4-(Methylamino)benzoic acid
- CAS No.
- 10541-83-0
- Chemical Name:
- 4-(Methylamino)benzoic acid
- Synonyms
- 4-(N-METHYLAMINO)BENZOIC ACID;4-MABA;NSC 102506;4-(methylamino)benzoate;Benzoic acid Impurity 4;Balofloxacin Impurity 2;Benzoic acid Impurity 11;4-(methylamino)-benzoicaci;PARA-METHYLAMINOBENZOICACID;4-(METHYLAMINO)BENZOIC ACID
- CBNumber:
- CB2484941
- Molecular Formula:
- C8H9NO2
- Molecular Weight:
- 151.16
- MDL Number:
- MFCD00002535
- MOL File:
- 10541-83-0.mol
- MSDS File:
- SDS
| Melting point | 160-162 °C (lit.) |
|---|---|
| Boiling point | 273.17°C (rough estimate) |
| Density | 1.2023 (rough estimate) |
| refractive index | 1.5810 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Slightly soluble. Soluble in alcohol. |
| pka | 5.04(at 25℃) |
| form | Solid |
| color | Off-White to Dark Beige |
| BRN | 2082805 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C8H9NO2/c1-9-7-4-2-6(3-5-7)8(10)11/h2-5,9H,1H3,(H,10,11) |
| InChIKey | ZVIDMSBTYRSMAR-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(NC)C=C1 |
| CAS DataBase Reference | 10541-83-0(CAS DataBase Reference) |
| FDA UNII | ARU98Z0OZY |
| NIST Chemistry Reference | Benzoic acid, 4-(methylamino)-(10541-83-0) |
| EPA Substance Registry System | Benzoic acid, 4-(methylamino)- (10541-83-0) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi,N | |||||||||
| Risk Statements | 22-43-36/37/38-51/53-40 | |||||||||
| Safety Statements | 36/37-37/39-26-61 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2922290090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Skin Sens. 1 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-(Methylamino)benzoic acid price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 119695 | 4-(Methylamino)benzoic acid 97% | 10541-83-0 | 10g | $88.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 119695 | 4-(Methylamino)benzoic acid 97% | 10541-83-0 | 50g | $350 | 2026-04-30 | Buy |
| TCI Chemical | M0267 | 4-(Methylamino)benzoic Acid >98.0%(HPLC)(T) | 10541-83-0 | 5g | $54 | 2026-04-30 | Buy |
| TCI Chemical | M0267 | 4-(Methylamino)benzoic Acid >98.0%(HPLC)(T) | 10541-83-0 | 25g | $213 | 2026-04-30 | Buy |
| TRC | TRC-M285665-5G | 4-(Methylamino)benzoic Acid | 10541-83-0 | 5g | $70 | 2026-06-03 | Buy |
4-(Methylamino)benzoic acid Chemical Properties,Uses,Production
Description
4-(Methylamino) benzoic acid is an important intermediate for production of pharmaceutical products, dyes, flavors and preservatives.
Chemical Properties
white to beige powder
Uses
4-(Methylamino)benzoic acid important for the preparation of other pharmaceutical products, dyes, flavors, and preservatives. .For the preparation of medicines and other fine chemicals.
Definition
ChEBI: N-Methyl-4-aminobenzoate is an aminobenzoic acid.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
A mixture of 4-bromobenzoic acid (10 mmol), aqueous methylamine (5.4 mL, 5 equiv.), copper powder (0.032 g, 5 mol%), and a stirring bar was sealed in a dry reaction flask in a 30 ml threaded tube. The reaction mixture was stirred electromagnetically in an oil bath at 100C to dissolve the copper powder. After completion of the reaction (12 h), the reaction mixture was cooled to room temperature. The aromatic amine was extracted by adding ethyl acetate (20 ml) and the organic layer was separated. The aqueous layer was extracted with ethyl acetate (3 10 mL) and all the organic layers were combined and dried with anhydrous sodium sulfate. The precipitate in the reaction mixture was removed by filtration and the resulting filtrate was concentrated under reduced pressure to remove the solvent, and finally the resulting residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate) to obtain the target product molecule, 4-methylaminobenzoic acid.
References
https://www.alfa.com/en/catalog/A12426/
4-(Methylamino)benzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yancheng Shunde Chemical Technology Co., Ltd. | 13661532809; 13813431578 | tianleyu@163.com | China | 80 | 58 |
| FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd | 25-8690-7345 18651693585 | zfx@farmasino.com | China | 136 | 58 |
| NanJing Vtrying Pharmatech Co.,Ltd | 173 1418 6806; 17314186806 | Vtrying_sale@163.com | China | 303 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 4-(Methylamino)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-03 | 4-(Methylamino)benzoic acid
10541-83-0
|
1kg | 0.98 | 1000 | Henan Boweixin Biotechnology Co., Ltd. | ||
 |
2026-06-30 | 4-(Methylamino)benzoic acid
10541-83-0
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 4-(Methylamino)benzoic acid
10541-83-0
|
$1.00 | 1kg | 95%-99% | Career Henan Chemical Co |
-
- 4-(Methylamino)benzoic acid
10541-83-0
- $0.00
- 0.98
- Henan Boweixin Biotechnology Co., Ltd.
-
- 4-(Methylamino)benzoic acid
10541-83-0
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-(Methylamino)benzoic acid
10541-83-0
- $1.00
- 95%-99%
- Career Henan Chemical Co
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