3-Chloro-4-(trifluoromethoxy)benzaldehyde
- CAS No.
- 83279-38-3
- Chemical Name:
- 3-Chloro-4-(trifluoromethoxy)benzaldehyde
- Synonyms
- 3-chloro-4-trifluoromethoxybenaldehyde;3-Chloro-4-(trifluoromethoxy)benzaldehyde;Benzaldehyde, 3-chloro-4-(trifluoromethyl)-
- CBNumber:
- CB2461898
- Molecular Formula:
- C8H4ClF3O
- Molecular Weight:
- 208.57
- MDL Number:
- MFCD03095197
- MOL File:
- 83279-38-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P261-P271 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2913000090 | |||||||||
| NFPA 704 |
|
3-Chloro-4-(trifluoromethoxy)benzaldehyde price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS114371 | 3-Chloro-4-(trifluoromethyl)benzaldehyde 95% | 83279-38-3 | 1g | $28 | 2026-06-04 | Buy |
| Activate Scientific | AS114371 | 3-Chloro-4-(trifluoromethyl)benzaldehyde 95% | 83279-38-3 | 5g | $80 | 2026-06-04 | Buy |
| Activate Scientific | AS114371 | 3-Chloro-4-(trifluoromethyl)benzaldehyde 95% | 83279-38-3 | 25g | $386 | 2026-06-04 | Buy |
| aablocks | AA004XE4 | 3-Chloro-4-(trifluoromethyl)benzaldehyde 98% | 83279-38-3 | 1g | $13 | 2026-05-28 | Buy |
| aablocks | AA004XE4 | 3-Chloro-4-(trifluoromethyl)benzaldehyde 98% | 83279-38-3 | 5g | $34 | 2026-05-28 | Buy |
3-Chloro-4-(trifluoromethoxy)benzaldehyde Chemical Properties, Uses, Production
Uses
3-Chloro-4-(trifluoromethyl)benzaldehyde is used in synthesis of organic compunds in γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines.
Synthesis
1092460-79-1
83279-38-3
The general procedure for the synthesis of 3-chloro-4-trifluoromethylbenzonitrile from 3-chloro-4-trifluoromethylbenzaldehyde was as follows: at 0 °C, using a syringe, diisobutylaluminum hydride (1.0 M toluene solution, 28 mL, 28 mmol) was added slowly and dropwise to 3-chloro-4-(trifluoromethyl)benzonitrile (3.79 g, 18.4 mmol) in tetrahydrofuran (THF, 50 mL ) solution. The reaction mixture was kept at 0 °C for 2 h, followed by warming to room temperature and continued stirring for 2 h. The reaction was carried out on a cooled surface. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with 3M aqueous hydrochloric acid solution (75 mL). The mixture was warmed to room temperature and stirred vigorously for 1.5 hours. Subsequently, the mixture was transferred to a dispensing funnel and diluted with ether (Et2O). The organic phase was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Purification by fast chromatography (Analogix IntelliFlash 280 system, using 15% ethyl acetate/hexane as eluent, SF40-150g column) gave 2.84 g (74% yield) of 3-chloro-4-trifluoromethylbenzaldehyde as a colorless oil. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 10.09 (s, 1H), 8.21 (s, 1H), 8.12 (d, J = 8.1 Hz, 1H), 8.07-8.02 (m, 1H).
References
[1] Patent: US2009/124666, 2009, A1. Location in patent: Page/Page column 30-32
3-Chloro-4-(trifluoromethoxy)benzaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 3-Chloro-4-(trifluoromethoxy)benzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-08-01 | 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
83279-38-3
|
$1.00 | 1KG | 95-99% | 1MT/month | Career Henan Chemical Co |
-
- 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
83279-38-3
- $1.00
- 95-99%
- Career Henan Chemical Co
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