4-acetamidobenzoic acid
- CAS No.
- 556-08-1
- Chemical Name:
- 4-acetamidobenzoic acid
- Synonyms
- P-ACETAMIDOBENZOIC ACID;4-ACETAMIDOBENZOIC ACID;Acedoben;p-acetamidobenzoic;PAAB;P-ACETAMINOBENZOIC ACID;4-ACETAMIDOBENZOIC ACID FOR SYNTHESIS;p-Acetylamino benzoic acido benzoic acid;LR-64;PAABA
- CBNumber:
- CB9465840
- Molecular Formula:
- C9H9NO3
- Molecular Weight:
- 179.17
- MDL Number:
- MFCD00002534
- MOL File:
- 556-08-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 259-262 °C (dec.)(lit.) |
|---|---|
| Boiling point | 311.69°C (rough estimate) |
| Density | 1.2822 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | pK1: 4.28 (25°C) |
| form | Powder |
| color | Off-white to slightly beige |
| Water Solubility | <0.1 g/100 mL at 21 ºC |
| BRN | 390602 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Major Application | peptide synthesis |
| InChI | 1S/C9H9NO3/c1-6(11)10-8-4-2-7(3-5-8)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13) |
| InChIKey | QCXJEYYXVJIFCE-UHFFFAOYSA-N |
| SMILES | CC(=O)Nc1ccc(cc1)C(O)=O |
| CAS DataBase Reference | 556-08-1(CAS DataBase Reference) |
| FDA UNII | 04Z20NMK31 |
| NIST Chemistry Reference | N-(4-Carboxyphenyl)acetic acid amide(556-08-1) |
| EPA Substance Registry System | Benzoic acid, 4-(acetylamino)- (556-08-1) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29242995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-acetamidobenzoic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 133337 | 4-Acetamidobenzoic acid 98% | 556-08-1 | 25g | $43.3 | 2026-04-30 | Buy |
| TCI Chemical | A0013 | 4-Acetamidobenzoic Acid >99.0%(T) | 556-08-1 | 25g | $27 | 2026-04-30 | Buy |
| TCI Chemical | A0013 | 4-Acetamidobenzoic Acid >99.0%(T) | 556-08-1 | 500g | $156 | 2026-04-30 | Buy |
| Usbiological | 001043 | Acedoben | 556-08-1 | 5g | $312 | 2026-06-03 | Buy |
| Biosynth | FA00388 | 4-Acetamidobenzoic acid | 556-08-1 | 0.5kg | $190.47 | 2026-06-04 | Buy |
4-acetamidobenzoic acid Chemical Properties, Uses, Production
Description
4-Acetamidobenzoic acid (PAcBA) is a naturally occurring acetylated metabolite of 4-aminobenzoic acid and is a component of the antiviral and immunostimulatory drug inosine pranobex (Inosiplex; Isoprinosine; Methisoprinol).
Chemical Properties
white or off-white powder or crystals
Originator
4-Acetamidobenzoic acid ,ARIAC
Uses
immune stimulant (component)
Uses
Acedoben is the acetylated derivative of p-aminobenzoic acid (PABA). Acedoben is a metabolite of the anesthetic Benzocaine (B202970).
Definition
ChEBI: 4-acetamidobenzoic acid is a amidobenzoic acid that consists of benzoic acid bearing an acetamido substituent at position 4. It is functionally related to a 4-aminobenzoic acid. It is a conjugate acid of a 4-acetamidobenzoate.
Manufacturing Process
Into a 2 L, 3-necked flask set in a tub and equipped with a stirrer, an air condenser (drying tube), thermometer, was placed 860 ml of water, 43.0 g of MgSO4 and 43.0 g of sodium acetate and heated on water bath. Into heated solution to 70°C stirring 43.0 g of N-p-tolylacetamide were added. Then 136.0 g of KMnO4 by small portions were added at 75°-80°C. The reaction mixture allow to stand for 6 h and stirring was continue till the solution became colorless. Hot solution was filtered and filtrate treated hydrochloric acid to slightly acidic pH. After that 44.0 g (85%) of p-acetoaminobenzoic acid was obtained as white precipitate, melting point 250°C.
Therapeutic Function
Antiviral
General Description
Needles or off-white powder.
Air & Water Reactions
Water insoluble.
Reactivity Profile
Simultaneously an amide and a carboxylic acid.
Fire Hazard
Flash point data for p-Acetylamino benzoic acid are not available; however, p-Acetylamino benzoic acid is probably combustible.
reaction suitability
reaction type: solution phase peptide synthesis
References
[1] Synthetic Communications, 2008, vol. 38, # 7, p. 1028 - 1035
[2] Applied Catalysis A: General, 2013, vol. 456, p. 118 - 125
[3] Green Chemistry, 2012, vol. 14, # 3, p. 847 - 854
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 9, p. 1274 - 1281
[5] Synthetic Communications, 2008, vol. 38, # 17, p. 2929 - 2940
4-acetamidobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Sunlight Pharmaceutical Co., Ltd | 519-83131668 15995063688 | info@sunlightchem.com | China | 100 | 69 |
| Changzhou Joyous Chemical Co., Ltd. | 0519-85607258 | sales@joyouschem.com | China | 292 | 60 |
| Wuhan hongde yuexin pharmaceutical technology co. LTD | 027-83855395 13995685043 | wuhanfudechem23@163.com | China | 997 | 58 |
| Ningbo Fuhe Chemical Co., Ltd. | 0574-1806900 18069001216 | nbfjj@126.com | China | 99 | 58 |
| Shaanxi Delavite Biotechnology Co., Ltd. | 15780788769 18292741956 | 409357995@qq.com | China | 498 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd. | 0519-85195575 15861192208;15861192208;13685253038 | 850305@sunkechem.com | China | 72 | 69 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 4-acetamidobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-19 | 4-acetamidobenzoic acid
556-08-1
|
1KG | 98% | 1000 KG | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-08-08 | Acedoben
556-08-1
|
$29.00 | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-08 | Acedoben
556-08-1
|
$29.00 | 99.91% | 10g | TargetMol Chemicals Inc. |
-
- 4-acetamidobenzoic acid
556-08-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Acedoben
556-08-1
- $29.00
- 99.91%
- TargetMol Chemicals Inc.
-
- Acedoben
556-08-1
- $29.00
- 99.91%
- TargetMol Chemicals Inc.
