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5-Chloro-2-hydroxy-3-nitropyridine

5-Chloro-2-hydroxy-3-nitropyridine structure

CAS No.: 21427-61-2

Chemical Name:: 5-Chloro-2-hydroxy-3-nitropyridine

Synonyms: 5-Chlo;NSC 64258;5-Chloro-3-nitro-2-pyridone;5-CHLORO-3-NITRO-2-PYRIDINOL;5-CHLORO-3-NITROPYRIDIN-2-OL;oro-2-hydroxy-3-nitropyridine;5-chloro-3-nitro-1H-pyridin-2-one;5-Chloro-3-nitro-2(1H)-pyridinone;5-chloro-3-nitropyridin-2(1H)-one;5-Chloro-3-nitropyridin-2-ol, 95+%

CBNumber:: CB2479170

Molecular Formula:: C5H3ClN2O3

Molecular Weight:: 174.54

MDL Number:: MFCD00114884

MOL File:: 21427-61-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:35:25

Product description	Number	Pack Size	Price
5-Chloro-2-hydroxy-3-nitropyridine 97%	679747	1g	$124
5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T)	C1972	5g	$109
5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T)	C1972	25g	$323
5-CHLORO-2-HYDROXY-3-NITROPYRIDINE 97%	CL0213	25G	$77
5-Chloro-2-hydroxy-3-nitropyridine 95%	OR9001	1g	$21
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5-Chloro-2-hydroxy-3-nitropyridine Properties

Melting point	232-236 °C
Boiling point	284.1±40.0 °C(Predicted)
Density	1.61±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Dimethylformamide
form	powder to crystal
pka	6.31±0.10(Predicted)
color	Light yellow to Yellow to Green
BRN	383852
InChI	1S/C5H3ClN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)
InChIKey	QVGQNICXNZMXQA-UHFFFAOYSA-N
SMILES	Oc1ncc(Cl)cc1[N+]([O-])=O
CAS DataBase Reference	21427-61-2(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P261-P280-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-41-37/38-22

Safety Statements

26-36/37/39-39-36-37

WGK Germany

HazardClass

IRRITANT

HS Code

29337900

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

5-Chloro-2-hydroxy-3-nitropyridine price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	679747	5-Chloro-2-hydroxy-3-nitropyridine 97%	21427-61-2	1g	$124	2023-01-07	Buy
TCI Chemical	C1972	5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T)	21427-61-2	5g	$109	2026-04-30	Buy
TCI Chemical	C1972	5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T)	21427-61-2	25g	$323	2026-04-30	Buy
AstaTech	CL0213	5-CHLORO-2-HYDROXY-3-NITROPYRIDINE 97%	21427-61-2	25G	$77	2026-04-30	Buy
Apolloscientific	OR9001	5-Chloro-2-hydroxy-3-nitropyridine 95%	21427-61-2	1g	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
679747	1g	$124	Buy
C1972	5g	$109	Buy
C1972	25g	$323	Buy
CL0213	25G	$77	Buy
OR9001	1g	$21	Buy

5-Chloro-2-hydroxy-3-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

White to light brown solid

Uses

5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis.

Synthesis

1072-98-6

21427-61-2

Preparation of Example A2 5-chloro-2-hydroxy-3-nitropyridine (STR9): 321 g of 2-amino-5-chloropyridine was slowly added dropwise to 1.25 L of concentrated sulfuric acid with continuous stirring until the raw material was completely dissolved. Subsequently, 172.5 g of sodium nitrite (dissolved in 240 mL of water) was slowly added at 40°C to 45°C and the reaction mixture continued to be stirred for 15 minutes. Next, 125 mL of pure nitric acid was slowly added dropwise over 40 minutes at 50°C. The reaction mixture was maintained at 55°C for 1 hour and then the reaction was quenched by pouring into 5 kg of ice water. The yellow precipitated product was collected by filtration, washed thoroughly with deionized water and dried at 60°C to afford 351 g of 5-chloro-2-hydroxy-3-nitropyridine in 80.5% of the theoretical yield and a melting point of 229°C to 231°C.

References

[1] Patent: US5274100, 1993, A
[2] Yakugaku Zasshi, 1952, vol. 72, p. 431
[3] Chem.Abstr., 1953, p. 6404

5-Chloro-2-hydroxy-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-chloropyridine Nitric acid Sulfuric acid Sodium nitrite

Preparation Products

2-Bromo-5-chloro-3-nitropyridine 3-AMINO-2-BROMO-5-CHLOROPYRIDINE

5-Chloro-2-hydroxy-3-nitropyridine Suppliers

Global( 223)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20120	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8828	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 5-Chloro-2-hydroxy-3-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-09	5-Chloro-2-hydroxy-3-nitropyridine 21427-61-2	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-06-30	5-Chloro-2-hydroxy-3-nitropyridine 21427-61-2		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-03-20	5-Chloro-2-hydroxy-3-nitropyridine 21427-61-2	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
$5.00
98%
Henan Fengda Chemical Co., Ltd

5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
98.0%
Shaanxi Dideu New Materials Co. Ltd

5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Chloro-2-hydroxy-3-nitropyridine Spectrum

5-Chloro-2-hydroxy-3-nitropyridine(21427-61-2)¹HNMR

21427-61-2(5-Chloro-2-hydroxy-3-nitropyridine)Related Search:

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5-CHLORO-2-HYDROXY-3-NITROPYRIDINE 5-CHLORO-3-NITROPYRIDIN-2-OL 5-CHLORO-3-NITRO-2-PYRIDINOL 2-hydroxy-3-nitro-5-chloropyridine 5-Chloro-3-nitropyridin-2-ol, 95+% 5-Chloro-2-hydroxy-3-nitropyridine 95+% 5-Chloro-2-hydroxy-3-nitropyridine ,97% 2-Hydroxy-5-chloro-3-nitropyridine 5-Chloro-3-nitro-2(1H)-pyridinone NSC 64258 5-chloro-3-nitro-1H-pyridin-2-one 5-Chlo 5-Chloro-2-hydroxy-3-nitropyridine > oro-2-hydroxy-3-nitropyridine 2(1H)-Pyridinone, 5-chloro-3-nitro- 5-Chloro-3-nitro-2-pyridone 5-Chloro-2-hydroxy-3-nitropyridine ISO 9001：2015 REACH 5-CHLORO-3-NITRO-2-PYRIDONE (2-HYDROXY-3-NITRO-5-CHLOROPYRIDINE) 5-CHLORO-3-NITRO-2-PYRIDINE (2-HYDROXY-3-NITRO-5-CHLOROPYRIDINE) 5-chloro-3-nitropyridin-2(1H)-one 21427-61-2 C5H3N2O3Cl C5H3ClN2O3 Halopyridines Chloropyridines Heterocycle-Pyridine series Chloropyridines Halopyridines Bases & Related Reagents Nucleotides blocks NitroCompounds Pyridines Pyridine