CYM-5478 manufacturers
- CYM-5478
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- $73.00
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2026-05-11
- CAS:870762-83-7
- Purity: 99.92%
- Supply Ability: 10g
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| | CYM-5478 Basic information |
| Product Name: | CYM-5478 | | Synonyms: | CYM-5478;2(1H)-Pyridinone, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)-;1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)-2(1H)-pyridinone;1-[2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]-5-(trifluoromethyl)-1,2-dihydropyridin-2-one;1-[2-(1-Benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]-5-(trifluoromethyl) pyridin-2-one | | CAS: | 870762-83-7 | | MF: | C21H19F3N2O2 | | MW: | 388.38 | | EINECS: | | | Product Categories: | | | Mol File: | 870762-83-7.mol |  |
| | CYM-5478 Chemical Properties |
| Boiling point | 527.1±50.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | -2.22±0.70(Predicted) | | color | White to off-white |
| | CYM-5478 Usage And Synthesis |
| Description | CYM 5478 is a sphingosine-1-phosphate receptor 2 (S1P2) agonist (EC50 = 0.78 μM in a reporter assay). It is selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively). CYM 5478 (0.1-10 μM) reduces serum starvation-induced decreases in C6 rat glioma cell viability. It also reduces accumulation of reactive oxygen species (ROS) and apoptosis induced by cisplatin in C6 cells when used at a concentration of 10 μM. | | Uses | CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity[1][2]. | | in vivo | CYM-5478 (1 mg/kg/day; ip) protects against Cisplatin-mediated (3 mg/kg; i.p.; once a week for 3 week) ototoxicity in rats[2].
CYM-5478 (20 μM) treatment results in near-complete protection from cisplatin-mediated loss of neuromast viability. CYM-5478 protects against loss of hair cell viability in a zebrafish model for ototoxicity[2].
| | IC 50 | S1PR2: 119 nM (EC50); S1PR1: 1690 nM (EC50); S1PR3: 1950 nM (EC50); S1PR4: >10 μM (EC50); S1PR5: >10 μM (IC50) | | References | [1] Deron R Herr, et al. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Sci Rep. 2016 Apr 15;6:24541. DOI:10.1038/srep24541
[2] Wei Wang, et al. Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment. Cancers (Basel). 2020 Jan 15;12(1):211. DOI:10.3390/cancers12010211 |
| | CYM-5478 Preparation Products And Raw materials |
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