IMB-808 manufacturers
- IMB-808
-
- $45.00
-
2026-04-22
- CAS:870768-70-0
- Purity: 99.93%
- Supply Ability: 10g
|
| | IMB-808 Basic information |
| Product Name: | IMB-808 | | Synonyms: | IMB-808;1,4-Benzodioxin-6-carboxamide, 2,3-dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]-;IMB808,IMB 808;2,3-Dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]-1,4-benzodioxin-6-carboxamide;N-Methyl-N-(2-oxo-2-((2,3,4-trifluorophenyl)amino)ethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide | | CAS: | 870768-70-0 | | MF: | C18H15F3N2O4 | | MW: | 380.32 | | EINECS: | | | Product Categories: | | | Mol File: | 870768-70-0.mol |  |
| | IMB-808 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | form | Solid | | color | White to off-white | | InChI | 1S/C18H15F3N2O4/c1-23(9-15(24)22-12-4-3-11(19)16(20)17(12)21)18(25)10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8H,6-7,9H2,1H3,(H,22,24) | | InChIKey | XITZPIXICJOKTF-UHFFFAOYSA-N | | SMILES | FC1=C(NC(CN(C)C(C2=CC(OCCO3)=C3C=C2)=O)=O)C=CC(F)=C1F |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | IMB-808 Usage And Synthesis |
| Description | IMB-808 is a potent liver X receptor α and β (LXRα/β) partial dual agonist that promotes expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1). | | Uses | IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research[1]. | | References | [1] Duo Lu, et al. Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics. Mol Pharmacol. 2017 Apr;91(4):264-276. DOI:10.1124/mol.116.105213 |
| | IMB-808 Preparation Products And Raw materials |
|