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1-Bromo-3,5-difluorobenzene

1-Bromo-3,5-difluorobenzene structure

CAS No.: 461-96-1

Chemical Name:: 1-Bromo-3,5-difluorobenzene

Synonyms: 3,5-DIFLUOROBROMOBENZENE;1-Brom-3,5-difluorbenzol;1,3-Difluoro-5-bromobenzene;DM1Impurity22;uorobromobenzene;5-difluorobenzene;1-Bromo-3,5-difluoro;3,5-difluoro-1-bromobenzene;1-BROMO-3,5-DIFLUOROBENZENE;1-Bromo-3,5-difulorobenzene

CBNumber:: CB3668317

Molecular Formula:: C6H3BrF2

Molecular Weight:: 192.99

MDL Number:: MFCD00010305

MOL File:: 461-96-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:00:03

Product description	Number	Pack Size	Price
1-Bromo-3,5-difluorobenzene 98%	290165	10g	$89.3
1-Bromo-3,5-difluorobenzene 98%	290165	100g	$228
1-Bromo-3,5-difluorobenzene >98.0%(GC)	B1764	25g	$60
1-Bromo-3,5-difluorobenzene >98.0%(GC)	B1764	250g	$241
1-Bromo-3,5-difluorobenzene, min. 99% min.99%	09-0055	25g	$88
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1-Bromo-3,5-difluorobenzene Properties

Melting point	-27 °C
Boiling point	140 °C (lit.)
Density	1.676 g/mL at 25 °C (lit.)
refractive index	n20/D 1.499(lit.)
Flash point	112 °F
storage temp.	Sealed in dry,2-8°C
solubility	0.238g/l
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	1.686
PH	6.6 (0.238g/l, H2O, 20℃)
Water Solubility	0.238 g/L (20 ºC)
BRN	1931520
InChI	1S/C6H3BrF2/c7-4-1-5(8)3-6(9)2-4/h1-3H
InChIKey	JHLKSIOJYMGSMB-UHFFFAOYSA-N
SMILES	Fc1cc(F)cc(Br)c1
CAS DataBase Reference	461-96-1(CAS DataBase Reference)
EWG's Food Scores	1-3
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07,GHS08,GHS09

Signal word

Warning

Hazard statements

H226-H302-H315-H317-H373-H410

Precautionary statements

P210-P273-P280-P301+P312-P303+P361+P353-P314

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,N,F,Xi

Risk Statements

10-22-38-43-48/22-50/53-36/37/38

Safety Statements

24-36/37-60-61-36-26-16

RIDADR

UN 1993 3/PG 3

WGK Germany

Hazard Note

Flammable

HazardClass

PackingGroup

III

HS Code

29039990

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Flam. Liq. 3
Skin Irrit. 2
Skin Sens. 1
STOT RE 2

REACH Registrations

Active

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
2		0

1-Bromo-3,5-difluorobenzene price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	290165	1-Bromo-3,5-difluorobenzene 98%	461-96-1	10g	$89.3	2026-04-30	Buy
Sigma-Aldrich	290165	1-Bromo-3,5-difluorobenzene 98%	461-96-1	100g	$228	2026-04-30	Buy
TCI Chemical	B1764	1-Bromo-3,5-difluorobenzene >98.0%(GC)	461-96-1	25g	$60	2026-04-30	Buy
TCI Chemical	B1764	1-Bromo-3,5-difluorobenzene >98.0%(GC)	461-96-1	250g	$241	2026-04-30	Buy
Strem Chemicals	09-0055	1-Bromo-3,5-difluorobenzene, min. 99% min.99%	461-96-1	25g	$88	2026-04-30	Buy

Product number	Packaging	Price	Buy
290165	10g	$89.3	Buy
290165	100g	$228	Buy
B1764	25g	$60	Buy
B1764	250g	$241	Buy
09-0055	25g	$88	Buy

1-Bromo-3,5-difluorobenzene Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

1-Bromo-3,5-difluorobenzene was used in the synthesis of 4-bromo-2,6-difluorobenzoic acid.

