Olprinone
- CAS No.
- 106730-54-5
- Chemical Name:
- Olprinone
- Synonyms
- LOPRINONE;OLPRINONE;Olprinone [inn];Olprinone USP/EP/BP;Olprinone(Loprinone);Olprinone, 10 mM in DMSO;3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester;1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile;1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
- CBNumber:
- CB2438515
- Molecular Formula:
- C14H10N4O
- Molecular Weight:
- 250.26
- MDL Number:
- MFCD25541649
- MOL File:
- 106730-54-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300° |
|---|---|
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO |
| form | Powder |
| pka | 6.59±0.10(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19) |
| InChIKey | JPAWFIIYTJQOKW-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(C)=C(C2=CN3C=CN=C3C=C2)C=C1C#N |
| CAS DataBase Reference | 106730-54-5(CAS DataBase Reference) |
| FDA UNII | 4Y8BMI9YGC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Olprinone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GEA73054 | Olprinone | 106730-54-5 | 250mg | $1165 | 2026-06-04 | Buy |
| ChemScene | CS-1190 | Olprinone 99.58% | 106730-54-5 | 5mg | $32 | 2026-06-04 | Buy |
| ChemScene | CS-1190 | Olprinone 99.58% | 106730-54-5 | 10mg | $50 | 2026-06-04 | Buy |
| ChemScene | CS-1190 | Olprinone 99.58% | 106730-54-5 | 25mg | $100 | 2026-06-04 | Buy |
| ChemScene | CS-1190 | Olprinone 99.58% | 106730-54-5 | 50mg | $151 | 2026-06-04 | Buy |
Olprinone Chemical Properties, Uses, Production
Description
Oprinone is an injection developed by Japan Co., Ltd. for the treatment of acute heart failure. It is a specific PDEⅢ inhibitor that selectively blocks cAMP and has high selectivity for the inhibition of human cardiac PDEⅢ.
Uses
Olprinone is used in the treatment of acute myocardial insufficiency.
Definition
ChEBI: Olprinone is a member of bipyridines.
Side effects
1. In the treatment of heart failure, the main adverse reactions of opprinone are manifested in the circulatory system, including premature ventricular contraction, tachycardia, increased ventricular tachyarrhythmia, and increased heart rate. Electric monitoring;
2. As a vasodilator, patients with renal insufficiency should use it in low doses. Long-term oral administration may lead to increased long-term mortality due to large adverse reactions, so it is only used for a short period of time.
Synthesis
4-(Dimethylamino)-3-(pyrimido[1,2-α]pyridin-6-yl)-3-buten-2-one and cyanoacetamide in dimethylformamide at 80~ Heating at 90°C for 12h to obtain Operinone.
References
[1] Patent: CN106349246, 2017, A. Location in patent: Paragraph 0023; 0028; 0029
Olprinone Preparation Products And Raw materials
Olprinone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Sanyuan Chemical Co. LTD | 18615587029 | 3382711390@qq.com | China | 330 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd | 18901358086 | pharma_reese@126.com | China | 48 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| China Nobel Chem Co., Limited | +86(0)21 60484900 | China | 762 | 50 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
View Latest Price from Olprinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Olprinone
106730-54-5
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-05-10 | Olprinone
106730-54-5
|
1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | Olprinone
106730-54-5
|
1KG | 98% | 150KG | Career Henan Chemical Co |
106730-54-5 (Olprinone) Related Search:
1of4
