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4-Bromo-2,6-difluorobenzyl alcohol

4-Bromo-2,6-difluorobenzyl alcohol structure

CAS No.: 162744-59-4

Chemical Name:: 4-Bromo-2,6-difluorobenzyl alcohol

Synonyms: (4-BROMO-2,6-DIFLUOROPHENYL)METHANOL;CAS:162744-59-4;RARECHEM AL BD 1306;4-bromo-2,6-difluorobenzyl;2,6-DIFLUORO-4-BROMOBENZYLALCOHOL;4-Bromo-2,6-difluorobenzyl alcohol;4-bromo-2,6-difluoro-benzenemethanol;Benzenemethanol, 4-bromo-2,6-difluoro-

CBNumber:: CB2493088

Molecular Formula:: C7H5BrF2O

Molecular Weight:: 223.01

MDL Number:: MFCD03094461

MOL File:: 162744-59-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:19

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4-Bromo-2,6-difluorobenzyl alcohol Properties

Melting point	76-81 °C (lit.)
Boiling point	250℃
Density	1.744
Flash point	105℃
storage temp.	Sealed in dry,Room Temperature
form	Solid
pka	13.21±0.10(Predicted)
color	White to Light yellow
InChI	1S/C7H5BrF2O/c8-4-1-6(9)5(3-11)7(10)2-4/h1-2,11H,3H2
InChIKey	LSRHFWSNUFIKER-UHFFFAOYSA-N
SMILES	OCc1c(F)cc(Br)cc1F
CAS DataBase Reference	162744-59-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

2906290090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-Bromo-2,6-difluorobenzyl alcohol price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	533033	4-Bromo-2,6-difluorobenzyl alcohol 98%	162744-59-4	5g	$86.1	2026-04-30	Buy
TCI Chemical	B5090	4-Bromo-2,6-difluorobenzyl Alcohol >98.0%(GC)	162744-59-4	1g	$55	2026-04-30	Buy
TCI Chemical	B5090	4-Bromo-2,6-difluorobenzyl Alcohol >98.0%(GC)	162744-59-4	5g	$165	2026-04-30	Buy
AstaTech	56967	4-BROMO-2,6-DIFLUOROBENZYLALCOHOL 97%	162744-59-4	1G	$30	2026-04-30	Buy
AstaTech	56967	4-BROMO-2,6-DIFLUOROBENZYLALCOHOL 97%	162744-59-4	5G	$45	2026-04-30	Buy

Product number	Packaging	Price	Buy
533033	5g	$86.1	Buy
B5090	1g	$55	Buy
B5090	5g	$165	Buy
56967	1G	$30	Buy
56967	5G	$45	Buy

4-Bromo-2,6-difluorobenzyl alcohol Chemical Properties, Uses, Production

Uses

4-Bromo-2,6-difluorobenzyl alcohol is an organic intermediate. It has been reported that 4-bromo-2,6-difluorobenzyl alcohol can be used to prepare RET inhibitors.

Application

4-Bromo-2,6-difluorobenzyl alcohol can be used to prepare RET inhibitors.

Preparation

4-Bromo-2,6-difluorobenzyl alcohol can be obtained by reducing the carboxyl group from 4-bromo-3,5-difluorobenzoic acid.

Synthesis

183065-68-1

162744-59-4

General procedure for the synthesis of 4-bromo-2,6-difluorobenzenemethanol from 2,6-difluoro-4-bromobenzoic acid: to a solution of 2,6-difluoro-4-bromobenzoic acid (5 g, 21.10 mmol) in tetrahydrofuran (THF, 100 mL) was slowly added borane (BH3). Dimethyl sulfide (DMS, 20.03 mL, 211 mmol) was added dropwise at room temperature. The reaction mixture was stirred at 60 °C for 16 hours. After confirming complete consumption of the feedstock by liquid chromatography-mass spectrometry (LCMS) analysis, the reaction was quenched with methanol (MeOH). The solvent was evaporated under reduced pressure to afford 4-bromo-2,6-difluorobenzenemethanol as a white solid (4.5 g, 20.02 mmol, 95.2% yield), which could be used in subsequent reactions without further purification. Electrospray liquid chromatography-mass spectrometry (ES-LCMS) analysis showed m/z 222.1 ([M+H]+).

References

[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0371; 0372
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 81; 82
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 10, p. 3258 - 3262

4-Bromo-2,6-difluorobenzyl alcohol synthesis

Synthesis of 4-Bromo-2,6-difluorobenzyl alcohol from 4-Bromo-2,6-difluorobenzaldehyde

4-Bromo-2,6-difluorobenzyl alcohol Preparation Products And Raw materials

Raw materials

4-Bromo-2,6-difluorobenzaldehyde 4-Bromo-2,6-difluorobenzoic acid 1-Bromo-3,5-difluorobenzene Tetrahydrofuran Borane-methyl sulfide complex

Preparation Products

3,5-Difluoro-4-(hydroxymethyl)phenylboronic acid 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzenemethanol

4-Bromo-2,6-difluorobenzyl alcohol Suppliers

Global Suppliers ( 217)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64

View Latest Price from 4-Bromo-2,6-difluorobenzyl alcohol manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	(4-bromo-2,6-difluorophenyl)methanol 162744-59-4	20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.
2026-03-20	4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL 162744-59-4	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-02-02	4-BroMo-2,6-difluorobenzyl alcohol 162744-59-4	10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd

(4-bromo-2,6-difluorophenyl)methanol
162744-59-4
$0.00
99%
Qingdao RENAS Polymer Material Co., Ltd.

4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL
162744-59-4
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-BroMo-2,6-difluorobenzyl alcohol
162744-59-4
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

4-Bromo-2,6-difluorobenzyl alcohol Spectrum

4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL(162744-59-4)¹HNMR 4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL(162744-59-4)¹⁹FNMR

162744-59-4 (4-Bromo-2,6-difluorobenzyl alcohol) Related Search:

2-Bromoethanol Methyl 4-bromo-2,6-difluorobenzoate 4-Bromo-2,3,5,6-tetrafluorobenzoic acid 4-Bromo-2,6-difluorobenzyl alcohol 4-Bromo-2,3,5,6-tetrafluorobenzylalcohol

4-Bromo-2,6-difluorobenzoic acid 2,6-Difluorobenzyl alcohol RARECHEM AL BP 1306 tert-Butyl 4-bromo-2,6-difluorobenzoate 4-Bromo-2,3,6-trifluorobenzyl alcohol

tert-Butyl 4-bromo-2,3,5,6-tetrafluorobenzoate 6-Bromo-2,3-difluorobenzyl alcohol RARECHEM AL BI 1306 ethyl 4-bromo-2,3,5,6-tetrafluorobenzimidate RARECHEM AL BE 1308

RARECHEM AL BF 1308 RARECHEM AL BP 1308 RARECHEM AL BI 1308

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RARECHEM AL BD 1306 2,6-DIFLUORO-4-BROMOBENZYLALCOHOL 4-bromo-2,6-difluoro-benzenemethanol 4-bromo-2,6-difluorobenzyl Benzenemethanol, 4-bromo-2,6-difluoro- CAS:162744-59-4 (4-BROMO-2,6-DIFLUOROPHENYL)METHANOL 4-Bromo-2,6-difluorobenzyl alcohol 162744-59-4 161359-09-3 F2C6H2BrCH2OH Organic Building Blocks Oxygen Compounds Building Blocks Alcohols C7 to C8 Pharmaceutical intermediate Benzhydrols, Benzyl & Special Alcohols Alcohol Miscellaneous Alcohols C7 to C8 Oxygen Compounds