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008

Synthesis

6303-21-5

2-BROMO-4,6-DIFLUOROANILINE HYDROBROMIDE

101471-20-9

461-96-1

General procedure: A diazonium salt solution was prepared by dissolving 1 mole of 2-bromo-4,6-difluoroaniline hydrobromide in aqueous HCl with 1.1-1.10 moles of NaNO2 at 0°C to 5°C. The solution was then slowly warmed to 15°C, during which time the release of nitrogen was observed. To this solution, 1.5 moles of hypophosphorous acid was added at a temperature below 5°C, followed by a slow warming to 15°C, during which the release of nitrogen was observed. The reaction mixture is stirred for 1 hour, decanted and extracted with a suitable organic solvent to give 1-bromo-3,5-difluorobenzene in 75% molar yield. The target product with purity higher than 99% was obtained by distillation. This method is also applicable to the synthesis of other 1-bromo-3,5-dihalobenzenes.

References

[1] Patent: US5157169, 1992, A

1-Bromo-3,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Hydrochloric acid Bromine Hypophosphorous acid 2-BROMO-4,6-DIFLUOROANILINE HYDROBROMIDE Sodium nitrite

Preparation Products

2,6-Difluoro-4-hydroxybenzonitrile 3,5-DIFLUORO-BENZAMIDINE HYDROCHLORIDE 3,5-Difluorobenzoic acid 1-ETHYNYL-3 5-DIFLUOROBENZENE 97 4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL

4-Bromo-2,6-difluoroiodobenzene 6-BROMO-4-FLUORO-1H-INDAZOLE (3 5-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL& 9,9'-(5-bromo-1,3-phenylene)bis(9H-carbazole)

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1-Bromo-3,5-difluorobenzene Suppliers

Global( 567)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Qi-Chem Co., Ltd.	+86-041188165951	cristiano.zhang@qi-chem.com	China	133	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5229	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60

Supplier	Advantage
Qi-Chem Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Hi-Tech Chemistry Corp	58
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from 1-Bromo-3,5-difluorobenzene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	1-Bromo-3,5-difluorobenzene 461-96-1	$20.60	1KG	99%	5000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	1-Bromo-3,5-difluorobenzene 461-96-1		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	1-Bromo-3,5-difluorobenzene 461-96-1		1KG	99.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

1-Bromo-3,5-difluorobenzene
461-96-1
$20.60
99%
Hebei Chuanghai Biotechnology Co,.LTD

1-Bromo-3,5-difluorobenzene
461-96-1
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-Bromo-3,5-difluorobenzene
461-96-1
99.0%
Shaanxi Dideu New Materials Co. Ltd

1-Bromo-3,5-difluorobenzene Spectrum

1-Bromo-3,5-difluorobenzene(461-96-1)MS 1-Bromo-3,5-difluorobenzene(461-96-1)¹HNMR 1-Bromo-3,5-difluorobenzene(461-96-1)¹³CNMR 1-Bromo-3,5-difluorobenzene(461-96-1)IR1

461-96-1(1-Bromo-3,5-difluorobenzene)Related Search:

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1-Bromo-3,5-difluorobenzene,99% 1-BROMO-3,5-DIFLUOROBENZENE 1-Bromo-3,5-difluorobenzene,98% [3,5-Difluorobromobenzene] 3,5-difluoro-1-bromobenzene 1-Bromo-3,5-difluorobenzene 98% 1-Bromo-3,5-difluorobenzene98% 3,5-DIFLUOROBROMOBENZENE A.K.A.1-BROMO-3,5-DIFLUOR 3,5-DIFLUORO BROMO BENZENE 461-96-1 1-BroMo-35-difluorobenzene/35-Difluorochlorobenzene 3,5-DifluorobroMobenzene, 97+% 3, 5 - two fluorine broMobenzene 1-Bromo-3,5-difulorobenzene 1-Bromo-3,5-difluoro 3,5-Difluorobromobenzene 98% 5-difluorobenzene 1-BroMo-3,5-difluorobenzene, 99% 10ML 1-Bromo-3,5-difluorobenzene > uorobromobenzene Benzene, 1-bromo-3,5-difluoro- 1-Bromo-3,5-difluorobenzene ISO 9001：2015 REACH DM1Impurity22 1-Bromo-3,5-difluorobenzene, 98%min 1,3-Difluoro-5-bromobenzene 1-Brom-3,5-difluorbenzol 3,5-DIFLUOROBROMOBENZENE 461-96-1 C6H3BrF2 HALIDE Organic Building Blocks Halogenated Hydrocarbons Aryl Building Blocks C6 Fluorine series Fluorobenzene Miscellaneous Aryl Halogenated Hydrocarbons Aromatic Hydrocarbons (substituted) & Derivatives bc0001 C6