5-Chloro-2-hydroxy-3-nitropyridine
- CAS No.
- 21427-61-2
- Chemical Name:
- 5-Chloro-2-hydroxy-3-nitropyridine
- Synonyms
- 5-Chlo;NSC 64258;5-Chloro-3-nitro-2-pyridone;5-CHLORO-3-NITRO-2-PYRIDINOL;5-CHLORO-3-NITROPYRIDIN-2-OL;oro-2-hydroxy-3-nitropyridine;5-chloro-3-nitro-1H-pyridin-2-one;5-Chloro-3-nitro-2(1H)-pyridinone;5-chloro-3-nitropyridin-2(1H)-one;5-Chloro-3-nitropyridin-2-ol, 95+%
- CBNumber:
- CB2479170
- Molecular Formula:
- C5H3ClN2O3
- Molecular Weight:
- 174.54
- MDL Number:
- MFCD00114884
- MOL File:
- 21427-61-2.mol
- MSDS File:
- SDS
| Melting point | 232-236 °C |
|---|---|
| Boiling point | 284.1±40.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Dimethylformamide |
| form | powder to crystal |
| pka | 6.31±0.10(Predicted) |
| color | Light yellow to Yellow to Green |
| BRN | 383852 |
| CAS DataBase Reference | 21427-61-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-39-36-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
5-Chloro-2-hydroxy-3-nitropyridine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 679747 | 5-Chloro-2-hydroxy-3-nitropyridine 97% | 21427-61-2 | 1g | $124 | 2023-01-07 | Buy |
| TCI Chemical | C1972 | 5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T) | 21427-61-2 | 5g | $136 | 2025-07-31 | Buy |
| TCI Chemical | C1972 | 5-Chloro-2-hydroxy-3-nitropyridine >98.0%(T) | 21427-61-2 | 25g | $404 | 2025-07-31 | Buy |
| TRC | C366650 | 5-Chloro-2-hydroxy-3-nitropyridine | 21427-61-2 | 5g | $90 | 2021-12-16 | Buy |
| Usbiological | C5010-30 | 5-Chloro-2-hydroxy-3-nitropyridine | 21427-61-2 | 10g | $425 | 2021-12-16 | Buy |
5-Chloro-2-hydroxy-3-nitropyridine Chemical Properties,Uses,Production
Chemical Properties
White to light brown solid
Uses
5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis.
Synthesis
1072-98-6
21427-61-2
Preparation of Example A2 5-chloro-2-hydroxy-3-nitropyridine (STR9): 321 g of 2-amino-5-chloropyridine was slowly added dropwise to 1.25 L of concentrated sulfuric acid with continuous stirring until the raw material was completely dissolved. Subsequently, 172.5 g of sodium nitrite (dissolved in 240 mL of water) was slowly added at 40°C to 45°C and the reaction mixture continued to be stirred for 15 minutes. Next, 125 mL of pure nitric acid was slowly added dropwise over 40 minutes at 50°C. The reaction mixture was maintained at 55°C for 1 hour and then the reaction was quenched by pouring into 5 kg of ice water. The yellow precipitated product was collected by filtration, washed thoroughly with deionized water and dried at 60°C to afford 351 g of 5-chloro-2-hydroxy-3-nitropyridine in 80.5% of the theoretical yield and a melting point of 229°C to 231°C.
References
[1] Patent: US5274100, 1993, A
[2] Yakugaku Zasshi, 1952, vol. 72, p. 431
[3] Chem.Abstr., 1953, p. 6404
5-Chloro-2-hydroxy-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12371 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20191 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49959 | 58 |
View Lastest Price from 5-Chloro-2-hydroxy-3-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-08-08 | 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
|
US $50.00 / kg | 1kg | 99% | 20tons | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-07-25 | 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-06-24 | 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
- US $50.00 / kg
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Chloro-2-hydroxy-3-nitropyridine
21427-61-2
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
