ChemicalBook >> CAS DataBase List >>4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid

CAS No.
5623-18-7
Chemical Name:
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid
Synonyms
Metfol-B;NSC 408937;Methotrexate-EP-Imp-D;N10-Methyl Pteroic Acid;Methotrexate EP Impurity D;Methotrexate Impurity 4(EP-D);Methotrexate Impurity 4(Methotrexate EP Impurity D);Methotrexate EP Impurity D(Amethopterin EP Impurity D);4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino}benzoic acid;p-[(2-Amino-4-hydroxy-6-pteridinyl)methyl(methyl)amino]benzoic acid
CBNumber:
CB02262484
Molecular Formula:
C15H14N6O3
Molecular Weight:
326.31
MDL Number:
MOL File:
5623-18-7.mol
MSDS File:
SDS
Last updated:2026-01-13 11:13:15
Product description Number Pack Size Price
Methotrexate impurity D European Pharmacopoeia (EP) Reference Standard M1000008 15 mg $254
Methotrexate impurity D European Pharmacopoeia (EP) Reference Standard M1000008 m1000008 $220
N10-Methyl pteroic acid FM25554 50mg $900
N10-Methyl pteroic acid FM25554 25mg $900
N10-Methyl pteroic acid FM25554 100mg $1168
More product size

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Properties

Melting point >245°C (dec.)
Boiling point 583.7±60.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Aqueous Base (Slightly), DMSO (Very Slightly, Heated), Methanol (Very Slightly)
pka 4.74±0.10(Predicted)
color Orange to Red
Major Application pharmaceutical (small molecule)
InChI 1S/C15H14N6O3/c1-21(10-4-2-8(3-5-10)14(23)24)7-9-6-17-12-11(18-9)13(22)20-15(16)19-12/h2-6H,7H2,1H3,(H,23,24)(H3,16,17,19,20,22)
InChIKey QHNLFEQJGRZKTK-UHFFFAOYSA-N
SMILES [nH]1c2nc(n[c](c2nc(c1)CN(C)c3ccc(cc3)C(=O)O)=O)N
FDA UNII 9RHB9JD89E
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M1000008 Methotrexate impurity D European Pharmacopoeia (EP) Reference Standard 5623-18-7 15 mg $254 2026-04-30 Buy
Sigma-Aldrich M1000008 Methotrexate impurity D European Pharmacopoeia (EP) Reference Standard 5623-18-7 m1000008 $220 2024-03-01 Buy
Biosynth FM25554 N10-Methyl pteroic acid 5623-18-7 50mg $900 2026-06-04 Buy
Biosynth FM25554 N10-Methyl pteroic acid 5623-18-7 25mg $900 2026-06-04 Buy
Biosynth FM25554 N10-Methyl pteroic acid 5623-18-7 100mg $1168 2026-06-04 Buy
Product number Packaging Price Buy
M1000008 15 mg $254 Buy
M1000008 m1000008 $220 Buy
FM25554 50mg $900 Buy
FM25554 25mg $900 Buy
FM25554 100mg $1168 Buy

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Chemical Properties,Uses,Production

Chemical Properties

Dark Orange Solid

Uses

N10-Methyl Pteroic Acid (Methotrexate EP Impurity D) is a Methotrexate (M260675) impurity D.

Uses

Methotrexate (M260675) impurity D.

150-13-0
5623-18-7
Synthesis of 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid from 4-Aminobenzoic acid

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Preparation Products And Raw materials

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14320 58
Finetech Industry Limited
+86-27-8746-5837 +86-18627785180 info@finetechnology-ind.com China 9539 58
BOC Sciences
16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
sgtlifesciences pvt ltd
+91-8790379245 dj@sgtlifesciences.com China 12351 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131885 58
QUALITY CONTROL SOLUTIONS LTD.
+86-0755-66853366 +8613670046396 export03@qcsrm.com China 24318 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6748 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 5000 50
p-[(2-Amino-4-hydroxy-6-pteridinyl)methyl(methyl)amino]benzoic acid N10-Methyl Pteroic Acid 4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoic Acid Metfol-B NSC 408937 4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino}benzoic acid Methotrexate EP Impurity D Methotrexate Impurity 4(EP-D) Methotrexate EP Impurity D/N10-Methylpteroic acid/4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzoic acid Methotrexate EP Impurity D(Amethopterin EP Impurity D) Methotrexate-EP-Imp-D 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzoic acid Benzoic acid, 4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]- Methotrexate Impurity 4(Methotrexate EP Impurity D) 4-(((2-Amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)(methyl)amino)benzoic acid (Methotrexate Impurity) 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid 5623-18-7 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals