5-Chloro-2-hydroxy-3-nitropyridine
- CAS No.
- 21427-61-2
- Chemical Name:
- 5-Chloro-2-hydroxy-3-nitropyridine
- Synonyms
- 5-Chlo;NSC 64258;5-Chloro-3-nitro-2-pyridone;5-CHLORO-3-NITRO-2-PYRIDINOL;5-CHLORO-3-NITROPYRIDIN-2-OL;oro-2-hydroxy-3-nitropyridine;5-chloro-3-nitro-1H-pyridin-2-one;5-Chloro-3-nitro-2(1H)-pyridinone;5-chloro-3-nitropyridin-2(1H)-one;5-Chloro-3-nitropyridin-2-ol, 95+%
- CBNumber:
- CB2479170
- Molecular Formula:
- C5H3ClN2O3
- Molecular Weight:
- 174.54
- MDL Number:
- MFCD00114884
- MOL File:
- 21427-61-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 232-236 °C |
|---|---|
| Boiling point | 284.1±40.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Dimethylformamide |
| form | powder to crystal |
| pka | 6.31±0.10(Predicted) |
| color | Light yellow to Yellow to Green |
| BRN | 383852 |
| InChI | 1S/C5H3ClN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9) |
| InChIKey | QVGQNICXNZMXQA-UHFFFAOYSA-N |
| SMILES | Oc1ncc(Cl)cc1[N+]([O-])=O |
| CAS DataBase Reference | 21427-61-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-39-36-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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5-Chloro-2-hydroxy-3-nitropyridine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 679747 | 5-Chloro-2-hydroxy-3-nitropyridine 97% | 21427-61-2 | 1g | $124 | 2023-01-07 | Buy |
| TCI Chemical | C1972 | 5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T) | 21427-61-2 | 5g | $109 | 2026-04-30 | Buy |
| TCI Chemical | C1972 | 5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T) | 21427-61-2 | 25g | $323 | 2026-04-30 | Buy |
| AstaTech | CL0213 | 5-CHLORO-2-HYDROXY-3-NITROPYRIDINE 97% | 21427-61-2 | 25G | $77 | 2026-04-30 | Buy |
| Apolloscientific | OR9001 | 5-Chloro-2-hydroxy-3-nitropyridine 95% | 21427-61-2 | 1g | $21 | 2026-06-04 | Buy |
5-Chloro-2-hydroxy-3-nitropyridine Chemical Properties, Uses, Production
Chemical Properties
White to light brown solid
Uses
5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis.
Synthesis
1072-98-6
21427-61-2
Preparation of Example A2 5-chloro-2-hydroxy-3-nitropyridine (STR9): 321 g of 2-amino-5-chloropyridine was slowly added dropwise to 1.25 L of concentrated sulfuric acid with continuous stirring until the raw material was completely dissolved. Subsequently, 172.5 g of sodium nitrite (dissolved in 240 mL of water) was slowly added at 40°C to 45°C and the reaction mixture continued to be stirred for 15 minutes. Next, 125 mL of pure nitric acid was slowly added dropwise over 40 minutes at 50°C. The reaction mixture was maintained at 55°C for 1 hour and then the reaction was quenched by pouring into 5 kg of ice water. The yellow precipitated product was collected by filtration, washed thoroughly with deionized water and dried at 60°C to afford 351 g of 5-chloro-2-hydroxy-3-nitropyridine in 80.5% of the theoretical yield and a melting point of 229°C to 231°C.
References
[1] Patent: US5274100, 1993, A
[2] Yakugaku Zasshi, 1952, vol. 72, p. 431
[3] Chem.Abstr., 1953, p. 6404
5-Chloro-2-hydroxy-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 5-Chloro-2-hydroxy-3-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
