Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CYM-5478

CYM-5478

CYM-5478 Structure
CYM-5478 structure
CAS No.
870762-83-7
Chemical Name:
CYM-5478
Synonyms
CYM-5478;1-[2-(1-Benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]-5-(trifluoromethyl) pyridin-2-one;1-[2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]-5-(trifluoromethyl)-1,2-dihydropyridin-2-one;1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)-2(1H)-pyridinone;2(1H)-Pyridinone, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)-
CBNumber:
CB24718602
Molecular Formula:
C21H19F3N2O2
Molecular Weight:
388.38
MDL Number:
MFCD07342414
MOL File:
870762-83-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:32:01
Request For Quotation

CYM-5478 Properties

Boiling point 527.1±50.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble
form A crystalline solid
pka -2.22±0.70(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H302-H335-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

CYM-5478 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29024 CYM 5478 ≥98% 870762-83-7 1mg $103 2026-04-30 Buy
Cayman Chemical 29024 CYM 5478 ≥98% 870762-83-7 5mg $454 2026-04-30 Buy
ChemScene CS-0034768 CYM-5478 99.44% 870762-83-7 1mg $97 2026-06-04 Buy
ChemScene CS-0034768 CYM-5478 99.44% 870762-83-7 5mg $368 2026-06-04 Buy
ChemScene CS-0034768 CYM-5478 99.44% 870762-83-7 10mg $516 2026-06-04 Buy
Product number Packaging Price Buy
29024 1mg $103 Buy
29024 5mg $454 Buy
CS-0034768 1mg $97 Buy
CS-0034768 5mg $368 Buy
CS-0034768 10mg $516 Buy

CYM-5478 Chemical Properties, Uses, Production

Description

CYM 5478 is a sphingosine-1-phosphate receptor 2 (S1P2) agonist (EC50 = 0.78 μM in a reporter assay). It is selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively). CYM 5478 (0.1-10 μM) reduces serum starvation-induced decreases in C6 rat glioma cell viability. It also reduces accumulation of reactive oxygen species (ROS) and apoptosis induced by cisplatin in C6 cells when used at a concentration of 10 μM.

Uses

CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity[1][2].

in vivo

CYM-5478 (1 mg/kg/day; ip) protects against Cisplatin-mediated (3 mg/kg; i.p.; once a week for 3 week) ototoxicity in rats[2].
CYM-5478 (20 μM) treatment results in near-complete protection from cisplatin-mediated loss of neuromast viability. CYM-5478 protects against loss of hair cell viability in a zebrafish model for ototoxicity[2].

IC 50

S1PR2: 119 nM (EC50); S1PR1: 1690 nM (EC50); S1PR3: 1950 nM (EC50); S1PR4: >10 μM (EC50); S1PR5: >10 μM (IC50)

References

[1] Deron R Herr, et al. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Sci Rep. 2016 Apr 15;6:24541. DOI:10.1038/srep24541
[2] Wei Wang, et al. Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment. Cancers (Basel). 2020 Jan 15;12(1):211. DOI:10.3390/cancers12010211

CYM-5478 Preparation Products And Raw materials

Raw materials

Preparation Products

CYM-5478 Suppliers

Global Suppliers ( 20)
Supplier Tel Email Country ProdList Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4866 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25030 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
cjbscvictory 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Shanghai Universal Biotech Co.,Ltd 58
TargetMol Chemicals Inc. 58

View Latest Price from CYM-5478 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CYM-5478 pictures 2026-05-11 CYM-5478
870762-83-7
 $73.00-278.00 99.92% 10g TargetMol Chemicals Inc.
  • CYM-5478 pictures
  • CYM-5478
    870762-83-7
  • $73.00-278.00
  • 99.92%
  • TargetMol Chemicals Inc.

870762-83-7 (CYM-5478) Related Search:

2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride 1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxo-ethyl]-6-oxo-1,6-dihydro-pyridine-3-carbonitrile 5,6-Benzoflavone N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide CYM50308
(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt

1of2

CYM-5478 2(1H)-Pyridinone, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)- 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)-2(1H)-pyridinone 1-[2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]-5-(trifluoromethyl)-1,2-dihydropyridin-2-one 1-[2-(1-Benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]-5-(trifluoromethyl) pyridin-2-one 870762-83-7