51 - 57,7
Phenylglyoxal monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Phenylglyoxal monohydrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
View Lastest Price from Phenylglyoxal monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-04 | 2,2-Dihydroxy-1-phenylethan-1-one
1075-06-5
|
$29.00 | 98.15% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-02-02 | Phenylglyoxal Monohydrate
1075-06-5
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-12-24 | PHENYLGLYOXAL MONOHYDRATE
1075-06-5
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 2,2-Dihydroxy-1-phenylethan-1-one
1075-06-5
- $29.00
- 98.15%
- TargetMol Chemicals Inc.
-
- Phenylglyoxal Monohydrate
1075-06-5
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- PHENYLGLYOXAL MONOHYDRATE
1075-06-5
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
1075-06-5(Phenylglyoxal monohydrate)Related Search:
1of4
