IMB-808
- CAS No.
- 870768-70-0
- Chemical Name:
- IMB-808
- Synonyms
- IMB-808;IMB808,IMB 808;2,3-Dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]-1,4-benzodioxin-6-carboxamide;1,4-Benzodioxin-6-carboxamide, 2,3-dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]-;N-Methyl-N-(2-oxo-2-((2,3,4-trifluorophenyl)amino)ethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide
- CBNumber:
- CB24718622
- Molecular Formula:
- C18H15F3N2O4
- Molecular Weight:
- 380.32
- MDL Number:
- MFCD07342695
- MOL File:
- 870768-70-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: 2mg/mL, clear |
| form | Solid |
| color | White to off-white |
| InChI | 1S/C18H15F3N2O4/c1-23(9-15(24)22-12-4-3-11(19)16(20)17(12)21)18(25)10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8H,6-7,9H2,1H3,(H,22,24) |
| InChIKey | XITZPIXICJOKTF-UHFFFAOYSA-N |
| SMILES | FC1=C(NC(CN(C)C(C2=CC(OCCO3)=C3C=C2)=O)=O)C=CC(F)=C1F |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
IMB-808 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42448 | IMB-808 ≥98% | 870768-70-0 | 5mg | $79 | 2026-04-30 | Buy |
| Cayman Chemical | 42448 | IMB-808 ≥98% | 870768-70-0 | 10mg | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 42448 | IMB-808 ≥98% | 870768-70-0 | 25mg | $352 | 2026-04-30 | Buy |
| Biosynth | VJB76870 | IMB-808 | 870768-70-0 | 25mg | $343.75 | 2026-06-05 | Buy |
| Biosynth | VJB76870 | IMB-808 | 870768-70-0 | 100mg | $825 | 2026-06-05 | Buy |
IMB-808 Chemical Properties, Uses, Production
Description
IMB-808 is a potent liver X receptor α and β (LXRα/β) partial dual agonist that promotes expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1).
Uses
IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research[1].
References
[1] Duo Lu, et al. Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics. Mol Pharmacol. 2017 Apr;91(4):264-276. DOI:10.1124/mol.116.105213
IMB-808 Preparation Products And Raw materials
Raw materials
Preparation Products
IMB-808 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Aikon International Limited | 025-58859352 18651614124 | 2881516338@qq.com | China | 9968 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
