AE-3763
- CAS No.
- 291778-77-3
- Chemical Name:
- AE-3763
- Synonyms
- AE-3763;2-(3-(2-(((S)-3-methyl-1-oxo-1-((S)-2-(((S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl)pyrrolidin-1-yl)butan-2-yl)amino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)acetic acid;1-Imidazolidineacetic acid, 3-[2-[[(1S)-2-methyl-1-[[(2S)-2-[[[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]propyl]amino]-2-oxoethyl]-2-oxo-
- CBNumber:
- CB24694528
- Molecular Formula:
- C23H34F3N5O7
- Molecular Weight:
- 549.54
- MDL Number:
- MFCD30532567
- MOL File:
- 291778-77-3.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
| FDA UNII | F7YC3C4YFS |
AE-3763 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RLA77877 | AE-3763 | 291778-77-3 | 5mg | $1455.4 | 2026-06-05 | Buy |
| Biosynth | RLA77877 | AE-3763 | 291778-77-3 | 10mg | $2328.6 | 2026-06-05 | Buy |
| Biosynth | RLA77877 | AE-3763 | 291778-77-3 | 25mg | $4366.25 | 2026-06-05 | Buy |
| Biosynth | RLA77877 | AE-3763 | 291778-77-3 | 50mg | $6985.5 | 2026-06-05 | Buy |
| ChemScene | CS-0015506 | AE-3763 99.82% | 291778-77-3 | 5mg | $395 | 2026-06-04 | Buy |
AE-3763 Chemical Properties, Uses, Production
Uses
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
in vivo
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv[1].
References
[1] Inoue Y, et al. Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem. 2009 Nov 1;17(21):7477-86. DOI:10.1016/j.bmc.2009.09.020
AE-3763 Preparation Products And Raw materials
Raw materials
Preparation Products
AE-3763 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Shandong Ziyi Pharmaceutical Co., Ltd. | 17860786593 | 1181917242@qq.com | China | 9999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
